| Full name: mitochondrial ribosomal protein L45 | Alias Symbol: MGC11321 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 84311 | HGNC ID: HGNC:16651 | Ensembl Gene: ENSG00000278845 | OMIM ID: 611850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL45:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL45 | 84311 | 224479_s_at | -0.0549 | 0.9107 | |
| GSE26886 | MRPL45 | 84311 | 224479_s_at | 0.2719 | 0.1597 | |
| GSE45670 | MRPL45 | 84311 | 224479_s_at | 0.0350 | 0.8984 | |
| GSE53622 | MRPL45 | 84311 | 133853 | 0.3689 | 0.0000 | |
| GSE53624 | MRPL45 | 84311 | 31739 | 0.1561 | 0.0036 | |
| GSE63941 | MRPL45 | 84311 | 224479_s_at | 0.6621 | 0.1097 | |
| GSE77861 | MRPL45 | 84311 | 224479_s_at | 0.3052 | 0.0522 | |
| GSE97050 | MRPL45 | 84311 | A_32_P9575 | 0.0308 | 0.9157 | |
| SRP007169 | MRPL45 | 84311 | RNAseq | 0.0631 | 0.8552 | |
| SRP008496 | MRPL45 | 84311 | RNAseq | -0.2140 | 0.3694 | |
| SRP064894 | MRPL45 | 84311 | RNAseq | 0.0346 | 0.8398 | |
| SRP133303 | MRPL45 | 84311 | RNAseq | 0.0753 | 0.5952 | |
| SRP159526 | MRPL45 | 84311 | RNAseq | -0.0433 | 0.8734 | |
| SRP193095 | MRPL45 | 84311 | RNAseq | -0.2013 | 0.0782 | |
| SRP219564 | MRPL45 | 84311 | RNAseq | -0.3085 | 0.2983 | |
| TCGA | MRPL45 | 84311 | RNAseq | 0.0034 | 0.9469 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL45 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL45:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL45 | 84311 | 6 | 1 | 23 | |
| GSE20123 | MRPL45 | 84311 | 6 | 1 | 23 | |
| GSE43470 | MRPL45 | 84311 | 2 | 0 | 41 | |
| GSE46452 | MRPL45 | 84311 | 34 | 0 | 25 | |
| GSE47630 | MRPL45 | 84311 | 8 | 1 | 31 | |
| GSE54993 | MRPL45 | 84311 | 3 | 3 | 64 | |
| GSE54994 | MRPL45 | 84311 | 8 | 5 | 40 | |
| GSE60625 | MRPL45 | 84311 | 4 | 0 | 7 | |
| GSE74703 | MRPL45 | 84311 | 1 | 0 | 35 | |
| GSE74704 | MRPL45 | 84311 | 3 | 1 | 16 | |
| TCGA | MRPL45 | 84311 | 19 | 9 | 68 |
Total number of gains: 94; Total number of losses: 21; Total Number of normals: 373.
Somatic mutations of MRPL45:
Generating mutation plots.
Highly correlated genes for MRPL45:
Showing top 20/442 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL45 | PTCD2 | 0.799863 | 3 | 0 | 3 |
| MRPL45 | SPTSSA | 0.758311 | 3 | 0 | 3 |
| MRPL45 | TMEM135 | 0.752693 | 3 | 0 | 3 |
| MRPL45 | PSMD7 | 0.747963 | 4 | 0 | 3 |
| MRPL45 | PLAGL2 | 0.745737 | 3 | 0 | 3 |
| MRPL45 | ZFHX3 | 0.737046 | 3 | 0 | 3 |
| MRPL45 | TERF2IP | 0.73597 | 3 | 0 | 3 |
| MRPL45 | UBR1 | 0.730678 | 4 | 0 | 4 |
| MRPL45 | DPH5 | 0.722388 | 4 | 0 | 3 |
| MRPL45 | PRKRA | 0.719787 | 3 | 0 | 3 |
| MRPL45 | SPRED1 | 0.715509 | 4 | 0 | 4 |
| MRPL45 | RPL19 | 0.713811 | 4 | 0 | 4 |
| MRPL45 | JMY | 0.713581 | 4 | 0 | 4 |
| MRPL45 | TWISTNB | 0.710713 | 4 | 0 | 3 |
| MRPL45 | ZNF343 | 0.71034 | 3 | 0 | 3 |
| MRPL45 | SPAG9 | 0.70838 | 4 | 0 | 3 |
| MRPL45 | SNAP23 | 0.707802 | 3 | 0 | 3 |
| MRPL45 | HSF2 | 0.7037 | 3 | 0 | 3 |
| MRPL45 | NDUFV1 | 0.703137 | 4 | 0 | 3 |
| MRPL45 | ELP3 | 0.700995 | 4 | 0 | 3 |
For details and further investigation, click here
