| Full name: methyl-CpG binding domain protein 6 | Alias Symbol: KIAA1887 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 114785 | HGNC ID: HGNC:20445 | Ensembl Gene: ENSG00000166987 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of MBD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBD6 | 114785 | 227833_s_at | 0.4379 | 0.3109 | |
| GSE26886 | MBD6 | 114785 | 227833_s_at | 0.5710 | 0.0238 | |
| GSE45670 | MBD6 | 114785 | 227833_s_at | 0.2746 | 0.0577 | |
| GSE53622 | MBD6 | 114785 | 59601 | 0.0740 | 0.1712 | |
| GSE53624 | MBD6 | 114785 | 27177 | 0.2235 | 0.0000 | |
| GSE63941 | MBD6 | 114785 | 227833_s_at | 0.7746 | 0.1373 | |
| GSE77861 | MBD6 | 114785 | 227832_at | -0.0981 | 0.5293 | |
| GSE97050 | MBD6 | 114785 | A_33_P3224027 | 0.1865 | 0.4374 | |
| SRP007169 | MBD6 | 114785 | RNAseq | 0.7307 | 0.0874 | |
| SRP008496 | MBD6 | 114785 | RNAseq | 0.1395 | 0.5802 | |
| SRP064894 | MBD6 | 114785 | RNAseq | 0.4606 | 0.0348 | |
| SRP133303 | MBD6 | 114785 | RNAseq | 0.2334 | 0.2457 | |
| SRP159526 | MBD6 | 114785 | RNAseq | 0.4816 | 0.0419 | |
| SRP193095 | MBD6 | 114785 | RNAseq | 0.4777 | 0.0118 | |
| SRP219564 | MBD6 | 114785 | RNAseq | 0.2937 | 0.4297 | |
| TCGA | MBD6 | 114785 | RNAseq | 0.0054 | 0.9020 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MBD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBD6 | 114785 | 7 | 1 | 22 | |
| GSE20123 | MBD6 | 114785 | 7 | 0 | 23 | |
| GSE43470 | MBD6 | 114785 | 2 | 0 | 41 | |
| GSE46452 | MBD6 | 114785 | 8 | 1 | 50 | |
| GSE47630 | MBD6 | 114785 | 10 | 2 | 28 | |
| GSE54993 | MBD6 | 114785 | 0 | 5 | 65 | |
| GSE54994 | MBD6 | 114785 | 4 | 1 | 48 | |
| GSE60625 | MBD6 | 114785 | 0 | 0 | 11 | |
| GSE74703 | MBD6 | 114785 | 2 | 0 | 34 | |
| GSE74704 | MBD6 | 114785 | 5 | 0 | 15 | |
| TCGA | MBD6 | 114785 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of MBD6:
Generating mutation plots.
Highly correlated genes for MBD6:
Showing top 20/240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBD6 | PRPF31 | 0.839676 | 3 | 0 | 3 |
| MBD6 | LONP1 | 0.797882 | 3 | 0 | 3 |
| MBD6 | NAT8B | 0.766396 | 3 | 0 | 3 |
| MBD6 | RBM28 | 0.763433 | 3 | 0 | 3 |
| MBD6 | STK11 | 0.756313 | 3 | 0 | 3 |
| MBD6 | STK32C | 0.748497 | 3 | 0 | 3 |
| MBD6 | TRIM31 | 0.741874 | 3 | 0 | 3 |
| MBD6 | RTN4RL1 | 0.734756 | 3 | 0 | 3 |
| MBD6 | CEMP1 | 0.727278 | 3 | 0 | 3 |
| MBD6 | FBRSL1 | 0.718546 | 4 | 0 | 4 |
| MBD6 | NOC4L | 0.718416 | 3 | 0 | 3 |
| MBD6 | CNOT3 | 0.718413 | 4 | 0 | 3 |
| MBD6 | RASL10B | 0.703244 | 3 | 0 | 3 |
| MBD6 | BTBD19 | 0.698898 | 3 | 0 | 3 |
| MBD6 | FUT1 | 0.698565 | 3 | 0 | 3 |
| MBD6 | POLR3A | 0.694982 | 3 | 0 | 3 |
| MBD6 | HDAC8 | 0.694501 | 3 | 0 | 3 |
| MBD6 | SLC26A1 | 0.693944 | 3 | 0 | 3 |
| MBD6 | JSRP1 | 0.690318 | 3 | 0 | 3 |
| MBD6 | GMIP | 0.68872 | 4 | 0 | 3 |
For details and further investigation, click here
