| Full name: mediator complex subunit 4 | Alias Symbol: HSPC126|DRIP36|TRAP36 | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 29079 | HGNC ID: HGNC:17903 | Ensembl Gene: ENSG00000136146 | OMIM ID: 605718 |
| Drug and gene relationship at DGIdb | |||
Expression of MED4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED4 | 29079 | 217843_s_at | -0.2318 | 0.6181 | |
| GSE20347 | MED4 | 29079 | 217843_s_at | -0.3581 | 0.0441 | |
| GSE23400 | MED4 | 29079 | 217843_s_at | 0.0805 | 0.3359 | |
| GSE26886 | MED4 | 29079 | 217843_s_at | 0.0979 | 0.7256 | |
| GSE29001 | MED4 | 29079 | 217843_s_at | -0.0964 | 0.7858 | |
| GSE38129 | MED4 | 29079 | 217843_s_at | -0.1330 | 0.3217 | |
| GSE45670 | MED4 | 29079 | 217843_s_at | -0.0461 | 0.7383 | |
| GSE53622 | MED4 | 29079 | 7008 | -0.3426 | 0.0000 | |
| GSE53624 | MED4 | 29079 | 7008 | -0.2158 | 0.0002 | |
| GSE63941 | MED4 | 29079 | 217843_s_at | -0.3930 | 0.2930 | |
| GSE77861 | MED4 | 29079 | 217843_s_at | -0.1073 | 0.6465 | |
| GSE97050 | MED4 | 29079 | A_23_P128543 | -0.0695 | 0.8138 | |
| SRP007169 | MED4 | 29079 | RNAseq | -0.5648 | 0.1402 | |
| SRP008496 | MED4 | 29079 | RNAseq | -0.3654 | 0.1859 | |
| SRP064894 | MED4 | 29079 | RNAseq | -0.0021 | 0.9894 | |
| SRP133303 | MED4 | 29079 | RNAseq | -0.1432 | 0.2849 | |
| SRP159526 | MED4 | 29079 | RNAseq | -0.5356 | 0.0013 | |
| SRP193095 | MED4 | 29079 | RNAseq | -0.3917 | 0.0002 | |
| SRP219564 | MED4 | 29079 | RNAseq | -0.2686 | 0.0940 | |
| TCGA | MED4 | 29079 | RNAseq | 0.0630 | 0.2221 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MED4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED4 | 29079 | 0 | 13 | 17 | |
| GSE20123 | MED4 | 29079 | 0 | 12 | 18 | |
| GSE43470 | MED4 | 29079 | 3 | 13 | 27 | |
| GSE46452 | MED4 | 29079 | 0 | 32 | 27 | |
| GSE47630 | MED4 | 29079 | 2 | 27 | 11 | |
| GSE54993 | MED4 | 29079 | 12 | 2 | 56 | |
| GSE54994 | MED4 | 29079 | 1 | 17 | 35 | |
| GSE60625 | MED4 | 29079 | 0 | 3 | 8 | |
| GSE74703 | MED4 | 29079 | 3 | 10 | 23 | |
| GSE74704 | MED4 | 29079 | 0 | 9 | 11 | |
| TCGA | MED4 | 29079 | 8 | 38 | 50 |
Total number of gains: 29; Total number of losses: 176; Total Number of normals: 283.
Somatic mutations of MED4:
Generating mutation plots.
Highly correlated genes for MED4:
Showing top 20/418 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED4 | ARHGEF3 | 0.771219 | 3 | 0 | 3 |
| MED4 | MFN1 | 0.763609 | 4 | 0 | 4 |
| MED4 | TRAPPC6B | 0.76248 | 3 | 0 | 3 |
| MED4 | MSH3 | 0.758361 | 4 | 0 | 4 |
| MED4 | MCCC1 | 0.750624 | 3 | 0 | 3 |
| MED4 | SCRN3 | 0.74904 | 3 | 0 | 3 |
| MED4 | THUMPD2 | 0.736884 | 3 | 0 | 3 |
| MED4 | ZDHHC17 | 0.733694 | 3 | 0 | 3 |
| MED4 | ZNF570 | 0.726726 | 4 | 0 | 4 |
| MED4 | HINT3 | 0.723624 | 3 | 0 | 3 |
| MED4 | ZNF268 | 0.718695 | 4 | 0 | 4 |
| MED4 | HERC4 | 0.71714 | 4 | 0 | 4 |
| MED4 | TTC39B | 0.716272 | 3 | 0 | 3 |
| MED4 | TAF7 | 0.716145 | 4 | 0 | 4 |
| MED4 | SLC37A3 | 0.713149 | 3 | 0 | 3 |
| MED4 | VPS41 | 0.706991 | 4 | 0 | 4 |
| MED4 | RAB22A | 0.702998 | 3 | 0 | 3 |
| MED4 | RNF135 | 0.697958 | 4 | 0 | 3 |
| MED4 | OSBPL8 | 0.697396 | 3 | 0 | 3 |
| MED4 | TRNT1 | 0.697214 | 3 | 0 | 3 |
For details and further investigation, click here
