| Full name: ubiquitin protein ligase E3 component n-recognin 2 | Alias Symbol: bA49A4.1|dJ392M17.3|KIAA0349 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 23304 | HGNC ID: HGNC:21289 | Ensembl Gene: ENSG00000024048 | OMIM ID: 609134 |
| Drug and gene relationship at DGIdb | |||
Expression of UBR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBR2 | 23304 | 212760_at | -0.3146 | 0.3395 | |
| GSE20347 | UBR2 | 23304 | 212760_at | -0.4592 | 0.0005 | |
| GSE23400 | UBR2 | 23304 | 212760_at | -0.0089 | 0.9005 | |
| GSE26886 | UBR2 | 23304 | 212760_at | -0.7270 | 0.0167 | |
| GSE29001 | UBR2 | 23304 | 212760_at | -0.2631 | 0.1862 | |
| GSE38129 | UBR2 | 23304 | 212760_at | -0.5081 | 0.0000 | |
| GSE45670 | UBR2 | 23304 | 212760_at | -0.2028 | 0.3160 | |
| GSE53622 | UBR2 | 23304 | 24970 | -0.1595 | 0.0053 | |
| GSE53624 | UBR2 | 23304 | 119285 | 0.2675 | 0.0000 | |
| GSE63941 | UBR2 | 23304 | 212760_at | -0.7383 | 0.0627 | |
| GSE77861 | UBR2 | 23304 | 212756_s_at | -0.2597 | 0.2788 | |
| GSE97050 | UBR2 | 23304 | A_23_P362637 | -0.1154 | 0.6398 | |
| SRP007169 | UBR2 | 23304 | RNAseq | -0.0263 | 0.9419 | |
| SRP008496 | UBR2 | 23304 | RNAseq | 0.0082 | 0.9632 | |
| SRP064894 | UBR2 | 23304 | RNAseq | -0.0118 | 0.9536 | |
| SRP133303 | UBR2 | 23304 | RNAseq | 0.0350 | 0.7161 | |
| SRP159526 | UBR2 | 23304 | RNAseq | -0.1659 | 0.4028 | |
| SRP193095 | UBR2 | 23304 | RNAseq | -0.1630 | 0.0421 | |
| SRP219564 | UBR2 | 23304 | RNAseq | 0.0663 | 0.8239 | |
| TCGA | UBR2 | 23304 | RNAseq | -0.0956 | 0.0658 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBR2 | 23304 | 7 | 0 | 23 | |
| GSE20123 | UBR2 | 23304 | 7 | 0 | 23 | |
| GSE43470 | UBR2 | 23304 | 6 | 0 | 37 | |
| GSE46452 | UBR2 | 23304 | 2 | 9 | 48 | |
| GSE47630 | UBR2 | 23304 | 8 | 4 | 28 | |
| GSE54993 | UBR2 | 23304 | 3 | 2 | 65 | |
| GSE54994 | UBR2 | 23304 | 11 | 4 | 38 | |
| GSE60625 | UBR2 | 23304 | 0 | 1 | 10 | |
| GSE74703 | UBR2 | 23304 | 6 | 0 | 30 | |
| GSE74704 | UBR2 | 23304 | 3 | 0 | 17 | |
| TCGA | UBR2 | 23304 | 20 | 13 | 63 |
Total number of gains: 73; Total number of losses: 33; Total Number of normals: 382.
Somatic mutations of UBR2:
Generating mutation plots.
Highly correlated genes for UBR2:
Showing top 20/778 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBR2 | SENP8 | 0.824606 | 3 | 0 | 3 |
| UBR2 | ZRANB1 | 0.798837 | 3 | 0 | 3 |
| UBR2 | MLYCD | 0.783271 | 3 | 0 | 3 |
| UBR2 | RHBDD1 | 0.777237 | 3 | 0 | 3 |
| UBR2 | TMEM19 | 0.775586 | 3 | 0 | 3 |
| UBR2 | VPS41 | 0.758771 | 3 | 0 | 3 |
| UBR2 | FAM174A | 0.750271 | 3 | 0 | 3 |
| UBR2 | LIPT1 | 0.750094 | 3 | 0 | 3 |
| UBR2 | CETN2 | 0.748983 | 4 | 0 | 3 |
| UBR2 | ZNF585A | 0.746919 | 3 | 0 | 3 |
| UBR2 | DLD | 0.746734 | 4 | 0 | 4 |
| UBR2 | LMBRD2 | 0.745398 | 4 | 0 | 3 |
| UBR2 | BAG3 | 0.743985 | 3 | 0 | 3 |
| UBR2 | FAM122A | 0.741823 | 3 | 0 | 3 |
| UBR2 | CLIP4 | 0.735961 | 3 | 0 | 3 |
| UBR2 | MRPS36 | 0.733568 | 3 | 0 | 3 |
| UBR2 | METTL14 | 0.731221 | 3 | 0 | 3 |
| UBR2 | ZNF248 | 0.730125 | 3 | 0 | 3 |
| UBR2 | NDUFA12 | 0.727638 | 3 | 0 | 3 |
| UBR2 | RRAGA | 0.725 | 5 | 0 | 4 |
For details and further investigation, click here
