| Full name: dual oxidase 1 | Alias Symbol: NOXEF1|THOX1|LNOX1 | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 53905 | HGNC ID: HGNC:3062 | Ensembl Gene: ENSG00000137857 | OMIM ID: 606758 |
| Drug and gene relationship at DGIdb | |||
Expression of DUOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUOX1 | 53905 | 219597_s_at | -1.4664 | 0.2462 | |
| GSE20347 | DUOX1 | 53905 | 219597_s_at | -2.2893 | 0.0000 | |
| GSE23400 | DUOX1 | 53905 | 219597_s_at | -1.7579 | 0.0000 | |
| GSE26886 | DUOX1 | 53905 | 219597_s_at | -1.9996 | 0.0000 | |
| GSE29001 | DUOX1 | 53905 | 219597_s_at | -2.1940 | 0.0001 | |
| GSE38129 | DUOX1 | 53905 | 219597_s_at | -1.6317 | 0.0006 | |
| GSE45670 | DUOX1 | 53905 | 219597_s_at | -0.4712 | 0.1813 | |
| GSE53622 | DUOX1 | 53905 | 25970 | -1.6860 | 0.0000 | |
| GSE53624 | DUOX1 | 53905 | 25970 | -2.1418 | 0.0000 | |
| GSE63941 | DUOX1 | 53905 | 219597_s_at | 1.1571 | 0.0605 | |
| GSE77861 | DUOX1 | 53905 | 219597_s_at | -1.6801 | 0.0007 | |
| GSE97050 | DUOX1 | 53905 | A_23_P54291 | -0.4024 | 0.7153 | |
| SRP007169 | DUOX1 | 53905 | RNAseq | -3.0112 | 0.0000 | |
| SRP008496 | DUOX1 | 53905 | RNAseq | -3.2060 | 0.0000 | |
| SRP064894 | DUOX1 | 53905 | RNAseq | -2.0238 | 0.0000 | |
| SRP133303 | DUOX1 | 53905 | RNAseq | -2.0772 | 0.0000 | |
| SRP159526 | DUOX1 | 53905 | RNAseq | -2.2423 | 0.0000 | |
| SRP193095 | DUOX1 | 53905 | RNAseq | -1.4525 | 0.0000 | |
| SRP219564 | DUOX1 | 53905 | RNAseq | -2.3842 | 0.0245 | |
| TCGA | DUOX1 | 53905 | RNAseq | -0.1084 | 0.4339 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by DUOX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUOX1 | 53905 | 4 | 5 | 21 | |
| GSE20123 | DUOX1 | 53905 | 4 | 5 | 21 | |
| GSE43470 | DUOX1 | 53905 | 4 | 4 | 35 | |
| GSE46452 | DUOX1 | 53905 | 3 | 7 | 49 | |
| GSE47630 | DUOX1 | 53905 | 8 | 10 | 22 | |
| GSE54993 | DUOX1 | 53905 | 5 | 5 | 60 | |
| GSE54994 | DUOX1 | 53905 | 5 | 7 | 41 | |
| GSE60625 | DUOX1 | 53905 | 4 | 0 | 7 | |
| GSE74703 | DUOX1 | 53905 | 4 | 3 | 29 | |
| GSE74704 | DUOX1 | 53905 | 2 | 3 | 15 | |
| TCGA | DUOX1 | 53905 | 11 | 16 | 69 |
Total number of gains: 54; Total number of losses: 65; Total Number of normals: 369.
Somatic mutations of DUOX1:
Generating mutation plots.
Highly correlated genes for DUOX1:
Showing top 20/1634 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUOX1 | DUOXA1 | 0.874609 | 9 | 0 | 9 |
| DUOX1 | EVPL | 0.860197 | 13 | 0 | 12 |
| DUOX1 | CHP1 | 0.851607 | 10 | 0 | 10 |
| DUOX1 | EPS8L1 | 0.845959 | 12 | 0 | 12 |
| DUOX1 | CYSRT1 | 0.84181 | 6 | 0 | 6 |
| DUOX1 | TGM1 | 0.839958 | 12 | 0 | 12 |
| DUOX1 | CLIC3 | 0.839553 | 10 | 0 | 10 |
| DUOX1 | NIPAL1 | 0.837372 | 3 | 0 | 3 |
| DUOX1 | CWH43 | 0.831883 | 10 | 0 | 10 |
| DUOX1 | EPS8L2 | 0.828782 | 11 | 0 | 10 |
| DUOX1 | PPL | 0.82666 | 13 | 0 | 13 |
| DUOX1 | C6orf132 | 0.825697 | 8 | 0 | 8 |
| DUOX1 | GDPD3 | 0.824704 | 12 | 0 | 12 |
| DUOX1 | ARAP2 | 0.822668 | 3 | 0 | 3 |
| DUOX1 | CSTB | 0.821446 | 12 | 0 | 12 |
| DUOX1 | C1orf116 | 0.821214 | 13 | 0 | 12 |
| DUOX1 | NBEAL2 | 0.820641 | 12 | 0 | 12 |
| DUOX1 | SLC35C1 | 0.815966 | 10 | 0 | 10 |
| DUOX1 | MALL | 0.815666 | 12 | 0 | 12 |
| DUOX1 | CEACAM6 | 0.814243 | 11 | 0 | 11 |
For details and further investigation, click here
