| Full name: regulator of calcineurin 2 | Alias Symbol: ZAKI-4 | ||
| Type: protein-coding gene | Cytoband: 6p12.3 | ||
| Entrez ID: 10231 | HGNC ID: HGNC:3041 | Ensembl Gene: ENSG00000172348 | OMIM ID: 604876 |
| Drug and gene relationship at DGIdb | |||
RCAN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04919 | Thyroid hormone signaling pathway |
Expression of RCAN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RCAN2 | 10231 | 203498_at | -1.9513 | 0.0603 | |
| GSE20347 | RCAN2 | 10231 | 203498_at | -0.7947 | 0.0125 | |
| GSE23400 | RCAN2 | 10231 | 203498_at | -1.3960 | 0.0000 | |
| GSE26886 | RCAN2 | 10231 | 203498_at | 0.3091 | 0.5076 | |
| GSE29001 | RCAN2 | 10231 | 203498_at | -1.4918 | 0.0060 | |
| GSE38129 | RCAN2 | 10231 | 203498_at | -1.7388 | 0.0019 | |
| GSE45670 | RCAN2 | 10231 | 203498_at | -3.3206 | 0.0000 | |
| GSE53622 | RCAN2 | 10231 | 90465 | -2.7465 | 0.0000 | |
| GSE53624 | RCAN2 | 10231 | 90465 | -2.3502 | 0.0000 | |
| GSE63941 | RCAN2 | 10231 | 203498_at | -6.2773 | 0.0000 | |
| GSE77861 | RCAN2 | 10231 | 203498_at | 0.1236 | 0.5040 | |
| GSE97050 | RCAN2 | 10231 | A_33_P3230818 | -1.6030 | 0.1657 | |
| SRP007169 | RCAN2 | 10231 | RNAseq | -0.0370 | 0.9371 | |
| SRP008496 | RCAN2 | 10231 | RNAseq | 0.8460 | 0.0575 | |
| SRP064894 | RCAN2 | 10231 | RNAseq | -1.1002 | 0.0022 | |
| SRP133303 | RCAN2 | 10231 | RNAseq | -1.6887 | 0.0000 | |
| SRP159526 | RCAN2 | 10231 | RNAseq | -1.4929 | 0.0016 | |
| SRP193095 | RCAN2 | 10231 | RNAseq | -0.0454 | 0.9057 | |
| SRP219564 | RCAN2 | 10231 | RNAseq | -0.6362 | 0.5121 | |
| TCGA | RCAN2 | 10231 | RNAseq | -1.0382 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by RCAN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RCAN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RCAN2 | 10231 | 6 | 2 | 22 | |
| GSE20123 | RCAN2 | 10231 | 6 | 2 | 22 | |
| GSE43470 | RCAN2 | 10231 | 6 | 0 | 37 | |
| GSE46452 | RCAN2 | 10231 | 2 | 10 | 47 | |
| GSE47630 | RCAN2 | 10231 | 7 | 5 | 28 | |
| GSE54993 | RCAN2 | 10231 | 3 | 1 | 66 | |
| GSE54994 | RCAN2 | 10231 | 8 | 3 | 42 | |
| GSE60625 | RCAN2 | 10231 | 0 | 3 | 8 | |
| GSE74703 | RCAN2 | 10231 | 6 | 0 | 30 | |
| GSE74704 | RCAN2 | 10231 | 2 | 1 | 17 | |
| TCGA | RCAN2 | 10231 | 17 | 14 | 65 |
Total number of gains: 63; Total number of losses: 41; Total Number of normals: 384.
Somatic mutations of RCAN2:
Generating mutation plots.
Highly correlated genes for RCAN2:
Showing top 20/1480 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RCAN2 | CLEC3B | 0.910701 | 3 | 0 | 3 |
| RCAN2 | CYP21A2 | 0.905259 | 3 | 0 | 3 |
| RCAN2 | ARHGAP6 | 0.895214 | 10 | 0 | 10 |
| RCAN2 | LINC01082 | 0.884078 | 5 | 0 | 5 |
| RCAN2 | MRVI1 | 0.859832 | 8 | 0 | 8 |
| RCAN2 | TBX5-AS1 | 0.852307 | 3 | 0 | 3 |
| RCAN2 | UBXN10 | 0.838299 | 3 | 0 | 3 |
| RCAN2 | TMEM100 | 0.836687 | 10 | 0 | 10 |
| RCAN2 | XKR4 | 0.835744 | 5 | 0 | 5 |
| RCAN2 | GFRA1 | 0.833087 | 7 | 0 | 7 |
| RCAN2 | NEGR1 | 0.832807 | 7 | 0 | 6 |
| RCAN2 | RGS7BP | 0.83174 | 5 | 0 | 5 |
| RCAN2 | LINC01279 | 0.827756 | 4 | 0 | 4 |
| RCAN2 | FOXF1 | 0.822997 | 13 | 0 | 13 |
| RCAN2 | WFDC1 | 0.821756 | 12 | 0 | 12 |
| RCAN2 | TCF21 | 0.820424 | 12 | 0 | 12 |
| RCAN2 | MYOC | 0.819831 | 9 | 0 | 9 |
| RCAN2 | CCL14 | 0.81738 | 3 | 0 | 3 |
| RCAN2 | SLC4A4 | 0.815655 | 6 | 0 | 6 |
| RCAN2 | PREX2 | 0.815362 | 4 | 0 | 4 |
For details and further investigation, click here
