| Full name: junctional adhesion molecule 2 | Alias Symbol: VE-JAM|JAM-B|JAMB|CD322 | ||
| Type: protein-coding gene | Cytoband: 21q21.3 | ||
| Entrez ID: 58494 | HGNC ID: HGNC:14686 | Ensembl Gene: ENSG00000154721 | OMIM ID: 606870 |
| Drug and gene relationship at DGIdb | |||
JAM2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of JAM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | JAM2 | 58494 | 219213_at | -1.1248 | 0.2334 | |
| GSE20347 | JAM2 | 58494 | 219213_at | -0.5406 | 0.0021 | |
| GSE23400 | JAM2 | 58494 | 219213_at | -0.4183 | 0.0002 | |
| GSE26886 | JAM2 | 58494 | 219213_at | -0.7690 | 0.0076 | |
| GSE29001 | JAM2 | 58494 | 219213_at | -0.4936 | 0.0676 | |
| GSE38129 | JAM2 | 58494 | 219213_at | -1.0686 | 0.0012 | |
| GSE45670 | JAM2 | 58494 | 219213_at | -2.0819 | 0.0000 | |
| GSE53622 | JAM2 | 58494 | 51599 | -1.5284 | 0.0000 | |
| GSE53624 | JAM2 | 58494 | 51599 | -1.3190 | 0.0000 | |
| GSE63941 | JAM2 | 58494 | 219213_at | -3.2586 | 0.0000 | |
| GSE77861 | JAM2 | 58494 | 219213_at | -0.1188 | 0.5529 | |
| GSE97050 | JAM2 | 58494 | A_33_P3226212 | -1.2754 | 0.0781 | |
| SRP007169 | JAM2 | 58494 | RNAseq | 0.7768 | 0.2148 | |
| SRP064894 | JAM2 | 58494 | RNAseq | -0.3634 | 0.2507 | |
| SRP133303 | JAM2 | 58494 | RNAseq | -1.5583 | 0.0000 | |
| SRP159526 | JAM2 | 58494 | RNAseq | -0.7428 | 0.0346 | |
| SRP193095 | JAM2 | 58494 | RNAseq | -0.4706 | 0.0072 | |
| SRP219564 | JAM2 | 58494 | RNAseq | -0.4221 | 0.6237 | |
| TCGA | JAM2 | 58494 | RNAseq | -0.9632 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by JAM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of JAM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | JAM2 | 58494 | 2 | 11 | 17 | |
| GSE20123 | JAM2 | 58494 | 2 | 11 | 17 | |
| GSE43470 | JAM2 | 58494 | 2 | 8 | 33 | |
| GSE46452 | JAM2 | 58494 | 1 | 21 | 37 | |
| GSE47630 | JAM2 | 58494 | 6 | 17 | 17 | |
| GSE54993 | JAM2 | 58494 | 9 | 2 | 59 | |
| GSE54994 | JAM2 | 58494 | 2 | 8 | 43 | |
| GSE60625 | JAM2 | 58494 | 0 | 0 | 11 | |
| GSE74703 | JAM2 | 58494 | 2 | 6 | 28 | |
| GSE74704 | JAM2 | 58494 | 2 | 7 | 11 | |
| TCGA | JAM2 | 58494 | 9 | 38 | 49 |
Total number of gains: 37; Total number of losses: 129; Total Number of normals: 322.
Somatic mutations of JAM2:
Generating mutation plots.
Highly correlated genes for JAM2:
Showing top 20/1367 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| JAM2 | FAM13C | 0.862337 | 5 | 0 | 5 |
| JAM2 | UBXN10 | 0.855964 | 3 | 0 | 3 |
| JAM2 | SORCS1 | 0.855167 | 4 | 0 | 4 |
| JAM2 | MEOX2 | 0.854109 | 8 | 0 | 8 |
| JAM2 | PREX2 | 0.84395 | 4 | 0 | 4 |
| JAM2 | XKR4 | 0.840156 | 5 | 0 | 5 |
| JAM2 | ARHGAP6 | 0.837348 | 10 | 0 | 10 |
| JAM2 | KCNT2 | 0.837207 | 6 | 0 | 6 |
| JAM2 | MRVI1 | 0.835026 | 7 | 0 | 7 |
| JAM2 | CYP21A2 | 0.819942 | 3 | 0 | 3 |
| JAM2 | INMT | 0.813401 | 6 | 0 | 6 |
| JAM2 | TEK | 0.813005 | 6 | 0 | 6 |
| JAM2 | RUNX1T1 | 0.812744 | 8 | 0 | 8 |
| JAM2 | CLEC3B | 0.80776 | 3 | 0 | 3 |
| JAM2 | SMIM10 | 0.800887 | 5 | 0 | 5 |
| JAM2 | EBF1 | 0.799631 | 7 | 0 | 7 |
| JAM2 | C3orf70 | 0.796924 | 5 | 0 | 5 |
| JAM2 | FRMD3 | 0.796078 | 5 | 0 | 5 |
| JAM2 | ASPA | 0.794852 | 11 | 0 | 11 |
| JAM2 | SMTN | 0.792251 | 6 | 0 | 6 |
For details and further investigation, click here
