JAM2

 

Full name: junctional adhesion molecule 2 Alias Symbol: VE-JAM|JAM-B|JAMB|CD322
Type: protein-coding gene Cytoband: 21q21.3
Entrez ID: 58494 HGNC ID: HGNC:14686 Ensembl Gene: ENSG00000154721 OMIM ID: 606870
Drug and gene relationship at DGIdb

 

JAM2 involved pathways:

KEGG pathway Description View
hsa04530Tight junction

 

Expression of JAM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 JAM2 58494 219213_at -1.1248 0.2334
GSE20347 JAM2 58494 219213_at -0.5406 0.0021
GSE23400 JAM2 58494 219213_at -0.4183 0.0002
GSE26886 JAM2 58494 219213_at -0.7690 0.0076
GSE29001 JAM2 58494 219213_at -0.4936 0.0676
GSE38129 JAM2 58494 219213_at -1.0686 0.0012
GSE45670 JAM2 58494 219213_at -2.0819 0.0000
GSE53622 JAM2 58494 51599 -1.5284 0.0000
GSE53624 JAM2 58494 51599 -1.3190 0.0000
GSE63941 JAM2 58494 219213_at -3.2586 0.0000
GSE77861 JAM2 58494 219213_at -0.1188 0.5529
GSE97050 JAM2 58494 A_33_P3226212 -1.2754 0.0781
SRP007169 JAM2 58494 RNAseq 0.7768 0.2148
SRP064894 JAM2 58494 RNAseq -0.3634 0.2507
SRP133303 JAM2 58494 RNAseq -1.5583 0.0000
SRP159526 JAM2 58494 RNAseq -0.7428 0.0346
SRP193095 JAM2 58494 RNAseq -0.4706 0.0072
SRP219564 JAM2 58494 RNAseq -0.4221 0.6237
TCGA JAM2 58494 RNAseq -0.9632 0.0000

Upregulated datasets: 0; Downregulated datasets: 6.  


 

Survival by JAM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of JAM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 JAM2 58494 2 11 17
GSE20123 JAM2 58494 2 11 17
GSE43470 JAM2 58494 2 8 33
GSE46452 JAM2 58494 1 21 37
GSE47630 JAM2 58494 6 17 17
GSE54993 JAM2 58494 9 2 59
GSE54994 JAM2 58494 2 8 43
GSE60625 JAM2 58494 0 0 11
GSE74703 JAM2 58494 2 6 28
GSE74704 JAM2 58494 2 7 11
TCGA JAM2 58494 9 38 49

Total number of gains: 37; Total number of losses: 129; Total Number of normals: 322.  


 

Somatic mutations of JAM2:

 

Generating mutation plots.

 

Highly correlated genes for JAM2:

 

Showing top 20/1367 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
JAM2FAM13C0.862337505
JAM2UBXN100.855964303
JAM2SORCS10.855167404
JAM2MEOX20.854109808
JAM2PREX20.84395404
JAM2XKR40.840156505
JAM2ARHGAP60.83734810010
JAM2KCNT20.837207606
JAM2MRVI10.835026707
JAM2CYP21A20.819942303
JAM2INMT0.813401606
JAM2TEK0.813005606
JAM2RUNX1T10.812744808
JAM2CLEC3B0.80776303
JAM2SMIM100.800887505
JAM2EBF10.799631707
JAM2C3orf700.796924505
JAM2FRMD30.796078505
JAM2ASPA0.79485211011
JAM2SMTN0.792251606

For details and further investigation, click here