PLN

 

Full name: phospholamban Alias Symbol: CMD1P
Type: protein-coding gene Cytoband: 6q22.31
Entrez ID: 5350 HGNC ID: HGNC:9080 Ensembl Gene: ENSG00000198523 OMIM ID: 172405
Drug and gene relationship at DGIdb

 

PLN involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway

 

Expression of PLN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLN 5350 204939_s_at -2.5257 0.1963
GSE20347 PLN 5350 204939_s_at -1.3665 0.0259
GSE23400 PLN 5350 204939_s_at -0.9943 0.0038
GSE26886 PLN 5350 204939_s_at 1.6139 0.0361
GSE29001 PLN 5350 204939_s_at -1.5664 0.0525
GSE38129 PLN 5350 204939_s_at -1.9744 0.0022
GSE45670 PLN 5350 204939_s_at -4.2884 0.0000
GSE53622 PLN 5350 479 -3.0184 0.0000
GSE53624 PLN 5350 479 -2.7180 0.0000
GSE63941 PLN 5350 204939_s_at -0.3090 0.0078
GSE77861 PLN 5350 204939_s_at 0.3644 0.2270
GSE97050 PLN 5350 A_24_P414803 -1.7214 0.1378
SRP007169 PLN 5350 RNAseq 4.5748 0.0000
SRP064894 PLN 5350 RNAseq -0.1731 0.7184
SRP133303 PLN 5350 RNAseq -1.7653 0.0000
SRP193095 PLN 5350 RNAseq -0.3307 0.3447
SRP219564 PLN 5350 RNAseq -0.4927 0.7063
TCGA PLN 5350 RNAseq -1.0877 0.0009

Upregulated datasets: 2; Downregulated datasets: 7.  

 

Survival by PLN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLN 5350 1 4 25
GSE20123 PLN 5350 1 3 26
GSE43470 PLN 5350 4 1 38
GSE46452 PLN 5350 2 11 46
GSE47630 PLN 5350 9 4 27
GSE54993 PLN 5350 3 2 65
GSE54994 PLN 5350 8 8 37
GSE60625 PLN 5350 0 1 10
GSE74703 PLN 5350 3 1 32
GSE74704 PLN 5350 0 1 19
TCGA PLN 5350 10 20 66

Total number of gains: 41; Total number of losses: 56; Total Number of normals: 391.  

 

Somatic mutations of PLN:

 

Generating mutation plots.

 

Highly correlated genes for PLN:

 

Showing top 20/1254 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLNCNN10.87156511011
PLNUBXN100.86337303
PLNLMOD10.86110613013
PLNPRUNE20.85562713013
PLNACTG20.84960213013
PLNATP1A20.84939610010
PLNAFF30.846823303
PLNMYH110.84681312012
PLNAOC30.84674713013
PLNRBPMS20.838212808
PLNMEOX20.835537808
PLNSYNM0.83399612012
PLNANGPTL10.832433707
PLNPGR0.831198505
PLNCLEC3B0.827408303
PLNMRVI10.81715808
PLNCASQ20.81676311010
PLNSMOC20.815461707
PLNPPP1R12B0.81253412011
PLNARHGAP60.81084810010

For details and further investigation, click here