| Full name: zinc metallopeptidase STE24 | Alias Symbol: FACE-1|Ste24p|STE24|HGPS|PRO1 | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 10269 | HGNC ID: HGNC:12877 | Ensembl Gene: ENSG00000084073 | OMIM ID: 606480 |
| Drug and gene relationship at DGIdb | |||
Expression of ZMPSTE24:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZMPSTE24 | 10269 | 202939_at | 0.0836 | 0.8911 | |
| GSE20347 | ZMPSTE24 | 10269 | 202939_at | -0.2737 | 0.0354 | |
| GSE23400 | ZMPSTE24 | 10269 | 202939_at | 0.2038 | 0.0265 | |
| GSE26886 | ZMPSTE24 | 10269 | 202939_at | -0.4388 | 0.0119 | |
| GSE29001 | ZMPSTE24 | 10269 | 202939_at | -0.0801 | 0.7444 | |
| GSE38129 | ZMPSTE24 | 10269 | 202939_at | -0.1507 | 0.1837 | |
| GSE45670 | ZMPSTE24 | 10269 | 202939_at | 0.2151 | 0.0834 | |
| GSE53622 | ZMPSTE24 | 10269 | 21853 | -0.0806 | 0.1786 | |
| GSE53624 | ZMPSTE24 | 10269 | 21853 | 0.1835 | 0.0015 | |
| GSE63941 | ZMPSTE24 | 10269 | 202939_at | -1.1031 | 0.0255 | |
| GSE77861 | ZMPSTE24 | 10269 | 202939_at | -0.0245 | 0.9467 | |
| GSE97050 | ZMPSTE24 | 10269 | A_23_P137427 | 0.0757 | 0.8190 | |
| SRP007169 | ZMPSTE24 | 10269 | RNAseq | -0.5433 | 0.3502 | |
| SRP008496 | ZMPSTE24 | 10269 | RNAseq | -0.3906 | 0.2139 | |
| SRP064894 | ZMPSTE24 | 10269 | RNAseq | 0.3444 | 0.0187 | |
| SRP133303 | ZMPSTE24 | 10269 | RNAseq | 0.6459 | 0.0000 | |
| SRP193095 | ZMPSTE24 | 10269 | RNAseq | 0.0748 | 0.4953 | |
| SRP219564 | ZMPSTE24 | 10269 | RNAseq | 0.5326 | 0.2244 | |
| TCGA | ZMPSTE24 | 10269 | RNAseq | 0.0386 | 0.4788 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ZMPSTE24 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZMPSTE24:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZMPSTE24 | 10269 | 3 | 4 | 23 | |
| GSE20123 | ZMPSTE24 | 10269 | 2 | 3 | 25 | |
| GSE43470 | ZMPSTE24 | 10269 | 7 | 2 | 34 | |
| GSE46452 | ZMPSTE24 | 10269 | 4 | 1 | 54 | |
| GSE47630 | ZMPSTE24 | 10269 | 9 | 2 | 29 | |
| GSE54993 | ZMPSTE24 | 10269 | 0 | 1 | 69 | |
| GSE54994 | ZMPSTE24 | 10269 | 13 | 2 | 38 | |
| GSE60625 | ZMPSTE24 | 10269 | 0 | 0 | 11 | |
| GSE74703 | ZMPSTE24 | 10269 | 6 | 1 | 29 | |
| GSE74704 | ZMPSTE24 | 10269 | 1 | 0 | 19 | |
| TCGA | ZMPSTE24 | 10269 | 16 | 16 | 64 |
Total number of gains: 61; Total number of losses: 32; Total Number of normals: 395.
Somatic mutations of ZMPSTE24:
Generating mutation plots.
Highly correlated genes for ZMPSTE24:
Showing top 20/652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZMPSTE24 | FNTA | 0.790974 | 3 | 0 | 3 |
| ZMPSTE24 | CETN3 | 0.775351 | 3 | 0 | 3 |
| ZMPSTE24 | CDC73 | 0.773472 | 3 | 0 | 3 |
| ZMPSTE24 | VPS29 | 0.767957 | 3 | 0 | 3 |
| ZMPSTE24 | LUC7L2 | 0.766137 | 3 | 0 | 3 |
| ZMPSTE24 | PRMT6 | 0.765719 | 3 | 0 | 3 |
| ZMPSTE24 | ZMAT3 | 0.762924 | 3 | 0 | 3 |
| ZMPSTE24 | BLOC1S2 | 0.762031 | 3 | 0 | 3 |
| ZMPSTE24 | USP32 | 0.759402 | 3 | 0 | 3 |
| ZMPSTE24 | TCHP | 0.759001 | 3 | 0 | 3 |
| ZMPSTE24 | NEK7 | 0.758238 | 3 | 0 | 3 |
| ZMPSTE24 | LSM1 | 0.754121 | 3 | 0 | 3 |
| ZMPSTE24 | MRPS18A | 0.752522 | 3 | 0 | 3 |
| ZMPSTE24 | C1orf122 | 0.75102 | 7 | 0 | 7 |
| ZMPSTE24 | PLEKHM3 | 0.748762 | 3 | 0 | 3 |
| ZMPSTE24 | MYSM1 | 0.745216 | 4 | 0 | 4 |
| ZMPSTE24 | CYB5D1 | 0.740678 | 3 | 0 | 3 |
| ZMPSTE24 | PANK1 | 0.739909 | 3 | 0 | 3 |
| ZMPSTE24 | TPRG1L | 0.739814 | 3 | 0 | 3 |
| ZMPSTE24 | PTEN | 0.739555 | 3 | 0 | 3 |
For details and further investigation, click here
