| Full name: multiple EGF like domains 8 | Alias Symbol: SBP1|FLJ22365 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 1954 | HGNC ID: HGNC:3233 | Ensembl Gene: ENSG00000105429 | OMIM ID: 604267 |
| Drug and gene relationship at DGIdb | |||
Expression of MEGF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEGF8 | 1954 | 227327_at | 0.2056 | 0.5150 | |
| GSE20347 | MEGF8 | 1954 | 214778_at | -0.1161 | 0.1288 | |
| GSE23400 | MEGF8 | 1954 | 214778_at | 0.0177 | 0.6503 | |
| GSE26886 | MEGF8 | 1954 | 227327_at | 0.1047 | 0.6198 | |
| GSE29001 | MEGF8 | 1954 | 214778_at | 0.1824 | 0.7557 | |
| GSE38129 | MEGF8 | 1954 | 214778_at | -0.1301 | 0.2762 | |
| GSE45670 | MEGF8 | 1954 | 227327_at | -0.0085 | 0.9491 | |
| GSE53622 | MEGF8 | 1954 | 53141 | -0.0160 | 0.8659 | |
| GSE53624 | MEGF8 | 1954 | 53141 | -0.1274 | 0.0607 | |
| GSE63941 | MEGF8 | 1954 | 227327_at | -0.6391 | 0.1026 | |
| GSE77861 | MEGF8 | 1954 | 227327_at | 0.0667 | 0.7427 | |
| GSE97050 | MEGF8 | 1954 | A_33_P3715177 | -0.1876 | 0.4995 | |
| SRP007169 | MEGF8 | 1954 | RNAseq | 0.0908 | 0.8417 | |
| SRP008496 | MEGF8 | 1954 | RNAseq | -0.0480 | 0.9138 | |
| SRP064894 | MEGF8 | 1954 | RNAseq | 0.6763 | 0.0058 | |
| SRP133303 | MEGF8 | 1954 | RNAseq | -0.2414 | 0.2140 | |
| SRP159526 | MEGF8 | 1954 | RNAseq | 0.6546 | 0.0383 | |
| SRP193095 | MEGF8 | 1954 | RNAseq | 0.3059 | 0.0415 | |
| SRP219564 | MEGF8 | 1954 | RNAseq | -0.3258 | 0.4928 | |
| TCGA | MEGF8 | 1954 | RNAseq | -0.2834 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MEGF8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEGF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEGF8 | 1954 | 4 | 5 | 21 | |
| GSE20123 | MEGF8 | 1954 | 4 | 4 | 22 | |
| GSE43470 | MEGF8 | 1954 | 5 | 11 | 27 | |
| GSE46452 | MEGF8 | 1954 | 47 | 1 | 11 | |
| GSE47630 | MEGF8 | 1954 | 8 | 6 | 26 | |
| GSE54993 | MEGF8 | 1954 | 17 | 4 | 49 | |
| GSE54994 | MEGF8 | 1954 | 7 | 12 | 34 | |
| GSE60625 | MEGF8 | 1954 | 9 | 0 | 2 | |
| GSE74703 | MEGF8 | 1954 | 5 | 7 | 24 | |
| GSE74704 | MEGF8 | 1954 | 4 | 2 | 14 | |
| TCGA | MEGF8 | 1954 | 13 | 16 | 67 |
Total number of gains: 123; Total number of losses: 68; Total Number of normals: 297.
Somatic mutations of MEGF8:
Generating mutation plots.
Highly correlated genes for MEGF8:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEGF8 | C7orf61 | 0.72212 | 3 | 0 | 3 |
| MEGF8 | INF2 | 0.711004 | 3 | 0 | 3 |
| MEGF8 | FAM110B | 0.701177 | 3 | 0 | 3 |
| MEGF8 | SLC34A1 | 0.700685 | 3 | 0 | 3 |
| MEGF8 | ING5 | 0.694988 | 3 | 0 | 3 |
| MEGF8 | GTF2IRD2 | 0.693581 | 3 | 0 | 3 |
| MEGF8 | CACNA1H | 0.676302 | 3 | 0 | 3 |
| MEGF8 | RNF123 | 0.675498 | 3 | 0 | 3 |
| MEGF8 | KIRREL2 | 0.67447 | 3 | 0 | 3 |
| MEGF8 | CPAMD8 | 0.673962 | 4 | 0 | 3 |
| MEGF8 | C16orf95 | 0.6737 | 3 | 0 | 3 |
| MEGF8 | CDH4 | 0.667248 | 3 | 0 | 3 |
| MEGF8 | ZFAT | 0.659403 | 3 | 0 | 3 |
| MEGF8 | SYNPO | 0.659087 | 3 | 0 | 3 |
| MEGF8 | TMEM120B | 0.656213 | 4 | 0 | 3 |
| MEGF8 | ITGB1BP2 | 0.655764 | 3 | 0 | 3 |
| MEGF8 | ZBTB48 | 0.655085 | 3 | 0 | 3 |
| MEGF8 | DOHH | 0.654689 | 4 | 0 | 3 |
| MEGF8 | IER5L | 0.651652 | 4 | 0 | 3 |
| MEGF8 | USP51 | 0.650285 | 4 | 0 | 3 |
For details and further investigation, click here
