| Full name: envoplakin | Alias Symbol: EVPK | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 2125 | HGNC ID: HGNC:3503 | Ensembl Gene: ENSG00000167880 | OMIM ID: 601590 |
| Drug and gene relationship at DGIdb | |||
Expression of EVPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EVPL | 2125 | 204503_at | -1.5037 | 0.1758 | |
| GSE20347 | EVPL | 2125 | 204503_at | -2.3735 | 0.0000 | |
| GSE23400 | EVPL | 2125 | 204503_at | -1.7377 | 0.0000 | |
| GSE26886 | EVPL | 2125 | 204503_at | -2.4982 | 0.0000 | |
| GSE29001 | EVPL | 2125 | 204503_at | -1.8482 | 0.0000 | |
| GSE38129 | EVPL | 2125 | 204503_at | -1.7636 | 0.0001 | |
| GSE45670 | EVPL | 2125 | 204503_at | -0.7264 | 0.0337 | |
| GSE53622 | EVPL | 2125 | 39064 | -2.3199 | 0.0000 | |
| GSE53624 | EVPL | 2125 | 39064 | -2.6996 | 0.0000 | |
| GSE63941 | EVPL | 2125 | 204503_at | 0.8127 | 0.0116 | |
| GSE77861 | EVPL | 2125 | 204503_at | -1.2508 | 0.0038 | |
| GSE97050 | EVPL | 2125 | A_24_P104512 | -0.4582 | 0.6160 | |
| SRP007169 | EVPL | 2125 | RNAseq | -2.5557 | 0.0000 | |
| SRP008496 | EVPL | 2125 | RNAseq | -2.7944 | 0.0000 | |
| SRP064894 | EVPL | 2125 | RNAseq | -2.8069 | 0.0000 | |
| SRP133303 | EVPL | 2125 | RNAseq | -2.7274 | 0.0000 | |
| SRP159526 | EVPL | 2125 | RNAseq | -3.3940 | 0.0000 | |
| SRP193095 | EVPL | 2125 | RNAseq | -2.5312 | 0.0000 | |
| SRP219564 | EVPL | 2125 | RNAseq | -3.5480 | 0.0023 | |
| TCGA | EVPL | 2125 | RNAseq | 0.4970 | 0.0015 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by EVPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EVPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EVPL | 2125 | 7 | 2 | 21 | |
| GSE20123 | EVPL | 2125 | 7 | 2 | 21 | |
| GSE43470 | EVPL | 2125 | 5 | 3 | 35 | |
| GSE46452 | EVPL | 2125 | 34 | 0 | 25 | |
| GSE47630 | EVPL | 2125 | 8 | 1 | 31 | |
| GSE54993 | EVPL | 2125 | 2 | 5 | 63 | |
| GSE54994 | EVPL | 2125 | 10 | 4 | 39 | |
| GSE60625 | EVPL | 2125 | 6 | 0 | 5 | |
| GSE74703 | EVPL | 2125 | 5 | 1 | 30 | |
| GSE74704 | EVPL | 2125 | 5 | 1 | 14 | |
| TCGA | EVPL | 2125 | 31 | 10 | 55 |
Total number of gains: 120; Total number of losses: 29; Total Number of normals: 339.
Somatic mutations of EVPL:
Generating mutation plots.
Highly correlated genes for EVPL:
Showing top 20/1557 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EVPL | S100A16 | 0.913859 | 7 | 0 | 7 |
| EVPL | CYSRT1 | 0.907377 | 6 | 0 | 6 |
| EVPL | CLIC3 | 0.881368 | 10 | 0 | 10 |
| EVPL | TMEM40 | 0.880635 | 12 | 0 | 12 |
| EVPL | PPL | 0.877399 | 13 | 0 | 13 |
| EVPL | MALL | 0.876529 | 12 | 0 | 12 |
| EVPL | GBP6 | 0.874943 | 4 | 0 | 4 |
| EVPL | MXD1 | 0.871238 | 11 | 0 | 11 |
| EVPL | EPS8L1 | 0.864453 | 13 | 0 | 13 |
| EVPL | IL1RN | 0.863147 | 12 | 0 | 12 |
| EVPL | C6orf132 | 0.862641 | 8 | 0 | 8 |
| EVPL | TGM1 | 0.862534 | 12 | 0 | 12 |
| EVPL | VSIG10L | 0.861797 | 7 | 0 | 7 |
| EVPL | DUOX1 | 0.860197 | 13 | 0 | 12 |
| EVPL | CHP1 | 0.857402 | 10 | 0 | 10 |
| EVPL | EPS8L2 | 0.856072 | 12 | 0 | 11 |
| EVPL | TMOD3 | 0.855787 | 11 | 0 | 11 |
| EVPL | TTC9 | 0.854247 | 11 | 0 | 11 |
| EVPL | SLURP1 | 0.854237 | 12 | 0 | 12 |
| EVPL | TMPRSS11E | 0.852452 | 11 | 0 | 11 |
For details and further investigation, click here
