| Full name: metabolism of cobalamin associated C | Alias Symbol: DKFZP564I122|cblC | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 25974 | HGNC ID: HGNC:24525 | Ensembl Gene: ENSG00000132763 | OMIM ID: 609831 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MMACHC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMACHC | 25974 | 211774_s_at | 0.6053 | 0.3147 | |
| GSE20347 | MMACHC | 25974 | 211774_s_at | 0.3192 | 0.0019 | |
| GSE23400 | MMACHC | 25974 | 211774_s_at | 0.0277 | 0.3859 | |
| GSE26886 | MMACHC | 25974 | 211774_s_at | 0.4458 | 0.0508 | |
| GSE29001 | MMACHC | 25974 | 211774_s_at | 0.3946 | 0.0476 | |
| GSE38129 | MMACHC | 25974 | 211774_s_at | 0.2335 | 0.0006 | |
| GSE45670 | MMACHC | 25974 | 211774_s_at | 0.3889 | 0.0278 | |
| GSE53622 | MMACHC | 25974 | 75533 | 0.4674 | 0.0000 | |
| GSE53624 | MMACHC | 25974 | 75533 | 0.5556 | 0.0000 | |
| GSE63941 | MMACHC | 25974 | 211774_s_at | 0.7405 | 0.0366 | |
| GSE77861 | MMACHC | 25974 | 211774_s_at | -0.0423 | 0.7751 | |
| GSE97050 | MMACHC | 25974 | A_33_P3390643 | 0.6134 | 0.1049 | |
| SRP007169 | MMACHC | 25974 | RNAseq | 0.4560 | 0.2896 | |
| SRP008496 | MMACHC | 25974 | RNAseq | 0.3413 | 0.3628 | |
| SRP064894 | MMACHC | 25974 | RNAseq | 0.0216 | 0.9247 | |
| SRP133303 | MMACHC | 25974 | RNAseq | -0.0717 | 0.5777 | |
| SRP159526 | MMACHC | 25974 | RNAseq | 0.9303 | 0.0822 | |
| SRP193095 | MMACHC | 25974 | RNAseq | -0.0296 | 0.8357 | |
| SRP219564 | MMACHC | 25974 | RNAseq | 0.7068 | 0.0614 | |
| TCGA | MMACHC | 25974 | RNAseq | 0.0465 | 0.6704 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MMACHC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMACHC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMACHC | 25974 | 4 | 3 | 23 | |
| GSE20123 | MMACHC | 25974 | 4 | 2 | 24 | |
| GSE43470 | MMACHC | 25974 | 7 | 2 | 34 | |
| GSE46452 | MMACHC | 25974 | 2 | 1 | 56 | |
| GSE47630 | MMACHC | 25974 | 9 | 3 | 28 | |
| GSE54993 | MMACHC | 25974 | 0 | 1 | 69 | |
| GSE54994 | MMACHC | 25974 | 12 | 2 | 39 | |
| GSE60625 | MMACHC | 25974 | 0 | 0 | 11 | |
| GSE74703 | MMACHC | 25974 | 6 | 1 | 29 | |
| GSE74704 | MMACHC | 25974 | 2 | 0 | 18 | |
| TCGA | MMACHC | 25974 | 11 | 16 | 69 |
Total number of gains: 57; Total number of losses: 31; Total Number of normals: 400.
Somatic mutations of MMACHC:
Generating mutation plots.
Highly correlated genes for MMACHC:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMACHC | JTB | 0.773985 | 3 | 0 | 3 |
| MMACHC | MUC16 | 0.762876 | 3 | 0 | 3 |
| MMACHC | FN3KRP | 0.752614 | 3 | 0 | 3 |
| MMACHC | NKRF | 0.74854 | 4 | 0 | 4 |
| MMACHC | ZBED4 | 0.743777 | 3 | 0 | 3 |
| MMACHC | SNRPD3 | 0.736991 | 3 | 0 | 3 |
| MMACHC | TDRD5 | 0.724394 | 3 | 0 | 3 |
| MMACHC | TMEM44 | 0.724268 | 4 | 0 | 3 |
| MMACHC | DHX33 | 0.708205 | 3 | 0 | 3 |
| MMACHC | RNASET2 | 0.706482 | 3 | 0 | 3 |
| MMACHC | PSMG3 | 0.704951 | 3 | 0 | 3 |
| MMACHC | CCT8 | 0.70485 | 4 | 0 | 4 |
| MMACHC | KLHDC3 | 0.703773 | 3 | 0 | 3 |
| MMACHC | LINC01305 | 0.70374 | 3 | 0 | 3 |
| MMACHC | CDKN2C | 0.701101 | 3 | 0 | 3 |
| MMACHC | RNF7 | 0.700243 | 4 | 0 | 4 |
| MMACHC | ZMPSTE24 | 0.693435 | 3 | 0 | 3 |
| MMACHC | CENPBD1 | 0.690327 | 4 | 0 | 4 |
| MMACHC | SRSF10 | 0.689245 | 5 | 0 | 4 |
| MMACHC | LINC01410 | 0.689183 | 3 | 0 | 3 |
For details and further investigation, click here
