DMD

 

Full name: dystrophin Alias Symbol: BMD|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272
Type: protein-coding gene Cytoband: Xp21.2-p21.1
Entrez ID: 1756 HGNC ID: HGNC:2928 Ensembl Gene: ENSG00000198947 OMIM ID: 300377
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DMD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DMD 1756 203881_s_at -1.8676 0.1535
GSE20347 DMD 1756 203881_s_at -0.7864 0.1302
GSE23400 DMD 1756 203881_s_at -0.6455 0.0146
GSE26886 DMD 1756 203881_s_at -0.2420 0.7438
GSE29001 DMD 1756 203881_s_at -0.9808 0.1347
GSE38129 DMD 1756 203881_s_at -1.4575 0.0078
GSE45670 DMD 1756 203881_s_at -2.0270 0.0000
GSE53622 DMD 1756 9045 -1.4842 0.0000
GSE53624 DMD 1756 9045 -0.8790 0.0000
GSE63941 DMD 1756 203881_s_at -1.6907 0.2129
GSE77861 DMD 1756 208086_s_at 0.0089 0.9319
GSE97050 DMD 1756 A_33_P3284763 -1.4700 0.0867
SRP007169 DMD 1756 RNAseq 1.2942 0.1122
SRP064894 DMD 1756 RNAseq -0.7101 0.0650
SRP133303 DMD 1756 RNAseq -0.5365 0.3239
SRP159526 DMD 1756 RNAseq 0.3089 0.6277
SRP193095 DMD 1756 RNAseq 0.0629 0.8283
SRP219564 DMD 1756 RNAseq -0.9480 0.2849
TCGA DMD 1756 RNAseq -0.8617 0.0000

Upregulated datasets: 0; Downregulated datasets: 3.  


 

Survival by DMD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of DMD:

 

No record found for this gene.


 

Somatic mutations of DMD:

 

Generating mutation plots.

 

Highly correlated genes for DMD:

 

Showing top 20/936 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DMDFIBIN0.839521303
DMDEPDR10.788012303
DMDC1QTNF70.782138505
DMDADAMTS9-AS20.779514404
DMDWWTR10.775226707
DMDCREB30.772061303
DMDPDE5A0.769772908
DMDNKAPL0.768686303
DMDADARB10.768473707
DMDSORCS10.7662404
DMDRNF2140.762679303
DMDHSPB70.761099808
DMDCHRDL10.7602381009
DMDPLAC90.760236404
DMDRNF1500.755717606
DMDPGR0.751305505
DMDCELF20.75059711011
DMDCACNA1C0.749124404
DMDPYGM0.747344808
DMDMLYCD0.746516303

For details and further investigation, click here