| Full name: SGT1 homolog, MIS12 kinetochore complex assembly cochaperone | Alias Symbol: SGT1 | ||
| Type: protein-coding gene | Cytoband: 13q14.3 | ||
| Entrez ID: 10910 | HGNC ID: HGNC:16987 | Ensembl Gene: ENSG00000165416 | OMIM ID: 604098 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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SUGT1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
Expression of SUGT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SUGT1 | 10910 | 223329_x_at | -0.4878 | 0.2900 | |
| GSE26886 | SUGT1 | 10910 | 223329_x_at | 0.0266 | 0.8678 | |
| GSE45670 | SUGT1 | 10910 | 223329_x_at | 0.1310 | 0.3514 | |
| GSE53622 | SUGT1 | 10910 | 69399 | -0.4531 | 0.0000 | |
| GSE53624 | SUGT1 | 10910 | 69399 | -0.6771 | 0.0000 | |
| GSE63941 | SUGT1 | 10910 | 223329_x_at | -0.4580 | 0.2633 | |
| GSE77861 | SUGT1 | 10910 | 223329_x_at | -0.1827 | 0.4743 | |
| GSE97050 | SUGT1 | 10910 | A_24_P280706 | -0.0933 | 0.6358 | |
| SRP007169 | SUGT1 | 10910 | RNAseq | -0.6227 | 0.0826 | |
| SRP008496 | SUGT1 | 10910 | RNAseq | -0.2387 | 0.4602 | |
| SRP064894 | SUGT1 | 10910 | RNAseq | -0.0055 | 0.9681 | |
| SRP133303 | SUGT1 | 10910 | RNAseq | -0.3767 | 0.0259 | |
| SRP159526 | SUGT1 | 10910 | RNAseq | -0.7381 | 0.0011 | |
| SRP193095 | SUGT1 | 10910 | RNAseq | -0.3752 | 0.0019 | |
| SRP219564 | SUGT1 | 10910 | RNAseq | -0.3796 | 0.0466 | |
| TCGA | SUGT1 | 10910 | RNAseq | 0.0431 | 0.4327 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SUGT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SUGT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SUGT1 | 10910 | 2 | 12 | 16 | |
| GSE20123 | SUGT1 | 10910 | 2 | 11 | 17 | |
| GSE43470 | SUGT1 | 10910 | 1 | 12 | 30 | |
| GSE46452 | SUGT1 | 10910 | 0 | 32 | 27 | |
| GSE47630 | SUGT1 | 10910 | 2 | 27 | 11 | |
| GSE54993 | SUGT1 | 10910 | 12 | 2 | 56 | |
| GSE54994 | SUGT1 | 10910 | 1 | 15 | 37 | |
| GSE60625 | SUGT1 | 10910 | 0 | 3 | 8 | |
| GSE74703 | SUGT1 | 10910 | 1 | 10 | 25 | |
| GSE74704 | SUGT1 | 10910 | 0 | 9 | 11 | |
| TCGA | SUGT1 | 10910 | 10 | 35 | 51 |
Total number of gains: 31; Total number of losses: 168; Total Number of normals: 289.
Somatic mutations of SUGT1:
Generating mutation plots.
Highly correlated genes for SUGT1:
Showing top 20/295 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SUGT1 | EIF2D | 0.782911 | 3 | 0 | 3 |
| SUGT1 | SLC25A46 | 0.78179 | 3 | 0 | 3 |
| SUGT1 | EBPL | 0.772948 | 3 | 0 | 3 |
| SUGT1 | BAG5 | 0.753421 | 3 | 0 | 3 |
| SUGT1 | CAMK2D | 0.735963 | 3 | 0 | 3 |
| SUGT1 | PRELP | 0.730895 | 3 | 0 | 3 |
| SUGT1 | SETD2 | 0.73059 | 3 | 0 | 3 |
| SUGT1 | NDUFS1 | 0.728818 | 3 | 0 | 3 |
| SUGT1 | PFKFB3 | 0.726754 | 3 | 0 | 3 |
| SUGT1 | RAP2C | 0.725597 | 3 | 0 | 3 |
| SUGT1 | PEX3 | 0.720026 | 3 | 0 | 3 |
| SUGT1 | MSH3 | 0.715285 | 3 | 0 | 3 |
| SUGT1 | MITD1 | 0.712522 | 3 | 0 | 3 |
| SUGT1 | PGGT1B | 0.71237 | 5 | 0 | 5 |
| SUGT1 | CPEB2 | 0.712201 | 4 | 0 | 4 |
| SUGT1 | LAMTOR3 | 0.71198 | 3 | 0 | 3 |
| SUGT1 | TPP2 | 0.709927 | 4 | 0 | 3 |
| SUGT1 | PDE12 | 0.708358 | 4 | 0 | 3 |
| SUGT1 | RALA | 0.708051 | 3 | 0 | 3 |
| SUGT1 | RANBP6 | 0.707453 | 3 | 0 | 3 |
For details and further investigation, click here
