| Full name: myocyte enhancer factor 2C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.3 | ||
| Entrez ID: 4208 | HGNC ID: HGNC:6996 | Ensembl Gene: ENSG00000081189 | OMIM ID: 600662 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MEF2C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04921 | Oxytocin signaling pathway |
Expression of MEF2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEF2C | 4208 | 209199_s_at | -0.6425 | 0.4328 | |
| GSE20347 | MEF2C | 4208 | 209199_s_at | -0.0781 | 0.6844 | |
| GSE23400 | MEF2C | 4208 | 209199_s_at | -0.1343 | 0.3180 | |
| GSE26886 | MEF2C | 4208 | 209200_at | -0.2075 | 0.5797 | |
| GSE29001 | MEF2C | 4208 | 209199_s_at | 0.1877 | 0.6788 | |
| GSE38129 | MEF2C | 4208 | 209199_s_at | -0.5442 | 0.1020 | |
| GSE45670 | MEF2C | 4208 | 209199_s_at | -1.4686 | 0.0003 | |
| GSE53622 | MEF2C | 4208 | 90762 | -0.6346 | 0.0000 | |
| GSE53624 | MEF2C | 4208 | 90762 | -0.6314 | 0.0000 | |
| GSE63941 | MEF2C | 4208 | 209199_s_at | -1.5960 | 0.1039 | |
| GSE77861 | MEF2C | 4208 | 209200_at | 0.2171 | 0.0441 | |
| GSE97050 | MEF2C | 4208 | A_23_P320739 | -0.0114 | 0.9667 | |
| SRP007169 | MEF2C | 4208 | RNAseq | 1.1670 | 0.0154 | |
| SRP008496 | MEF2C | 4208 | RNAseq | 1.7395 | 0.0000 | |
| SRP064894 | MEF2C | 4208 | RNAseq | 0.3934 | 0.1801 | |
| SRP133303 | MEF2C | 4208 | RNAseq | -0.5902 | 0.0136 | |
| SRP159526 | MEF2C | 4208 | RNAseq | -0.5699 | 0.1756 | |
| SRP193095 | MEF2C | 4208 | RNAseq | 0.2389 | 0.4350 | |
| SRP219564 | MEF2C | 4208 | RNAseq | -0.0595 | 0.9230 | |
| TCGA | MEF2C | 4208 | RNAseq | -0.2939 | 0.0070 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by MEF2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEF2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEF2C | 4208 | 1 | 14 | 15 | |
| GSE20123 | MEF2C | 4208 | 1 | 14 | 15 | |
| GSE43470 | MEF2C | 4208 | 2 | 10 | 31 | |
| GSE46452 | MEF2C | 4208 | 0 | 28 | 31 | |
| GSE47630 | MEF2C | 4208 | 1 | 20 | 19 | |
| GSE54993 | MEF2C | 4208 | 8 | 1 | 61 | |
| GSE54994 | MEF2C | 4208 | 1 | 18 | 34 | |
| GSE60625 | MEF2C | 4208 | 0 | 0 | 11 | |
| GSE74703 | MEF2C | 4208 | 1 | 8 | 27 | |
| GSE74704 | MEF2C | 4208 | 1 | 7 | 12 | |
| TCGA | MEF2C | 4208 | 2 | 49 | 45 |
Total number of gains: 18; Total number of losses: 169; Total Number of normals: 301.
Somatic mutations of MEF2C:
Generating mutation plots.
Highly correlated genes for MEF2C:
Showing top 20/417 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEF2C | MEOX2 | 0.769997 | 7 | 0 | 7 |
| MEF2C | ZEB2 | 0.734463 | 11 | 0 | 11 |
| MEF2C | LINC01279 | 0.733717 | 4 | 0 | 4 |
| MEF2C | RASGRP2 | 0.731253 | 5 | 0 | 4 |
| MEF2C | FGF10 | 0.71848 | 4 | 0 | 4 |
| MEF2C | JAM2 | 0.712653 | 11 | 0 | 10 |
| MEF2C | C3 | 0.710569 | 9 | 0 | 8 |
| MEF2C | RCAN2 | 0.706485 | 11 | 0 | 9 |
| MEF2C | MAGI2-AS3 | 0.706462 | 6 | 0 | 6 |
| MEF2C | OGN | 0.706226 | 8 | 0 | 8 |
| MEF2C | SPARCL1 | 0.696281 | 10 | 0 | 9 |
| MEF2C | C1QTNF7 | 0.69503 | 4 | 0 | 4 |
| MEF2C | LDB2 | 0.686222 | 13 | 0 | 12 |
| MEF2C | CREBRF | 0.685851 | 3 | 0 | 3 |
| MEF2C | TCEAL1 | 0.685682 | 7 | 0 | 7 |
| MEF2C | PLN | 0.685245 | 10 | 0 | 9 |
| MEF2C | TESC | 0.684817 | 6 | 0 | 5 |
| MEF2C | S100A4 | 0.678307 | 7 | 0 | 7 |
| MEF2C | ENTPD1 | 0.678084 | 12 | 0 | 10 |
| MEF2C | RANGRF | 0.677909 | 3 | 0 | 3 |
For details and further investigation, click here
