PSMG3

 

Full name: proteasome assembly chaperone 3 Alias Symbol: MGC10911|PAC3
Type: protein-coding gene Cytoband: 7p22.3
Entrez ID: 84262 HGNC ID: HGNC:22420 Ensembl Gene: ENSG00000157778 OMIM ID: 617528
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PSMG3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PSMG3 84262 223363_at 0.5269 0.1463
GSE26886 PSMG3 84262 223363_at 1.2713 0.0000
GSE45670 PSMG3 84262 223363_at 0.6092 0.0001
GSE53622 PSMG3 84262 35838 0.6811 0.0000
GSE53624 PSMG3 84262 35838 0.7360 0.0000
GSE63941 PSMG3 84262 223363_at 0.2192 0.5423
GSE77861 PSMG3 84262 223363_at 0.6957 0.0004
GSE97050 PSMG3 84262 A_24_P21044 0.6127 0.3368
SRP007169 PSMG3 84262 RNAseq 1.0057 0.0678
SRP008496 PSMG3 84262 RNAseq 1.3133 0.0075
SRP064894 PSMG3 84262 RNAseq 1.1343 0.0013
SRP133303 PSMG3 84262 RNAseq 0.7736 0.0003
SRP159526 PSMG3 84262 RNAseq 0.6602 0.0138
SRP193095 PSMG3 84262 RNAseq 0.4095 0.0020
SRP219564 PSMG3 84262 RNAseq 1.0959 0.0226
TCGA PSMG3 84262 RNAseq 0.4406 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by PSMG3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PSMG3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PSMG3 84262 14 0 16
GSE20123 PSMG3 84262 14 0 16
GSE43470 PSMG3 84262 6 2 35
GSE46452 PSMG3 84262 13 1 45
GSE47630 PSMG3 84262 10 1 29
GSE54993 PSMG3 84262 0 7 63
GSE54994 PSMG3 84262 19 2 32
GSE60625 PSMG3 84262 0 0 11
GSE74703 PSMG3 84262 6 1 29
GSE74704 PSMG3 84262 9 0 11
TCGA PSMG3 84262 57 5 34

Total number of gains: 148; Total number of losses: 19; Total Number of normals: 321.  

 

Somatic mutations of PSMG3:

 

Generating mutation plots.

 

Highly correlated genes for PSMG3:

 

Showing top 20/2170 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PSMG3SEMA3C0.820864303
PSMG3TRAF70.813567505
PSMG3TRADD0.812954303
PSMG3ANKRD110.806522303
PSMG3DNAJC90.804371303
PSMG3DSCC10.802081404
PSMG3EME10.791927505
PSMG3BIRC50.791087606
PSMG3SNRPG0.790378606
PSMG3TUBA1B0.786404404
PSMG3U2SURP0.784533505
PSMG3BRMS10.783489606
PSMG3GINS40.781583303
PSMG3MRPL470.78091707
PSMG3CLSPN0.779243606
PSMG3GNB50.778835303
PSMG3TUBA1C0.777111303
PSMG3PMS20.776529303
PSMG3CCDC860.774746505
PSMG3CLCN70.773987404

For details and further investigation, click here