| Full name: protein activator of interferon induced protein kinase EIF2AK2 | Alias Symbol: PACT|RAX|HSD14|DYT16 | ||
| Type: protein-coding gene | Cytoband: 2q31.2 | ||
| Entrez ID: 8575 | HGNC ID: HGNC:9438 | Ensembl Gene: ENSG00000180228 | OMIM ID: 603424 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRKRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKRA | 8575 | 209139_s_at | 0.2318 | 0.5681 | |
| GSE20347 | PRKRA | 8575 | 209139_s_at | 0.2921 | 0.2175 | |
| GSE23400 | PRKRA | 8575 | 209139_s_at | 0.3213 | 0.0012 | |
| GSE26886 | PRKRA | 8575 | 209139_s_at | 0.3752 | 0.1088 | |
| GSE29001 | PRKRA | 8575 | 209139_s_at | 0.2251 | 0.2530 | |
| GSE38129 | PRKRA | 8575 | 209139_s_at | 0.4104 | 0.0090 | |
| GSE45670 | PRKRA | 8575 | 209139_s_at | -0.1724 | 0.3619 | |
| GSE63941 | PRKRA | 8575 | 209139_s_at | 0.4310 | 0.3924 | |
| GSE77861 | PRKRA | 8575 | 209139_s_at | 0.1959 | 0.3186 | |
| GSE97050 | PRKRA | 8575 | A_23_P91019 | -0.2474 | 0.3482 | |
| SRP007169 | PRKRA | 8575 | RNAseq | 0.2358 | 0.5307 | |
| SRP008496 | PRKRA | 8575 | RNAseq | 0.2730 | 0.2764 | |
| SRP064894 | PRKRA | 8575 | RNAseq | -0.0053 | 0.9678 | |
| SRP133303 | PRKRA | 8575 | RNAseq | 0.3101 | 0.0383 | |
| SRP159526 | PRKRA | 8575 | RNAseq | 0.0793 | 0.6232 | |
| SRP193095 | PRKRA | 8575 | RNAseq | 0.0925 | 0.5748 | |
| SRP219564 | PRKRA | 8575 | RNAseq | -0.4147 | 0.2186 | |
| TCGA | PRKRA | 8575 | RNAseq | 0.0244 | 0.6085 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRKRA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PRKRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKRA | 8575 | 7 | 0 | 23 | |
| GSE20123 | PRKRA | 8575 | 7 | 0 | 23 | |
| GSE43470 | PRKRA | 8575 | 5 | 1 | 37 | |
| GSE46452 | PRKRA | 8575 | 1 | 4 | 54 | |
| GSE47630 | PRKRA | 8575 | 4 | 4 | 32 | |
| GSE54993 | PRKRA | 8575 | 0 | 5 | 65 | |
| GSE54994 | PRKRA | 8575 | 11 | 4 | 38 | |
| GSE60625 | PRKRA | 8575 | 0 | 3 | 8 | |
| GSE74703 | PRKRA | 8575 | 4 | 1 | 31 | |
| GSE74704 | PRKRA | 8575 | 4 | 0 | 16 | |
| TCGA | PRKRA | 8575 | 28 | 6 | 62 |
Total number of gains: 71; Total number of losses: 28; Total Number of normals: 389.
Somatic mutations of PRKRA:
Generating mutation plots.
Highly correlated genes for PRKRA:
Showing top 20/479 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKRA | STOM | 0.748449 | 3 | 0 | 3 |
| PRKRA | SNAPIN | 0.738008 | 3 | 0 | 3 |
| PRKRA | SESTD1 | 0.729719 | 3 | 0 | 3 |
| PRKRA | SLC25A44 | 0.725483 | 3 | 0 | 3 |
| PRKRA | AKAP8 | 0.724316 | 3 | 0 | 3 |
| PRKRA | NSRP1 | 0.723146 | 3 | 0 | 3 |
| PRKRA | MRPL45 | 0.719787 | 3 | 0 | 3 |
| PRKRA | BOD1 | 0.717926 | 3 | 0 | 3 |
| PRKRA | CPT1A | 0.713548 | 3 | 0 | 3 |
| PRKRA | METAP1D | 0.711487 | 3 | 0 | 3 |
| PRKRA | UCN | 0.709523 | 3 | 0 | 3 |
| PRKRA | TRMT11 | 0.706916 | 4 | 0 | 4 |
| PRKRA | PITPNB | 0.701151 | 4 | 0 | 3 |
| PRKRA | C8orf76 | 0.698493 | 3 | 0 | 3 |
| PRKRA | SRSF7 | 0.693174 | 5 | 0 | 4 |
| PRKRA | TFAM | 0.68703 | 3 | 0 | 3 |
| PRKRA | PCGF6 | 0.685715 | 4 | 0 | 4 |
| PRKRA | MRPS5 | 0.680261 | 3 | 0 | 3 |
| PRKRA | ARV1 | 0.677303 | 4 | 0 | 4 |
| PRKRA | LZTS2 | 0.677151 | 3 | 0 | 3 |
For details and further investigation, click here
