| Full name: CDC like kinase 3 | Alias Symbol: clk3 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 1198 | HGNC ID: HGNC:2071 | Ensembl Gene: ENSG00000179335 | OMIM ID: 602990 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CLK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLK3 | 1198 | 202140_s_at | -0.4126 | 0.2312 | |
| GSE20347 | CLK3 | 1198 | 202140_s_at | -0.1838 | 0.1202 | |
| GSE23400 | CLK3 | 1198 | 202140_s_at | -0.2377 | 0.0000 | |
| GSE26886 | CLK3 | 1198 | 202140_s_at | -0.4370 | 0.0207 | |
| GSE29001 | CLK3 | 1198 | 202140_s_at | -0.5153 | 0.0714 | |
| GSE38129 | CLK3 | 1198 | 202140_s_at | -0.2303 | 0.0162 | |
| GSE45670 | CLK3 | 1198 | 202140_s_at | -0.0851 | 0.6124 | |
| GSE63941 | CLK3 | 1198 | 202140_s_at | 0.5558 | 0.1990 | |
| GSE77861 | CLK3 | 1198 | 202140_s_at | -0.1195 | 0.4597 | |
| GSE97050 | CLK3 | 1198 | A_32_P20691 | -0.2832 | 0.2764 | |
| SRP007169 | CLK3 | 1198 | RNAseq | -1.0242 | 0.0153 | |
| SRP008496 | CLK3 | 1198 | RNAseq | -1.0621 | 0.0010 | |
| SRP064894 | CLK3 | 1198 | RNAseq | -0.3377 | 0.0047 | |
| SRP133303 | CLK3 | 1198 | RNAseq | -0.2924 | 0.0380 | |
| SRP159526 | CLK3 | 1198 | RNAseq | -0.3597 | 0.0319 | |
| SRP193095 | CLK3 | 1198 | RNAseq | -0.0991 | 0.4305 | |
| SRP219564 | CLK3 | 1198 | RNAseq | -0.3939 | 0.2801 | |
| TCGA | CLK3 | 1198 | RNAseq | -0.1009 | 0.0412 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CLK3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CLK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLK3 | 1198 | 8 | 1 | 21 | |
| GSE20123 | CLK3 | 1198 | 8 | 1 | 21 | |
| GSE43470 | CLK3 | 1198 | 4 | 6 | 33 | |
| GSE46452 | CLK3 | 1198 | 3 | 7 | 49 | |
| GSE47630 | CLK3 | 1198 | 8 | 10 | 22 | |
| GSE54993 | CLK3 | 1198 | 5 | 6 | 59 | |
| GSE54994 | CLK3 | 1198 | 5 | 7 | 41 | |
| GSE60625 | CLK3 | 1198 | 4 | 0 | 7 | |
| GSE74703 | CLK3 | 1198 | 4 | 3 | 29 | |
| GSE74704 | CLK3 | 1198 | 4 | 1 | 15 | |
| TCGA | CLK3 | 1198 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of CLK3:
Generating mutation plots.
Highly correlated genes for CLK3:
Showing top 20/317 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLK3 | PKNOX2 | 0.76096 | 3 | 0 | 3 |
| CLK3 | ZNF608 | 0.758665 | 3 | 0 | 3 |
| CLK3 | RILP | 0.751665 | 3 | 0 | 3 |
| CLK3 | APEH | 0.750283 | 3 | 0 | 3 |
| CLK3 | MAPK12 | 0.742801 | 3 | 0 | 3 |
| CLK3 | ARPC1A | 0.742361 | 3 | 0 | 3 |
| CLK3 | RGS7BP | 0.719134 | 3 | 0 | 3 |
| CLK3 | EIF3I | 0.717547 | 3 | 0 | 3 |
| CLK3 | RNF185 | 0.716982 | 3 | 0 | 3 |
| CLK3 | MEAF6 | 0.716065 | 3 | 0 | 3 |
| CLK3 | FIBCD1 | 0.714974 | 3 | 0 | 3 |
| CLK3 | RASGEF1B | 0.710309 | 3 | 0 | 3 |
| CLK3 | PROS1 | 0.708349 | 3 | 0 | 3 |
| CLK3 | AKIRIN2 | 0.706674 | 3 | 0 | 3 |
| CLK3 | UTS2R | 0.703795 | 3 | 0 | 3 |
| CLK3 | KRCC1 | 0.701973 | 3 | 0 | 3 |
| CLK3 | WDR93 | 0.699021 | 3 | 0 | 3 |
| CLK3 | UBE3A | 0.696584 | 3 | 0 | 3 |
| CLK3 | SPRY1 | 0.69327 | 4 | 0 | 3 |
| CLK3 | NUDT17 | 0.692613 | 3 | 0 | 3 |
For details and further investigation, click here
