| Full name: mucin 16, cell surface associated | Alias Symbol: CA125|FLJ14303 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 94025 | HGNC ID: HGNC:15582 | Ensembl Gene: ENSG00000181143 | OMIM ID: 606154 |
| Drug and gene relationship at DGIdb | |||
Expression of MUC16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUC16 | 94025 | 220196_at | 0.6426 | 0.6789 | |
| GSE20347 | MUC16 | 94025 | 220196_at | 0.3217 | 0.0219 | |
| GSE23400 | MUC16 | 94025 | 220196_at | 0.0496 | 0.4331 | |
| GSE26886 | MUC16 | 94025 | 220196_at | 0.7675 | 0.0261 | |
| GSE29001 | MUC16 | 94025 | 220196_at | 0.3366 | 0.1542 | |
| GSE38129 | MUC16 | 94025 | 220196_at | 0.2538 | 0.0240 | |
| GSE45670 | MUC16 | 94025 | 220196_at | 0.2052 | 0.5833 | |
| GSE53622 | MUC16 | 94025 | 102656 | 0.2232 | 0.6762 | |
| GSE53624 | MUC16 | 94025 | 102656 | 0.1300 | 0.6915 | |
| GSE63941 | MUC16 | 94025 | 220196_at | 1.0243 | 0.4040 | |
| GSE77861 | MUC16 | 94025 | 220196_at | -0.0545 | 0.6010 | |
| GSE97050 | MUC16 | 94025 | A_33_P3313110 | 1.5490 | 0.1058 | |
| SRP133303 | MUC16 | 94025 | RNAseq | 0.2809 | 0.7680 | |
| SRP219564 | MUC16 | 94025 | RNAseq | 4.0646 | 0.0638 | |
| TCGA | MUC16 | 94025 | RNAseq | 2.1428 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MUC16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MUC16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUC16 | 94025 | 4 | 3 | 23 | |
| GSE20123 | MUC16 | 94025 | 3 | 2 | 25 | |
| GSE43470 | MUC16 | 94025 | 3 | 5 | 35 | |
| GSE46452 | MUC16 | 94025 | 47 | 1 | 11 | |
| GSE47630 | MUC16 | 94025 | 5 | 7 | 28 | |
| GSE54993 | MUC16 | 94025 | 16 | 2 | 52 | |
| GSE54994 | MUC16 | 94025 | 6 | 14 | 33 | |
| GSE60625 | MUC16 | 94025 | 9 | 0 | 2 | |
| GSE74703 | MUC16 | 94025 | 3 | 4 | 29 | |
| GSE74704 | MUC16 | 94025 | 0 | 2 | 18 | |
| TCGA | MUC16 | 94025 | 10 | 19 | 67 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of MUC16:
Generating mutation plots.
Highly correlated genes for MUC16:
Showing top 20/98 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUC16 | NOL4 | 0.76637 | 3 | 0 | 3 |
| MUC16 | MMACHC | 0.762876 | 3 | 0 | 3 |
| MUC16 | SLC45A3 | 0.721745 | 3 | 0 | 3 |
| MUC16 | SPC24 | 0.71992 | 3 | 0 | 3 |
| MUC16 | LTA | 0.712604 | 3 | 0 | 3 |
| MUC16 | RPAP3 | 0.686047 | 4 | 0 | 4 |
| MUC16 | ZNF616 | 0.683801 | 3 | 0 | 3 |
| MUC16 | FAM161A | 0.679503 | 3 | 0 | 3 |
| MUC16 | ZNF618 | 0.676916 | 3 | 0 | 3 |
| MUC16 | STAG1 | 0.662348 | 3 | 0 | 3 |
| MUC16 | SPAG5 | 0.659002 | 4 | 0 | 3 |
| MUC16 | SPICE1 | 0.652852 | 4 | 0 | 3 |
| MUC16 | WDR25 | 0.64585 | 3 | 0 | 3 |
| MUC16 | TRIM27 | 0.638986 | 4 | 0 | 4 |
| MUC16 | MND1 | 0.634615 | 4 | 0 | 3 |
| MUC16 | LIG1 | 0.634362 | 3 | 0 | 3 |
| MUC16 | RNFT2 | 0.634116 | 4 | 0 | 3 |
| MUC16 | POLA1 | 0.633431 | 4 | 0 | 3 |
| MUC16 | CCDC24 | 0.631281 | 4 | 0 | 3 |
| MUC16 | SMG9 | 0.630072 | 3 | 0 | 3 |
For details and further investigation, click here
