ERCC8

 

Full name: ERCC excision repair 8, CSA ubiquitin ligase complex subunit Alias Symbol: CSA
Type: protein-coding gene Cytoband: 5q12.1
Entrez ID: 1161 HGNC ID: HGNC:3439 Ensembl Gene: ENSG00000049167 OMIM ID: 609412
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ERCC8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ERCC8 1161 205162_at 0.2037 0.6144
GSE20347 ERCC8 1161 205162_at 0.0843 0.3520
GSE23400 ERCC8 1161 205162_at 0.0336 0.3072
GSE26886 ERCC8 1161 205162_at -0.0181 0.9552
GSE29001 ERCC8 1161 205162_at 0.1061 0.6361
GSE38129 ERCC8 1161 205162_at 0.1383 0.1056
GSE45670 ERCC8 1161 205162_at 0.0571 0.7157
GSE53622 ERCC8 1161 23978 -0.3238 0.0002
GSE53624 ERCC8 1161 23978 0.1205 0.1609
GSE63941 ERCC8 1161 1554883_a_at 1.3801 0.0036
GSE77861 ERCC8 1161 205162_at -0.1913 0.2798
GSE97050 ERCC8 1161 A_23_P58521 0.1901 0.4075
SRP007169 ERCC8 1161 RNAseq 0.4391 0.2998
SRP008496 ERCC8 1161 RNAseq 0.3776 0.2168
SRP064894 ERCC8 1161 RNAseq 0.1136 0.4178
SRP133303 ERCC8 1161 RNAseq 0.3498 0.0247
SRP159526 ERCC8 1161 RNAseq 0.3846 0.3550
SRP193095 ERCC8 1161 RNAseq -0.2628 0.0477
SRP219564 ERCC8 1161 RNAseq -0.3267 0.3672
TCGA ERCC8 1161 RNAseq -0.0371 0.5860

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ERCC8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ERCC8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ERCC8 1161 0 13 17
GSE20123 ERCC8 1161 0 13 17
GSE43470 ERCC8 1161 1 12 30
GSE46452 ERCC8 1161 0 28 31
GSE47630 ERCC8 1161 2 17 21
GSE54993 ERCC8 1161 8 1 61
GSE54994 ERCC8 1161 1 19 33
GSE60625 ERCC8 1161 0 0 11
GSE74703 ERCC8 1161 1 9 26
GSE74704 ERCC8 1161 0 6 14
TCGA ERCC8 1161 5 49 42

Total number of gains: 18; Total number of losses: 167; Total Number of normals: 303.  

 

Somatic mutations of ERCC8:

 

Generating mutation plots.

 

Highly correlated genes for ERCC8:

 

Showing top 20/287 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ERCC8PDE8A0.800195303
ERCC8CSNK2B0.774695303
ERCC8MPHOSPH60.75355303
ERCC8PTGES30.750118303
ERCC8RPP380.747289303
ERCC8RACGAP10.746004303
ERCC8RNF1380.738298303
ERCC8MPP60.734662404
ERCC8ATF10.721025303
ERCC8SNAPC10.718075303
ERCC8BORA0.714685303
ERCC8F120.712035303
ERCC8IDH3A0.710169303
ERCC8C1orf560.706588303
ERCC8MRPL370.702567303
ERCC8PIK3R10.700739303
ERCC8CCT6A0.700254403
ERCC8CDC730.699619303
ERCC8LRRC280.698859303
ERCC8PSMC40.696663303

For details and further investigation, click here