| Full name: malonyl-CoA decarboxylase | Alias Symbol: MCD|hMCD | ||
| Type: protein-coding gene | Cytoband: 16q23.3 | ||
| Entrez ID: 23417 | HGNC ID: HGNC:7150 | Ensembl Gene: ENSG00000103150 | OMIM ID: 606761 |
| Drug and gene relationship at DGIdb | |||
MLYCD involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway |
Expression of MLYCD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLYCD | 23417 | 218869_at | -0.3233 | 0.5327 | |
| GSE20347 | MLYCD | 23417 | 218869_at | -0.0620 | 0.4657 | |
| GSE23400 | MLYCD | 23417 | 218869_at | -0.0945 | 0.0380 | |
| GSE26886 | MLYCD | 23417 | 218869_at | -0.1725 | 0.2515 | |
| GSE29001 | MLYCD | 23417 | 218869_at | -0.1526 | 0.3442 | |
| GSE38129 | MLYCD | 23417 | 218869_at | -0.2053 | 0.0742 | |
| GSE45670 | MLYCD | 23417 | 218869_at | 0.0527 | 0.7589 | |
| GSE53622 | MLYCD | 23417 | 103139 | -0.1505 | 0.0792 | |
| GSE53624 | MLYCD | 23417 | 103139 | -0.0115 | 0.9101 | |
| GSE63941 | MLYCD | 23417 | 218869_at | -0.1473 | 0.8018 | |
| GSE77861 | MLYCD | 23417 | 230530_at | -0.0764 | 0.6540 | |
| GSE97050 | MLYCD | 23417 | A_23_P88817 | -0.2904 | 0.3552 | |
| SRP007169 | MLYCD | 23417 | RNAseq | -0.2847 | 0.5753 | |
| SRP064894 | MLYCD | 23417 | RNAseq | -0.3528 | 0.0683 | |
| SRP133303 | MLYCD | 23417 | RNAseq | -0.4276 | 0.0234 | |
| SRP159526 | MLYCD | 23417 | RNAseq | -0.2078 | 0.4402 | |
| SRP193095 | MLYCD | 23417 | RNAseq | -0.0538 | 0.6647 | |
| SRP219564 | MLYCD | 23417 | RNAseq | -0.7979 | 0.0851 | |
| TCGA | MLYCD | 23417 | RNAseq | -0.5808 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MLYCD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLYCD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLYCD | 23417 | 5 | 4 | 21 | |
| GSE20123 | MLYCD | 23417 | 4 | 4 | 22 | |
| GSE43470 | MLYCD | 23417 | 2 | 10 | 31 | |
| GSE46452 | MLYCD | 23417 | 37 | 2 | 20 | |
| GSE47630 | MLYCD | 23417 | 11 | 9 | 20 | |
| GSE54993 | MLYCD | 23417 | 3 | 4 | 63 | |
| GSE54994 | MLYCD | 23417 | 8 | 10 | 35 | |
| GSE60625 | MLYCD | 23417 | 4 | 0 | 7 | |
| GSE74703 | MLYCD | 23417 | 2 | 7 | 27 | |
| GSE74704 | MLYCD | 23417 | 3 | 2 | 15 | |
| TCGA | MLYCD | 23417 | 25 | 18 | 53 |
Total number of gains: 104; Total number of losses: 70; Total Number of normals: 314.
Somatic mutations of MLYCD:
Generating mutation plots.
Highly correlated genes for MLYCD:
Showing top 20/442 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLYCD | RNF185 | 0.792993 | 3 | 0 | 3 |
| MLYCD | UBR2 | 0.783271 | 3 | 0 | 3 |
| MLYCD | ZSWIM5 | 0.765218 | 3 | 0 | 3 |
| MLYCD | CHADL | 0.756621 | 3 | 0 | 3 |
| MLYCD | APOLD1 | 0.753883 | 3 | 0 | 3 |
| MLYCD | DMD | 0.746516 | 3 | 0 | 3 |
| MLYCD | PTPRB | 0.735016 | 3 | 0 | 3 |
| MLYCD | LRRC55 | 0.734031 | 3 | 0 | 3 |
| MLYCD | PLAC9 | 0.723906 | 3 | 0 | 3 |
| MLYCD | RHOJ | 0.721528 | 3 | 0 | 3 |
| MLYCD | MXRA7 | 0.720463 | 3 | 0 | 3 |
| MLYCD | TSHZ1 | 0.719489 | 3 | 0 | 3 |
| MLYCD | OMD | 0.719283 | 3 | 0 | 3 |
| MLYCD | ZNF334 | 0.707613 | 3 | 0 | 3 |
| MLYCD | PNRC2 | 0.706343 | 3 | 0 | 3 |
| MLYCD | UBE4B | 0.702988 | 4 | 0 | 3 |
| MLYCD | ZNF664 | 0.701707 | 3 | 0 | 3 |
| MLYCD | HOXA2 | 0.699777 | 3 | 0 | 3 |
| MLYCD | KCTD10 | 0.693631 | 4 | 0 | 3 |
| MLYCD | NFIL3 | 0.693292 | 3 | 0 | 3 |
For details and further investigation, click here
