| Full name: SPARC like 1 | Alias Symbol: MAST9 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 8404 | HGNC ID: HGNC:11220 | Ensembl Gene: ENSG00000152583 | OMIM ID: 606041 |
| Drug and gene relationship at DGIdb | |||
Expression of SPARCL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPARCL1 | 8404 | 200795_at | -1.3331 | 0.2682 | |
| GSE20347 | SPARCL1 | 8404 | 200795_at | -0.4351 | 0.2852 | |
| GSE23400 | SPARCL1 | 8404 | 200795_at | -0.5425 | 0.0093 | |
| GSE26886 | SPARCL1 | 8404 | 200795_at | 0.3143 | 0.5770 | |
| GSE29001 | SPARCL1 | 8404 | 200795_at | -0.9095 | 0.1470 | |
| GSE38129 | SPARCL1 | 8404 | 200795_at | -0.7794 | 0.0812 | |
| GSE45670 | SPARCL1 | 8404 | 200795_at | -2.3648 | 0.0000 | |
| GSE53622 | SPARCL1 | 8404 | 66437 | -1.2307 | 0.0000 | |
| GSE53624 | SPARCL1 | 8404 | 66437 | -0.9930 | 0.0000 | |
| GSE63941 | SPARCL1 | 8404 | 200795_at | 1.2044 | 0.4198 | |
| GSE77861 | SPARCL1 | 8404 | 200795_at | 0.2798 | 0.6033 | |
| GSE97050 | SPARCL1 | 8404 | A_23_P113351 | -1.5360 | 0.0880 | |
| SRP007169 | SPARCL1 | 8404 | RNAseq | 0.6526 | 0.0788 | |
| SRP008496 | SPARCL1 | 8404 | RNAseq | 1.1526 | 0.0002 | |
| SRP064894 | SPARCL1 | 8404 | RNAseq | -0.0272 | 0.9463 | |
| SRP133303 | SPARCL1 | 8404 | RNAseq | -1.7852 | 0.0000 | |
| SRP159526 | SPARCL1 | 8404 | RNAseq | -0.4908 | 0.2119 | |
| SRP193095 | SPARCL1 | 8404 | RNAseq | 0.1182 | 0.6544 | |
| SRP219564 | SPARCL1 | 8404 | RNAseq | -0.6486 | 0.5208 | |
| TCGA | SPARCL1 | 8404 | RNAseq | -0.5082 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by SPARCL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPARCL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPARCL1 | 8404 | 3 | 12 | 15 | |
| GSE20123 | SPARCL1 | 8404 | 3 | 12 | 15 | |
| GSE43470 | SPARCL1 | 8404 | 0 | 13 | 30 | |
| GSE46452 | SPARCL1 | 8404 | 2 | 35 | 22 | |
| GSE47630 | SPARCL1 | 8404 | 0 | 20 | 20 | |
| GSE54993 | SPARCL1 | 8404 | 8 | 0 | 62 | |
| GSE54994 | SPARCL1 | 8404 | 1 | 9 | 43 | |
| GSE60625 | SPARCL1 | 8404 | 0 | 0 | 11 | |
| GSE74703 | SPARCL1 | 8404 | 0 | 11 | 25 | |
| GSE74704 | SPARCL1 | 8404 | 2 | 7 | 11 | |
| TCGA | SPARCL1 | 8404 | 12 | 36 | 48 |
Total number of gains: 31; Total number of losses: 155; Total Number of normals: 302.
Somatic mutations of SPARCL1:
Generating mutation plots.
Highly correlated genes for SPARCL1:
Showing top 20/944 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPARCL1 | AKAP12 | 0.806505 | 8 | 0 | 8 |
| SPARCL1 | FIBIN | 0.785608 | 3 | 0 | 3 |
| SPARCL1 | KCNT2 | 0.779038 | 6 | 0 | 6 |
| SPARCL1 | CLEC3B | 0.775525 | 3 | 0 | 3 |
| SPARCL1 | PTGIS | 0.774854 | 10 | 0 | 10 |
| SPARCL1 | SORCS1 | 0.774806 | 4 | 0 | 4 |
| SPARCL1 | PPP1R12B | 0.774233 | 11 | 0 | 11 |
| SPARCL1 | ABCA8 | 0.773202 | 9 | 0 | 8 |
| SPARCL1 | PLN | 0.772557 | 12 | 0 | 11 |
| SPARCL1 | FENDRR | 0.772144 | 4 | 0 | 4 |
| SPARCL1 | ADAMTS9-AS2 | 0.771096 | 4 | 0 | 4 |
| SPARCL1 | SYNPO2 | 0.766004 | 8 | 0 | 6 |
| SPARCL1 | KCTD12 | 0.765474 | 9 | 0 | 9 |
| SPARCL1 | CYP21A2 | 0.762345 | 3 | 0 | 3 |
| SPARCL1 | DPT | 0.760034 | 8 | 0 | 8 |
| SPARCL1 | UBXN10 | 0.759353 | 3 | 0 | 3 |
| SPARCL1 | MFAP4 | 0.759254 | 10 | 0 | 9 |
| SPARCL1 | ACTA2 | 0.758572 | 12 | 0 | 11 |
| SPARCL1 | ACTBL2 | 0.754592 | 3 | 0 | 3 |
| SPARCL1 | ITGA7 | 0.754363 | 10 | 0 | 10 |
For details and further investigation, click here
