S100A16

 

Full name: S100 calcium binding protein A16 Alias Symbol: S100F|DT1P1A7|MGC17528
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 140576 HGNC ID: HGNC:20441 Ensembl Gene: ENSG00000188643 OMIM ID: 617437
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of S100A16:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 S100A16 140576 227998_at -0.5440 0.3728
GSE26886 S100A16 140576 227998_at -2.0990 0.0000
GSE45670 S100A16 140576 227998_at -0.4065 0.0305
GSE53622 S100A16 140576 50405 -1.4674 0.0000
GSE53624 S100A16 140576 50405 -1.7523 0.0000
GSE63941 S100A16 140576 227998_at 0.8344 0.2895
GSE77861 S100A16 140576 227998_at -0.7571 0.0042
GSE97050 S100A16 140576 A_23_P147918 -0.1448 0.8945
SRP007169 S100A16 140576 RNAseq -4.1291 0.0000
SRP008496 S100A16 140576 RNAseq -3.7161 0.0000
SRP064894 S100A16 140576 RNAseq -2.3363 0.0000
SRP133303 S100A16 140576 RNAseq -2.0750 0.0000
SRP159526 S100A16 140576 RNAseq -2.5460 0.0000
SRP193095 S100A16 140576 RNAseq -2.3322 0.0000
SRP219564 S100A16 140576 RNAseq -2.0963 0.0108
TCGA S100A16 140576 RNAseq 0.3376 0.0002

Upregulated datasets: 0; Downregulated datasets: 10.  

 

Survival by S100A16 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of S100A16:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 S100A16 140576 14 0 16
GSE20123 S100A16 140576 14 0 16
GSE43470 S100A16 140576 7 2 34
GSE46452 S100A16 140576 2 1 56
GSE47630 S100A16 140576 14 0 26
GSE54993 S100A16 140576 0 4 66
GSE54994 S100A16 140576 16 0 37
GSE60625 S100A16 140576 0 0 11
GSE74703 S100A16 140576 6 1 29
GSE74704 S100A16 140576 7 0 13
TCGA S100A16 140576 38 2 56

Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.  

 

Somatic mutations of S100A16:

 

Generating mutation plots.

 

Highly correlated genes for S100A16:

 

Showing top 20/1582 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
S100A16EVPL0.913859707
S100A16CSTB0.873459808
S100A16CYSRT10.871645606
S100A16BTBD110.867508707
S100A16S100A140.848307909
S100A16IL180.844249707
S100A16GRHL30.836915808
S100A16C5orf66-AS10.830588606
S100A16IL1RN0.830431807
S100A16MALL0.828377908
S100A16TP53I30.827974707
S100A16TMEM1540.823957807
S100A16ANXA10.821325807
S100A16GPR1570.821118707
S100A16PADI10.820516404
S100A16ZNF1850.819528909
S100A16PKP30.819032808
S100A16RBM470.818578707
S100A16PDLIM20.818133404
S100A16EPS8L20.815989706

For details and further investigation, click here