| Full name: RAS guanyl releasing protein 2 | Alias Symbol: CALDAG-GEFI | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 10235 | HGNC ID: HGNC:9879 | Ensembl Gene: ENSG00000068831 | OMIM ID: 605577 |
| Drug and gene relationship at DGIdb | |||
RASGRP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04062 | Chemokine signaling pathway | |
| hsa04611 | Platelet activation |
Expression of RASGRP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGRP2 | 10235 | 208206_s_at | -0.3970 | 0.6471 | |
| GSE20347 | RASGRP2 | 10235 | 214367_at | 0.0705 | 0.4056 | |
| GSE23400 | RASGRP2 | 10235 | 208206_s_at | -0.2758 | 0.0001 | |
| GSE26886 | RASGRP2 | 10235 | 214368_at | 0.6386 | 0.0002 | |
| GSE29001 | RASGRP2 | 10235 | 214367_at | -0.0847 | 0.5382 | |
| GSE38129 | RASGRP2 | 10235 | 214368_at | -0.1311 | 0.1318 | |
| GSE45670 | RASGRP2 | 10235 | 208206_s_at | -0.7157 | 0.0004 | |
| GSE53622 | RASGRP2 | 10235 | 19029 | -0.8706 | 0.0000 | |
| GSE53624 | RASGRP2 | 10235 | 22506 | -1.0100 | 0.0000 | |
| GSE63941 | RASGRP2 | 10235 | 214367_at | 0.0692 | 0.6579 | |
| GSE77861 | RASGRP2 | 10235 | 214367_at | -0.0499 | 0.6459 | |
| GSE97050 | RASGRP2 | 10235 | A_33_P3209960 | -0.0857 | 0.7560 | |
| SRP064894 | RASGRP2 | 10235 | RNAseq | 0.1043 | 0.7986 | |
| SRP133303 | RASGRP2 | 10235 | RNAseq | -1.2242 | 0.0009 | |
| SRP159526 | RASGRP2 | 10235 | RNAseq | -1.5217 | 0.0004 | |
| SRP219564 | RASGRP2 | 10235 | RNAseq | -0.7671 | 0.3470 | |
| TCGA | RASGRP2 | 10235 | RNAseq | -0.9842 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RASGRP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGRP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGRP2 | 10235 | 7 | 6 | 17 | |
| GSE20123 | RASGRP2 | 10235 | 7 | 6 | 17 | |
| GSE43470 | RASGRP2 | 10235 | 1 | 3 | 39 | |
| GSE46452 | RASGRP2 | 10235 | 9 | 4 | 46 | |
| GSE47630 | RASGRP2 | 10235 | 5 | 6 | 29 | |
| GSE54993 | RASGRP2 | 10235 | 3 | 1 | 66 | |
| GSE54994 | RASGRP2 | 10235 | 6 | 5 | 42 | |
| GSE60625 | RASGRP2 | 10235 | 0 | 3 | 8 | |
| GSE74703 | RASGRP2 | 10235 | 1 | 1 | 34 | |
| GSE74704 | RASGRP2 | 10235 | 5 | 4 | 11 | |
| TCGA | RASGRP2 | 10235 | 20 | 8 | 68 |
Total number of gains: 64; Total number of losses: 47; Total Number of normals: 377.
Somatic mutations of RASGRP2:
Generating mutation plots.
Highly correlated genes for RASGRP2:
Showing top 20/864 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGRP2 | TP53I11 | 0.742458 | 3 | 0 | 3 |
| RASGRP2 | MEF2C | 0.731253 | 5 | 0 | 4 |
| RASGRP2 | CXCL12 | 0.730474 | 6 | 0 | 6 |
| RASGRP2 | HUNK | 0.72532 | 3 | 0 | 3 |
| RASGRP2 | MEF2C-AS1 | 0.722845 | 3 | 0 | 3 |
| RASGRP2 | SLC25A29 | 0.719969 | 3 | 0 | 3 |
| RASGRP2 | GDF11 | 0.717603 | 4 | 0 | 3 |
| RASGRP2 | HVCN1 | 0.714586 | 4 | 0 | 4 |
| RASGRP2 | SYNE1 | 0.710475 | 7 | 0 | 6 |
| RASGRP2 | MFGE8 | 0.705954 | 4 | 0 | 4 |
| RASGRP2 | DCHS1 | 0.697813 | 5 | 0 | 5 |
| RASGRP2 | CYP21A2 | 0.696736 | 3 | 0 | 3 |
| RASGRP2 | EIF1AY | 0.694579 | 3 | 0 | 3 |
| RASGRP2 | PDE5A | 0.693771 | 7 | 0 | 7 |
| RASGRP2 | MYOCD | 0.691119 | 5 | 0 | 5 |
| RASGRP2 | PCBP3 | 0.690562 | 3 | 0 | 3 |
| RASGRP2 | FENDRR | 0.689892 | 5 | 0 | 5 |
| RASGRP2 | NAP1L1 | 0.689397 | 3 | 0 | 3 |
| RASGRP2 | ITIH5 | 0.689325 | 6 | 0 | 6 |
| RASGRP2 | NPTXR | 0.689172 | 4 | 0 | 4 |
For details and further investigation, click here
