PPP1CC

 

Full name: protein phosphatase 1 catalytic subunit gamma Alias Symbol: PP1C|PP1gamma
Type: protein-coding gene Cytoband: 12q24.11
Entrez ID: 5501 HGNC ID: HGNC:9283 Ensembl Gene: ENSG00000186298 OMIM ID: 176914
Drug and gene relationship at DGIdb
Screen Evidence:

 

PPP1CC involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04720Long-term potentiation
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04921Oxytocin signaling pathway
hsa04931Insulin resistance
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05168Herpes simplex infection
hsa05205Proteoglycans in cancer

 

Expression of PPP1CC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPP1CC 5501 200726_at 0.1535 0.7192
GSE20347 PPP1CC 5501 200726_at 0.3174 0.0036
GSE23400 PPP1CC 5501 200726_at 0.1759 0.0058
GSE26886 PPP1CC 5501 200726_at -0.3705 0.0582
GSE29001 PPP1CC 5501 200726_at 0.3172 0.1537
GSE38129 PPP1CC 5501 200726_at 0.2043 0.0296
GSE45670 PPP1CC 5501 200726_at -0.1664 0.1066
GSE53622 PPP1CC 5501 34505 0.0483 0.2675
GSE53624 PPP1CC 5501 26679 0.0112 0.8630
GSE63941 PPP1CC 5501 200726_at 1.0458 0.0003
GSE77861 PPP1CC 5501 200726_at 0.1303 0.6760
GSE97050 PPP1CC 5501 A_24_P386771 0.0541 0.8194
SRP007169 PPP1CC 5501 RNAseq -0.1897 0.5521
SRP008496 PPP1CC 5501 RNAseq -0.1181 0.5314
SRP064894 PPP1CC 5501 RNAseq -0.3583 0.0011
SRP133303 PPP1CC 5501 RNAseq 0.0647 0.6723
SRP159526 PPP1CC 5501 RNAseq -0.0507 0.7932
SRP193095 PPP1CC 5501 RNAseq -0.3916 0.0014
SRP219564 PPP1CC 5501 RNAseq -0.6995 0.0023
TCGA PPP1CC 5501 RNAseq 0.0477 0.2484

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PPP1CC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPP1CC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPP1CC 5501 5 3 22
GSE20123 PPP1CC 5501 5 3 22
GSE43470 PPP1CC 5501 2 1 40
GSE46452 PPP1CC 5501 9 1 49
GSE47630 PPP1CC 5501 9 3 28
GSE54993 PPP1CC 5501 0 5 65
GSE54994 PPP1CC 5501 5 2 46
GSE60625 PPP1CC 5501 0 0 11
GSE74703 PPP1CC 5501 2 0 34
GSE74704 PPP1CC 5501 2 2 16
TCGA PPP1CC 5501 22 11 63

Total number of gains: 61; Total number of losses: 31; Total Number of normals: 396.  

 

Somatic mutations of PPP1CC:

 

Generating mutation plots.

 

Highly correlated genes for PPP1CC:

 

Showing top 20/695 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPP1CCUSP210.791026303
PPP1CCSAE10.788183303
PPP1CCZNF354C0.785711303
PPP1CCNAA300.780086303
PPP1CCATIC0.77673303
PPP1CCZFX0.768798303
PPP1CCCRBN0.761811303
PPP1CCC18orf540.756466303
PPP1CCRTN4IP10.753314403
PPP1CCCMTM40.742769303
PPP1CCMRPL370.732135404
PPP1CCBMI10.726173303
PPP1CCPIK3C2A0.720179404
PPP1CCMTX20.719527404
PPP1CCKIAA1324L0.714507403
PPP1CCSORL10.711476303
PPP1CCGET40.702396303
PPP1CCSYT170.701397303
PPP1CCCHCHD50.699181303
PPP1CCFBXO160.698061403

For details and further investigation, click here