| Full name: protein tyrosine kinase 6 | Alias Symbol: BRK | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 5753 | HGNC ID: HGNC:9617 | Ensembl Gene: ENSG00000101213 | OMIM ID: 602004 |
| Drug and gene relationship at DGIdb | |||
Expression of PTK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTK6 | 5753 | 1553114_a_at | -1.8158 | 0.1257 | |
| GSE20347 | PTK6 | 5753 | 206482_at | -3.1084 | 0.0000 | |
| GSE23400 | PTK6 | 5753 | 206482_at | -1.8539 | 0.0000 | |
| GSE26886 | PTK6 | 5753 | 1553114_a_at | -3.3397 | 0.0000 | |
| GSE29001 | PTK6 | 5753 | 206482_at | -2.3440 | 0.0000 | |
| GSE38129 | PTK6 | 5753 | 206482_at | -2.0601 | 0.0002 | |
| GSE45670 | PTK6 | 5753 | 206482_at | -1.0642 | 0.0192 | |
| GSE53622 | PTK6 | 5753 | 100896 | -1.3136 | 0.0000 | |
| GSE53624 | PTK6 | 5753 | 100896 | -2.1808 | 0.0000 | |
| GSE63941 | PTK6 | 5753 | 1553114_a_at | 0.9652 | 0.0140 | |
| GSE77861 | PTK6 | 5753 | 1553114_a_at | -1.0493 | 0.0027 | |
| GSE97050 | PTK6 | 5753 | A_23_P56978 | -0.0434 | 0.9257 | |
| SRP007169 | PTK6 | 5753 | RNAseq | -4.9758 | 0.0000 | |
| SRP008496 | PTK6 | 5753 | RNAseq | -4.8049 | 0.0000 | |
| SRP064894 | PTK6 | 5753 | RNAseq | -2.8233 | 0.0000 | |
| SRP133303 | PTK6 | 5753 | RNAseq | -2.6623 | 0.0000 | |
| SRP159526 | PTK6 | 5753 | RNAseq | -3.7542 | 0.0000 | |
| SRP193095 | PTK6 | 5753 | RNAseq | -2.6004 | 0.0000 | |
| SRP219564 | PTK6 | 5753 | RNAseq | -2.8989 | 0.0078 | |
| TCGA | PTK6 | 5753 | RNAseq | -0.0254 | 0.8979 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by PTK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTK6 | 5753 | 14 | 2 | 14 | |
| GSE20123 | PTK6 | 5753 | 14 | 2 | 14 | |
| GSE43470 | PTK6 | 5753 | 11 | 1 | 31 | |
| GSE46452 | PTK6 | 5753 | 35 | 0 | 24 | |
| GSE47630 | PTK6 | 5753 | 25 | 1 | 14 | |
| GSE54993 | PTK6 | 5753 | 0 | 17 | 53 | |
| GSE54994 | PTK6 | 5753 | 29 | 0 | 24 | |
| GSE60625 | PTK6 | 5753 | 0 | 0 | 11 | |
| GSE74703 | PTK6 | 5753 | 10 | 0 | 26 | |
| GSE74704 | PTK6 | 5753 | 11 | 0 | 9 | |
| TCGA | PTK6 | 5753 | 44 | 4 | 48 |
Total number of gains: 193; Total number of losses: 27; Total Number of normals: 268.
Somatic mutations of PTK6:
Generating mutation plots.
Highly correlated genes for PTK6:
Showing top 20/1079 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTK6 | FAM163B | 0.916088 | 3 | 0 | 3 |
| PTK6 | MFSD2B | 0.891483 | 3 | 0 | 3 |
| PTK6 | CYSRT1 | 0.888848 | 7 | 0 | 7 |
| PTK6 | CLIC3 | 0.874885 | 9 | 0 | 9 |
| PTK6 | EPS8L2 | 0.871317 | 12 | 0 | 11 |
| PTK6 | VSIG10L | 0.87015 | 7 | 0 | 7 |
| PTK6 | OR2Z1 | 0.862143 | 3 | 0 | 3 |
| PTK6 | KRTAP20-1 | 0.861983 | 3 | 0 | 3 |
| PTK6 | TGM1 | 0.861956 | 11 | 0 | 11 |
| PTK6 | MUC22 | 0.856992 | 3 | 0 | 3 |
| PTK6 | ATG9B | 0.856209 | 6 | 0 | 6 |
| PTK6 | CWH43 | 0.855555 | 10 | 0 | 10 |
| PTK6 | SCNN1B | 0.851905 | 11 | 0 | 11 |
| PTK6 | RANBP9 | 0.850904 | 10 | 0 | 10 |
| PTK6 | SLC35C1 | 0.844483 | 11 | 0 | 11 |
| PTK6 | IL18 | 0.843047 | 11 | 0 | 11 |
| PTK6 | CRCT1 | 0.842531 | 12 | 0 | 12 |
| PTK6 | GYS2 | 0.841686 | 10 | 0 | 10 |
| PTK6 | ENDOU | 0.840471 | 11 | 0 | 10 |
| PTK6 | TEN1 | 0.835969 | 3 | 0 | 3 |
For details and further investigation, click here
