| Full name: sortilin related VPS10 domain containing receptor 3 | Alias Symbol: KIAA1059|SORCS | ||
| Type: protein-coding gene | Cytoband: 10q25.1 | ||
| Entrez ID: 22986 | HGNC ID: HGNC:16699 | Ensembl Gene: ENSG00000156395 | OMIM ID: 606285 |
| Drug and gene relationship at DGIdb | |||
Expression of SORCS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SORCS3 | 22986 | 215522_at | 0.0875 | 0.6806 | |
| GSE20347 | SORCS3 | 22986 | 215522_at | 0.0362 | 0.5703 | |
| GSE23400 | SORCS3 | 22986 | 215522_at | -0.0086 | 0.6625 | |
| GSE26886 | SORCS3 | 22986 | 215522_at | 0.0114 | 0.9215 | |
| GSE29001 | SORCS3 | 22986 | 215522_at | 0.0315 | 0.7756 | |
| GSE38129 | SORCS3 | 22986 | 215522_at | -0.0601 | 0.3299 | |
| GSE45670 | SORCS3 | 22986 | 215522_at | 0.0317 | 0.6908 | |
| GSE53622 | SORCS3 | 22986 | 76768 | 0.0582 | 0.4599 | |
| GSE53624 | SORCS3 | 22986 | 76768 | 0.1298 | 0.1754 | |
| GSE63941 | SORCS3 | 22986 | 215522_at | 0.1364 | 0.3131 | |
| GSE77861 | SORCS3 | 22986 | 215522_at | -0.0786 | 0.4993 | |
| GSE97050 | SORCS3 | 22986 | A_33_P3420889 | 0.0190 | 0.9500 | |
| TCGA | SORCS3 | 22986 | RNAseq | -2.3029 | 0.0484 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SORCS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SORCS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SORCS3 | 22986 | 1 | 9 | 20 | |
| GSE20123 | SORCS3 | 22986 | 1 | 8 | 21 | |
| GSE43470 | SORCS3 | 22986 | 0 | 7 | 36 | |
| GSE46452 | SORCS3 | 22986 | 0 | 11 | 48 | |
| GSE47630 | SORCS3 | 22986 | 2 | 14 | 24 | |
| GSE54993 | SORCS3 | 22986 | 8 | 0 | 62 | |
| GSE54994 | SORCS3 | 22986 | 1 | 10 | 42 | |
| GSE60625 | SORCS3 | 22986 | 0 | 0 | 11 | |
| GSE74703 | SORCS3 | 22986 | 0 | 5 | 31 | |
| GSE74704 | SORCS3 | 22986 | 1 | 4 | 15 | |
| TCGA | SORCS3 | 22986 | 5 | 29 | 62 |
Total number of gains: 19; Total number of losses: 97; Total Number of normals: 372.
Somatic mutations of SORCS3:
Generating mutation plots.
Highly correlated genes for SORCS3:
Showing top 20/474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SORCS3 | KCNK9 | 0.82618 | 3 | 0 | 3 |
| SORCS3 | C9orf153 | 0.823404 | 3 | 0 | 3 |
| SORCS3 | YY2 | 0.823334 | 3 | 0 | 3 |
| SORCS3 | STRC | 0.813765 | 3 | 0 | 3 |
| SORCS3 | C19orf71 | 0.796071 | 3 | 0 | 3 |
| SORCS3 | PLA2G2C | 0.7929 | 3 | 0 | 3 |
| SORCS3 | MRGPRG | 0.786342 | 3 | 0 | 3 |
| SORCS3 | OR2T27 | 0.783585 | 3 | 0 | 3 |
| SORCS3 | PRDM13 | 0.783255 | 3 | 0 | 3 |
| SORCS3 | SPACA3 | 0.782311 | 3 | 0 | 3 |
| SORCS3 | INSC | 0.779015 | 3 | 0 | 3 |
| SORCS3 | OR10H1 | 0.778328 | 4 | 0 | 4 |
| SORCS3 | DCDC1 | 0.776315 | 3 | 0 | 3 |
| SORCS3 | OR2T1 | 0.776175 | 3 | 0 | 3 |
| SORCS3 | OR10AD1 | 0.770842 | 3 | 0 | 3 |
| SORCS3 | BBC3 | 0.766139 | 3 | 0 | 3 |
| SORCS3 | ZAN | 0.763046 | 3 | 0 | 3 |
| SORCS3 | DEFB121 | 0.761711 | 3 | 0 | 3 |
| SORCS3 | KRTAP10-12 | 0.761307 | 3 | 0 | 3 |
| SORCS3 | PRSS38 | 0.756731 | 3 | 0 | 3 |
For details and further investigation, click here
