| Full name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | Alias Symbol: DKFZP586G1517|FLJ21145 | ||
| Type: protein-coding gene | Cytoband: 6q25.1 | ||
| Entrez ID: 25902 | HGNC ID: HGNC:21055 | Ensembl Gene: ENSG00000120254 | OMIM ID: 611427 |
| Drug and gene relationship at DGIdb | |||
Expression of MTHFD1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTHFD1L | 25902 | 1561125_at | 0.1597 | 0.6499 | |
| GSE26886 | MTHFD1L | 25902 | 1561125_at | 0.1223 | 0.3304 | |
| GSE53622 | MTHFD1L | 25902 | 59727 | 2.1195 | 0.0000 | |
| GSE53624 | MTHFD1L | 25902 | 59727 | 2.4101 | 0.0000 | |
| GSE63941 | MTHFD1L | 25902 | 1561125_at | 0.1504 | 0.4820 | |
| GSE77861 | MTHFD1L | 25902 | 1561125_at | -0.1849 | 0.0314 | |
| GSE97050 | MTHFD1L | 25902 | A_32_P135243 | 0.7821 | 0.2612 | |
| SRP007169 | MTHFD1L | 25902 | RNAseq | 3.6242 | 0.0000 | |
| SRP008496 | MTHFD1L | 25902 | RNAseq | 2.7292 | 0.0000 | |
| SRP064894 | MTHFD1L | 25902 | RNAseq | 2.0373 | 0.0000 | |
| SRP133303 | MTHFD1L | 25902 | RNAseq | 2.0622 | 0.0000 | |
| SRP159526 | MTHFD1L | 25902 | RNAseq | 1.6097 | 0.0000 | |
| SRP193095 | MTHFD1L | 25902 | RNAseq | 1.7067 | 0.0000 | |
| SRP219564 | MTHFD1L | 25902 | RNAseq | 1.3345 | 0.0095 | |
| TCGA | MTHFD1L | 25902 | RNAseq | 0.5525 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by MTHFD1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTHFD1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTHFD1L | 25902 | 1 | 4 | 25 | |
| GSE20123 | MTHFD1L | 25902 | 1 | 3 | 26 | |
| GSE43470 | MTHFD1L | 25902 | 4 | 0 | 39 | |
| GSE46452 | MTHFD1L | 25902 | 3 | 10 | 46 | |
| GSE47630 | MTHFD1L | 25902 | 9 | 4 | 27 | |
| GSE54993 | MTHFD1L | 25902 | 3 | 2 | 65 | |
| GSE54994 | MTHFD1L | 25902 | 8 | 8 | 37 | |
| GSE60625 | MTHFD1L | 25902 | 0 | 1 | 10 | |
| GSE74703 | MTHFD1L | 25902 | 4 | 0 | 32 | |
| GSE74704 | MTHFD1L | 25902 | 0 | 1 | 19 | |
| TCGA | MTHFD1L | 25902 | 12 | 20 | 64 |
Total number of gains: 45; Total number of losses: 53; Total Number of normals: 390.
Somatic mutations of MTHFD1L:
Generating mutation plots.
Highly correlated genes for MTHFD1L:
Showing top 20/372 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTHFD1L | FAM89A | 0.828658 | 3 | 0 | 3 |
| MTHFD1L | CENPW | 0.789967 | 3 | 0 | 3 |
| MTHFD1L | ZDHHC16 | 0.78737 | 3 | 0 | 3 |
| MTHFD1L | MAD2L2 | 0.786839 | 3 | 0 | 3 |
| MTHFD1L | ATP6V1C1 | 0.785371 | 3 | 0 | 3 |
| MTHFD1L | CCNA2 | 0.778953 | 3 | 0 | 3 |
| MTHFD1L | APOC1 | 0.773372 | 3 | 0 | 3 |
| MTHFD1L | LRRC42 | 0.772993 | 3 | 0 | 3 |
| MTHFD1L | E2F4 | 0.772086 | 3 | 0 | 3 |
| MTHFD1L | EBNA1BP2 | 0.768372 | 3 | 0 | 3 |
| MTHFD1L | PPIL1 | 0.768273 | 3 | 0 | 3 |
| MTHFD1L | LRRC8C | 0.76562 | 3 | 0 | 3 |
| MTHFD1L | LSM5 | 0.76531 | 3 | 0 | 3 |
| MTHFD1L | GNL2 | 0.763528 | 3 | 0 | 3 |
| MTHFD1L | UCK2 | 0.76299 | 3 | 0 | 3 |
| MTHFD1L | NCLN | 0.76271 | 3 | 0 | 3 |
| MTHFD1L | MRPL47 | 0.761795 | 3 | 0 | 3 |
| MTHFD1L | GRAPL | 0.758454 | 3 | 0 | 3 |
| MTHFD1L | PSMB2 | 0.755045 | 4 | 0 | 4 |
| MTHFD1L | ORC1 | 0.747667 | 3 | 0 | 3 |
For details and further investigation, click here
