| Full name: cyclin dependent kinase inhibitor 2C | Alias Symbol: INK4C|p18 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 1031 | HGNC ID: HGNC:1789 | Ensembl Gene: ENSG00000123080 | OMIM ID: 603369 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CDKN2C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of CDKN2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKN2C | 1031 | 204159_at | 0.3956 | 0.5910 | |
| GSE20347 | CDKN2C | 1031 | 204159_at | 0.0475 | 0.9182 | |
| GSE23400 | CDKN2C | 1031 | 211792_s_at | -0.0563 | 0.2560 | |
| GSE26886 | CDKN2C | 1031 | 204159_at | -0.7262 | 0.0297 | |
| GSE29001 | CDKN2C | 1031 | 204159_at | 0.6635 | 0.1465 | |
| GSE38129 | CDKN2C | 1031 | 204159_at | -0.2763 | 0.3151 | |
| GSE45670 | CDKN2C | 1031 | 204159_at | -0.2981 | 0.3721 | |
| GSE53622 | CDKN2C | 1031 | 54226 | -0.1622 | 0.3121 | |
| GSE53624 | CDKN2C | 1031 | 54226 | -0.0608 | 0.6837 | |
| GSE63941 | CDKN2C | 1031 | 204159_at | -0.2888 | 0.8455 | |
| GSE77861 | CDKN2C | 1031 | 211792_s_at | -0.3086 | 0.0611 | |
| GSE97050 | CDKN2C | 1031 | A_33_P3292540 | 0.0916 | 0.8138 | |
| SRP007169 | CDKN2C | 1031 | RNAseq | -1.9215 | 0.0004 | |
| SRP008496 | CDKN2C | 1031 | RNAseq | -1.5227 | 0.0002 | |
| SRP064894 | CDKN2C | 1031 | RNAseq | -0.4374 | 0.1157 | |
| SRP133303 | CDKN2C | 1031 | RNAseq | 0.1840 | 0.5359 | |
| SRP159526 | CDKN2C | 1031 | RNAseq | 0.6264 | 0.2843 | |
| SRP193095 | CDKN2C | 1031 | RNAseq | -0.1028 | 0.6278 | |
| SRP219564 | CDKN2C | 1031 | RNAseq | 0.7523 | 0.2340 | |
| TCGA | CDKN2C | 1031 | RNAseq | 0.3684 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CDKN2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKN2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKN2C | 1031 | 3 | 4 | 23 | |
| GSE20123 | CDKN2C | 1031 | 3 | 3 | 24 | |
| GSE43470 | CDKN2C | 1031 | 5 | 4 | 34 | |
| GSE46452 | CDKN2C | 1031 | 2 | 1 | 56 | |
| GSE47630 | CDKN2C | 1031 | 8 | 4 | 28 | |
| GSE54993 | CDKN2C | 1031 | 0 | 1 | 69 | |
| GSE54994 | CDKN2C | 1031 | 11 | 2 | 40 | |
| GSE60625 | CDKN2C | 1031 | 0 | 0 | 11 | |
| GSE74703 | CDKN2C | 1031 | 4 | 2 | 30 | |
| GSE74704 | CDKN2C | 1031 | 2 | 0 | 18 | |
| TCGA | CDKN2C | 1031 | 9 | 20 | 67 |
Total number of gains: 47; Total number of losses: 41; Total Number of normals: 400.
Somatic mutations of CDKN2C:
Generating mutation plots.
Highly correlated genes for CDKN2C:
Showing top 20/211 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKN2C | FOXP4 | 0.802698 | 3 | 0 | 3 |
| CDKN2C | RBM4B | 0.788182 | 3 | 0 | 3 |
| CDKN2C | POLR3C | 0.786338 | 3 | 0 | 3 |
| CDKN2C | ZNF445 | 0.757012 | 3 | 0 | 3 |
| CDKN2C | MKRN2 | 0.745876 | 3 | 0 | 3 |
| CDKN2C | ICA1L | 0.737009 | 3 | 0 | 3 |
| CDKN2C | PRKCH | 0.733229 | 3 | 0 | 3 |
| CDKN2C | MPP5 | 0.732642 | 4 | 0 | 4 |
| CDKN2C | RUFY1 | 0.727914 | 3 | 0 | 3 |
| CDKN2C | SPRYD4 | 0.727553 | 3 | 0 | 3 |
| CDKN2C | GLRX5 | 0.718645 | 3 | 0 | 3 |
| CDKN2C | RNFT2 | 0.718248 | 3 | 0 | 3 |
| CDKN2C | ARID1A | 0.717619 | 3 | 0 | 3 |
| CDKN2C | CHAF1B | 0.71404 | 3 | 0 | 3 |
| CDKN2C | CCT8 | 0.712773 | 3 | 0 | 3 |
| CDKN2C | TMEM129 | 0.71209 | 3 | 0 | 3 |
| CDKN2C | TSEN34 | 0.709912 | 4 | 0 | 4 |
| CDKN2C | WDR26 | 0.709806 | 3 | 0 | 3 |
| CDKN2C | NAT1 | 0.708171 | 3 | 0 | 3 |
| CDKN2C | ZNF436 | 0.702961 | 3 | 0 | 3 |
For details and further investigation, click here
