| Full name: mutS homolog 3 | Alias Symbol: DUP|MRP1 | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 4437 | HGNC ID: HGNC:7326 | Ensembl Gene: ENSG00000113318 | OMIM ID: 600887 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MSH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MSH3 | 4437 | 210947_s_at | -0.3547 | 0.3205 | |
| GSE20347 | MSH3 | 4437 | 205887_x_at | -0.0823 | 0.2827 | |
| GSE23400 | MSH3 | 4437 | 205887_x_at | -0.0096 | 0.7103 | |
| GSE26886 | MSH3 | 4437 | 210947_s_at | -0.1532 | 0.4287 | |
| GSE29001 | MSH3 | 4437 | 205887_x_at | -0.0066 | 0.9698 | |
| GSE38129 | MSH3 | 4437 | 210947_s_at | -0.2935 | 0.0228 | |
| GSE45670 | MSH3 | 4437 | 210947_s_at | -0.2583 | 0.0278 | |
| GSE53622 | MSH3 | 4437 | 103241 | -0.1771 | 0.0022 | |
| GSE53624 | MSH3 | 4437 | 103241 | -0.2372 | 0.0000 | |
| GSE63941 | MSH3 | 4437 | 210947_s_at | -0.3887 | 0.2467 | |
| GSE77861 | MSH3 | 4437 | 210947_s_at | -0.1972 | 0.2797 | |
| GSE97050 | MSH3 | 4437 | A_23_P122001 | -0.0432 | 0.8624 | |
| SRP007169 | MSH3 | 4437 | RNAseq | -0.1810 | 0.6948 | |
| SRP008496 | MSH3 | 4437 | RNAseq | -0.2896 | 0.2421 | |
| SRP064894 | MSH3 | 4437 | RNAseq | -0.2525 | 0.1290 | |
| SRP133303 | MSH3 | 4437 | RNAseq | -0.0683 | 0.7307 | |
| SRP159526 | MSH3 | 4437 | RNAseq | -0.3757 | 0.2172 | |
| SRP193095 | MSH3 | 4437 | RNAseq | -0.4838 | 0.0000 | |
| SRP219564 | MSH3 | 4437 | RNAseq | -0.4559 | 0.1454 | |
| TCGA | MSH3 | 4437 | RNAseq | -0.0097 | 0.8607 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MSH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MSH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MSH3 | 4437 | 1 | 13 | 16 | |
| GSE20123 | MSH3 | 4437 | 1 | 13 | 16 | |
| GSE43470 | MSH3 | 4437 | 1 | 11 | 31 | |
| GSE46452 | MSH3 | 4437 | 0 | 28 | 31 | |
| GSE47630 | MSH3 | 4437 | 1 | 19 | 20 | |
| GSE54993 | MSH3 | 4437 | 8 | 1 | 61 | |
| GSE54994 | MSH3 | 4437 | 2 | 18 | 33 | |
| GSE60625 | MSH3 | 4437 | 0 | 0 | 11 | |
| GSE74703 | MSH3 | 4437 | 1 | 7 | 28 | |
| GSE74704 | MSH3 | 4437 | 1 | 6 | 13 | |
| TCGA | MSH3 | 4437 | 5 | 49 | 42 |
Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.
Somatic mutations of MSH3:
Generating mutation plots.
Highly correlated genes for MSH3:
Showing top 20/445 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MSH3 | RNF144B | 0.763464 | 3 | 0 | 3 |
| MSH3 | MED4 | 0.758361 | 4 | 0 | 4 |
| MSH3 | ANKMY2 | 0.735154 | 3 | 0 | 3 |
| MSH3 | SON | 0.733983 | 3 | 0 | 3 |
| MSH3 | EIF3J | 0.719727 | 3 | 0 | 3 |
| MSH3 | ZFYVE26 | 0.719518 | 3 | 0 | 3 |
| MSH3 | ATP6V1G1 | 0.716141 | 3 | 0 | 3 |
| MSH3 | SUGT1 | 0.715285 | 3 | 0 | 3 |
| MSH3 | ZNF273 | 0.712027 | 4 | 0 | 4 |
| MSH3 | MICU2 | 0.70134 | 3 | 0 | 3 |
| MSH3 | KIAA1191 | 0.694245 | 3 | 0 | 3 |
| MSH3 | ERCC8 | 0.69282 | 3 | 0 | 3 |
| MSH3 | USP32 | 0.689583 | 3 | 0 | 3 |
| MSH3 | TRERF1 | 0.689202 | 4 | 0 | 4 |
| MSH3 | CNOT4 | 0.688976 | 4 | 0 | 4 |
| MSH3 | SAP30L | 0.68368 | 3 | 0 | 3 |
| MSH3 | C11orf54 | 0.676473 | 4 | 0 | 3 |
| MSH3 | TPTE | 0.674659 | 3 | 0 | 3 |
| MSH3 | ZNF354C | 0.672913 | 3 | 0 | 3 |
| MSH3 | FAM110C | 0.672442 | 3 | 0 | 3 |
For details and further investigation, click here
