A PHP Error was encountered

Severity: Warning

Message: exec(): Unable to fork [nohup Rscript361 /data/webapp/var/www/html/ESCCdb/application/scripts/R/proteinDomainMut.R CDK20 /data/webapp/var/www/html/ESCCdb/application/mutationPlots/>test.log 2>&1 &]

Filename: controllers/Result_pages.php

Line Number: 97

Backtrace:

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 97
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 399
Function: drawMutations

File: /data/webapp/var/www/html/ESCCdb/index.php
Line: 315
Function: require_once

Multi-Omics Database of ESCC

 

CDK20

 

Full name: cyclin dependent kinase 20 Alias Symbol: p42
Type: protein-coding gene Cytoband: 9q22.1
Entrez ID: 23552 HGNC ID: HGNC:21420 Ensembl Gene: ENSG00000156345 OMIM ID: 610076
Drug and gene relationship at DGIdb

 

Expression of CDK20:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDK20 23552 205271_s_at -0.0060 0.9911
GSE20347 CDK20 23552 205271_s_at -0.0466 0.6407
GSE23400 CDK20 23552 205271_s_at -0.1481 0.0001
GSE26886 CDK20 23552 205271_s_at 0.0343 0.8029
GSE29001 CDK20 23552 205271_s_at -0.0788 0.7548
GSE38129 CDK20 23552 205271_s_at -0.1166 0.1837
GSE45670 CDK20 23552 205271_s_at -0.0865 0.3016
GSE53622 CDK20 23552 147215 -0.1337 0.2553
GSE53624 CDK20 23552 147215 0.0382 0.6800
GSE63941 CDK20 23552 205271_s_at -0.2333 0.5627
GSE77861 CDK20 23552 205271_s_at 0.0011 0.9927
GSE97050 CDK20 23552 A_23_P20752 -0.1488 0.6127
SRP064894 CDK20 23552 RNAseq 0.0166 0.9536
SRP133303 CDK20 23552 RNAseq -0.2126 0.4799
SRP159526 CDK20 23552 RNAseq 0.6495 0.2529
SRP193095 CDK20 23552 RNAseq -0.3153 0.1207
SRP219564 CDK20 23552 RNAseq 0.1257 0.7825
TCGA CDK20 23552 RNAseq -0.3682 0.1002

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CDK20 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDK20:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDK20 23552 5 10 15
GSE20123 CDK20 23552 5 10 15
GSE43470 CDK20 23552 6 3 34
GSE46452 CDK20 23552 6 14 39
GSE47630 CDK20 23552 1 18 21
GSE54993 CDK20 23552 4 2 64
GSE54994 CDK20 23552 6 11 36
GSE60625 CDK20 23552 0 0 11
GSE74703 CDK20 23552 5 3 28
GSE74704 CDK20 23552 3 7 10
TCGA CDK20 23552 20 26 50

Total number of gains: 61; Total number of losses: 104; Total Number of normals: 323.  

 

Somatic mutations of CDK20:

 

Generating mutation plots.

 

Highly correlated genes for CDK20:

 

Showing top 20/343 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDK20MLXIPL0.71259303
CDK20TMCO20.696093303
CDK20PNCK0.695227303
CDK20CEND10.693455303
CDK20DOC2B0.690229303
CDK20GLDN0.678337303
CDK20ADAM300.674469303
CDK20PRKACG0.673206303
CDK20SLC7A100.669133404
CDK20ST8SIA50.667803303
CDK20NYX0.665862403
CDK20MAPK8IP20.663682404
CDK20SLCO5A10.66005503
CDK20PTPRJ0.659837303
CDK20TMPRSS50.659257403
CDK20SSTR30.65731303
CDK20ENTPD20.656758303
CDK20DIO30.652644303
CDK20PF40.652436404
CDK20PRUNE20.645887303

For details and further investigation, click here