SRC

 

Full name: SRC proto-oncogene, non-receptor tyrosine kinase Alias Symbol: ASV|c-src
Type: protein-coding gene Cytoband: 20q11.23
Entrez ID: 6714 HGNC ID: HGNC:11283 Ensembl Gene: ENSG00000197122 OMIM ID: 190090
Drug and gene relationship at DGIdb
Screen Evidence:

 

SRC involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04540Gap junction
hsa04611Platelet activation
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05205Proteoglycans in cancer

 

Expression of SRC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SRC 6714 213324_at 0.8038 0.0603
GSE20347 SRC 6714 213324_at 0.0970 0.4576
GSE23400 SRC 6714 213324_at 0.0566 0.2702
GSE26886 SRC 6714 213324_at -0.7268 0.0011
GSE29001 SRC 6714 213324_at 0.2930 0.5898
GSE38129 SRC 6714 213324_at 0.1985 0.0474
GSE45670 SRC 6714 213324_at 0.5554 0.0000
GSE53622 SRC 6714 74229 0.5042 0.0000
GSE53624 SRC 6714 74229 0.3535 0.0000
GSE63941 SRC 6714 213324_at -0.3324 0.4561
GSE77861 SRC 6714 213324_at 0.2604 0.3535
GSE97050 SRC 6714 A_23_P308603 0.2058 0.3385
SRP007169 SRC 6714 RNAseq 0.0557 0.8730
SRP008496 SRC 6714 RNAseq 0.1057 0.6819
SRP064894 SRC 6714 RNAseq 0.1270 0.5020
SRP133303 SRC 6714 RNAseq 0.3130 0.0286
SRP159526 SRC 6714 RNAseq 0.0979 0.7307
SRP193095 SRC 6714 RNAseq 0.0033 0.9848
SRP219564 SRC 6714 RNAseq -0.1624 0.6084
TCGA SRC 6714 RNAseq -0.0462 0.2889

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SRC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SRC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SRC 6714 14 2 14
GSE20123 SRC 6714 14 2 14
GSE43470 SRC 6714 13 0 30
GSE46452 SRC 6714 29 0 30
GSE47630 SRC 6714 24 0 16
GSE54993 SRC 6714 0 17 53
GSE54994 SRC 6714 23 0 30
GSE60625 SRC 6714 0 0 11
GSE74703 SRC 6714 11 0 25
GSE74704 SRC 6714 10 1 9
TCGA SRC 6714 47 3 46

Total number of gains: 185; Total number of losses: 25; Total Number of normals: 278.  

 

Somatic mutations of SRC:

 

Generating mutation plots.

 

Highly correlated genes for SRC:

 

Showing top 20/315 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SRCHMBOX10.797107303
SRCMTX20.72658303
SRCGRWD10.716822404
SRCPSMA10.702869303
SRCARF30.701503403
SRCBCL7B0.696511303
SRCSIPA10.695687404
SRCCOPS7A0.694445403
SRCTRAPPC10.69286303
SRCAPLP20.684985404
SRCKLHDC30.672674404
SRCNUFIP20.670417303
SRCARHGEF110.660669404
SRCARHGEF190.659839303
SRCTMEM63B0.656652403
SRCEIF3C0.656346303
SRCMDN10.654633403
SRCTEX2610.653857403
SRCPPP1R9B0.65007504
SRCDTD10.648951303

For details and further investigation, click here