| Full name: protein phosphatase 2 catalytic subunit alpha | Alias Symbol: PP2Calpha|PP2AC | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 5515 | HGNC ID: HGNC:9299 | Ensembl Gene: ENSG00000113575 | OMIM ID: 176915 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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PPP2CA involved pathways:
Expression of PPP2CA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP2CA | 5515 | 208652_at | -0.2341 | 0.5648 | |
| GSE20347 | PPP2CA | 5515 | 208652_at | -0.3850 | 0.0006 | |
| GSE23400 | PPP2CA | 5515 | 208652_at | -0.2339 | 0.0013 | |
| GSE26886 | PPP2CA | 5515 | 208652_at | -1.0319 | 0.0000 | |
| GSE29001 | PPP2CA | 5515 | 208652_at | -0.3037 | 0.4404 | |
| GSE38129 | PPP2CA | 5515 | 208652_at | -0.1841 | 0.0582 | |
| GSE45670 | PPP2CA | 5515 | 208652_at | 0.0242 | 0.9052 | |
| GSE53622 | PPP2CA | 5515 | 90070 | -0.4263 | 0.0000 | |
| GSE53624 | PPP2CA | 5515 | 90070 | -0.3188 | 0.0000 | |
| GSE63941 | PPP2CA | 5515 | 208652_at | 0.2452 | 0.5007 | |
| GSE77861 | PPP2CA | 5515 | 208652_at | -0.3687 | 0.2289 | |
| GSE97050 | PPP2CA | 5515 | A_23_P122041 | -0.0144 | 0.9713 | |
| SRP007169 | PPP2CA | 5515 | RNAseq | -1.4527 | 0.0002 | |
| SRP008496 | PPP2CA | 5515 | RNAseq | -1.4116 | 0.0000 | |
| SRP064894 | PPP2CA | 5515 | RNAseq | -0.5667 | 0.0000 | |
| SRP133303 | PPP2CA | 5515 | RNAseq | -0.0551 | 0.7491 | |
| SRP159526 | PPP2CA | 5515 | RNAseq | -0.5029 | 0.1143 | |
| SRP193095 | PPP2CA | 5515 | RNAseq | -0.6863 | 0.0000 | |
| SRP219564 | PPP2CA | 5515 | RNAseq | -0.6319 | 0.0844 | |
| TCGA | PPP2CA | 5515 | RNAseq | 0.0374 | 0.3829 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PPP2CA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP2CA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP2CA | 5515 | 2 | 11 | 17 | |
| GSE20123 | PPP2CA | 5515 | 3 | 11 | 16 | |
| GSE43470 | PPP2CA | 5515 | 2 | 8 | 33 | |
| GSE46452 | PPP2CA | 5515 | 0 | 27 | 32 | |
| GSE47630 | PPP2CA | 5515 | 0 | 21 | 19 | |
| GSE54993 | PPP2CA | 5515 | 9 | 1 | 60 | |
| GSE54994 | PPP2CA | 5515 | 2 | 14 | 37 | |
| GSE60625 | PPP2CA | 5515 | 0 | 0 | 11 | |
| GSE74703 | PPP2CA | 5515 | 2 | 5 | 29 | |
| GSE74704 | PPP2CA | 5515 | 2 | 5 | 13 | |
| TCGA | PPP2CA | 5515 | 3 | 37 | 56 |
Total number of gains: 25; Total number of losses: 140; Total Number of normals: 323.
Somatic mutations of PPP2CA:
Generating mutation plots.
Highly correlated genes for PPP2CA:
Showing top 20/1146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP2CA | BDP1 | 0.764449 | 3 | 0 | 3 |
| PPP2CA | COMMD1 | 0.760634 | 3 | 0 | 3 |
| PPP2CA | PPP1R8 | 0.753893 | 3 | 0 | 3 |
| PPP2CA | MTX2 | 0.751766 | 3 | 0 | 3 |
| PPP2CA | STX18 | 0.736083 | 3 | 0 | 3 |
| PPP2CA | VDAC1 | 0.731589 | 12 | 0 | 10 |
| PPP2CA | DPY30 | 0.730862 | 3 | 0 | 3 |
| PPP2CA | FAM174A | 0.728343 | 6 | 0 | 5 |
| PPP2CA | UGP2 | 0.728082 | 5 | 0 | 4 |
| PPP2CA | SAR1B | 0.728027 | 12 | 0 | 11 |
| PPP2CA | DNAJC15 | 0.726559 | 3 | 0 | 3 |
| PPP2CA | CUL2 | 0.725775 | 3 | 0 | 3 |
| PPP2CA | CAPNS2 | 0.725394 | 4 | 0 | 3 |
| PPP2CA | HDHD2 | 0.723822 | 3 | 0 | 3 |
| PPP2CA | FAM71F2 | 0.722844 | 3 | 0 | 3 |
| PPP2CA | ACTR3 | 0.718971 | 4 | 0 | 4 |
| PPP2CA | NAPG | 0.717481 | 3 | 0 | 3 |
| PPP2CA | UBLCP1 | 0.716211 | 5 | 0 | 5 |
| PPP2CA | HSPA4 | 0.714912 | 13 | 0 | 12 |
| PPP2CA | ARL5A | 0.713937 | 3 | 0 | 3 |
For details and further investigation, click here
