| Full name: microtubule associated serine/threonine kinase family member 4 | Alias Symbol: KIAA0303 | ||
| Type: protein-coding gene | Cytoband: 5q12.3 | ||
| Entrez ID: 375449 | HGNC ID: HGNC:19037 | Ensembl Gene: ENSG00000069020 | OMIM ID: 618002 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MAST4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAST4 | 375449 | 40016_g_at | -0.6420 | 0.3393 | |
| GSE20347 | MAST4 | 375449 | 40016_g_at | -1.1805 | 0.0005 | |
| GSE23400 | MAST4 | 375449 | 40016_g_at | -0.8675 | 0.0000 | |
| GSE26886 | MAST4 | 375449 | 225613_at | -1.6723 | 0.0000 | |
| GSE29001 | MAST4 | 375449 | 40016_g_at | -1.3276 | 0.0002 | |
| GSE38129 | MAST4 | 375449 | 40016_g_at | -0.9674 | 0.0006 | |
| GSE45670 | MAST4 | 375449 | 225613_at | -0.4260 | 0.0456 | |
| GSE53622 | MAST4 | 375449 | 71671 | -1.7507 | 0.0000 | |
| GSE53624 | MAST4 | 375449 | 38452 | -1.1499 | 0.0000 | |
| GSE63941 | MAST4 | 375449 | 225611_at | -0.2409 | 0.7820 | |
| GSE77861 | MAST4 | 375449 | 40016_g_at | -0.6210 | 0.0586 | |
| GSE97050 | MAST4 | 375449 | A_23_P110571 | -0.0387 | 0.8845 | |
| SRP007169 | MAST4 | 375449 | RNAseq | -1.1420 | 0.0338 | |
| SRP008496 | MAST4 | 375449 | RNAseq | -1.1388 | 0.0004 | |
| SRP064894 | MAST4 | 375449 | RNAseq | -1.2806 | 0.0000 | |
| SRP133303 | MAST4 | 375449 | RNAseq | -1.2268 | 0.0000 | |
| SRP159526 | MAST4 | 375449 | RNAseq | -1.8259 | 0.0006 | |
| SRP193095 | MAST4 | 375449 | RNAseq | -0.7652 | 0.0021 | |
| SRP219564 | MAST4 | 375449 | RNAseq | -1.0570 | 0.0403 | |
| TCGA | MAST4 | 375449 | RNAseq | -0.0559 | 0.5517 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by MAST4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAST4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAST4 | 375449 | 0 | 13 | 17 | |
| GSE20123 | MAST4 | 375449 | 0 | 13 | 17 | |
| GSE43470 | MAST4 | 375449 | 1 | 12 | 30 | |
| GSE46452 | MAST4 | 375449 | 0 | 28 | 31 | |
| GSE47630 | MAST4 | 375449 | 2 | 17 | 21 | |
| GSE54993 | MAST4 | 375449 | 8 | 1 | 61 | |
| GSE54994 | MAST4 | 375449 | 1 | 19 | 33 | |
| GSE60625 | MAST4 | 375449 | 0 | 0 | 11 | |
| GSE74703 | MAST4 | 375449 | 1 | 9 | 26 | |
| GSE74704 | MAST4 | 375449 | 0 | 6 | 14 | |
| TCGA | MAST4 | 375449 | 4 | 51 | 41 |
Total number of gains: 17; Total number of losses: 169; Total Number of normals: 302.
Somatic mutations of MAST4:
Generating mutation plots.
Highly correlated genes for MAST4:
Showing top 20/897 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAST4 | FAM163B | 0.843096 | 3 | 0 | 3 |
| MAST4 | MFSD2B | 0.841512 | 3 | 0 | 3 |
| MAST4 | NCCRP1 | 0.814723 | 3 | 0 | 3 |
| MAST4 | KRTAP20-1 | 0.808517 | 3 | 0 | 3 |
| MAST4 | VSIG10L | 0.795057 | 7 | 0 | 7 |
| MAST4 | PTK6 | 0.794762 | 11 | 0 | 11 |
| MAST4 | OTOP3 | 0.790245 | 3 | 0 | 3 |
| MAST4 | EPS8L2 | 0.786857 | 12 | 0 | 11 |
| MAST4 | MUC22 | 0.78547 | 3 | 0 | 3 |
| MAST4 | OR2Z1 | 0.783159 | 3 | 0 | 3 |
| MAST4 | CYSRT1 | 0.782387 | 6 | 0 | 6 |
| MAST4 | SBSN | 0.777583 | 6 | 0 | 6 |
| MAST4 | S100A16 | 0.774336 | 6 | 0 | 6 |
| MAST4 | TMEM184A | 0.77302 | 4 | 0 | 4 |
| MAST4 | EVPL | 0.770115 | 11 | 0 | 11 |
| MAST4 | TEN1 | 0.764574 | 3 | 0 | 3 |
| MAST4 | BTBD9 | 0.764408 | 4 | 0 | 4 |
| MAST4 | DUOX1 | 0.764194 | 10 | 0 | 10 |
| MAST4 | CD164L2 | 0.763273 | 3 | 0 | 3 |
| MAST4 | PRSS27 | 0.761503 | 7 | 0 | 7 |
For details and further investigation, click here
