| Full name: MUS81 structure-specific endonuclease subunit | Alias Symbol: FLJ44872|SLX3 | ||
| Type: protein-coding gene | Cytoband: 11q13 | ||
| Entrez ID: 80198 | HGNC ID: HGNC:29814 | Ensembl Gene: ENSG00000172732 | OMIM ID: 606591 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MUS81:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUS81 | 80198 | 218463_s_at | 0.3247 | 0.3022 | |
| GSE20347 | MUS81 | 80198 | 218463_s_at | 0.6256 | 0.0000 | |
| GSE23400 | MUS81 | 80198 | 218463_s_at | 0.2944 | 0.0000 | |
| GSE26886 | MUS81 | 80198 | 218463_s_at | 0.5171 | 0.0021 | |
| GSE29001 | MUS81 | 80198 | 218463_s_at | 0.5833 | 0.0224 | |
| GSE38129 | MUS81 | 80198 | 218463_s_at | 0.4130 | 0.0035 | |
| GSE45670 | MUS81 | 80198 | 218463_s_at | 0.2968 | 0.0539 | |
| GSE53622 | MUS81 | 80198 | 10413 | 0.2344 | 0.0006 | |
| GSE53624 | MUS81 | 80198 | 10413 | 0.5084 | 0.0000 | |
| GSE63941 | MUS81 | 80198 | 218463_s_at | 0.5561 | 0.1365 | |
| GSE77861 | MUS81 | 80198 | 218463_s_at | 0.4822 | 0.0026 | |
| GSE97050 | MUS81 | 80198 | A_23_P161634 | 0.0185 | 0.9518 | |
| SRP007169 | MUS81 | 80198 | RNAseq | 0.6334 | 0.1454 | |
| SRP008496 | MUS81 | 80198 | RNAseq | 0.6768 | 0.0318 | |
| SRP064894 | MUS81 | 80198 | RNAseq | 0.3607 | 0.0035 | |
| SRP133303 | MUS81 | 80198 | RNAseq | 0.3190 | 0.1511 | |
| SRP159526 | MUS81 | 80198 | RNAseq | 0.2832 | 0.1365 | |
| SRP193095 | MUS81 | 80198 | RNAseq | 0.2565 | 0.0048 | |
| SRP219564 | MUS81 | 80198 | RNAseq | -0.0977 | 0.7064 | |
| TCGA | MUS81 | 80198 | RNAseq | -0.0069 | 0.8973 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MUS81 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MUS81:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUS81 | 80198 | 8 | 5 | 17 | |
| GSE20123 | MUS81 | 80198 | 8 | 5 | 17 | |
| GSE43470 | MUS81 | 80198 | 6 | 1 | 36 | |
| GSE46452 | MUS81 | 80198 | 11 | 3 | 45 | |
| GSE47630 | MUS81 | 80198 | 7 | 5 | 28 | |
| GSE54993 | MUS81 | 80198 | 3 | 0 | 67 | |
| GSE54994 | MUS81 | 80198 | 7 | 5 | 41 | |
| GSE60625 | MUS81 | 80198 | 0 | 3 | 8 | |
| GSE74703 | MUS81 | 80198 | 4 | 0 | 32 | |
| GSE74704 | MUS81 | 80198 | 6 | 3 | 11 | |
| TCGA | MUS81 | 80198 | 23 | 7 | 66 |
Total number of gains: 83; Total number of losses: 37; Total Number of normals: 368.
Somatic mutations of MUS81:
Generating mutation plots.
Highly correlated genes for MUS81:
Showing top 20/1396 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUS81 | PHF2 | 0.759193 | 3 | 0 | 3 |
| MUS81 | IRS2 | 0.759155 | 3 | 0 | 3 |
| MUS81 | KIAA0895L | 0.744247 | 3 | 0 | 3 |
| MUS81 | XPNPEP1 | 0.741648 | 3 | 0 | 3 |
| MUS81 | CCNT1 | 0.737414 | 3 | 0 | 3 |
| MUS81 | TMTC1 | 0.734501 | 3 | 0 | 3 |
| MUS81 | CYHR1 | 0.731485 | 3 | 0 | 3 |
| MUS81 | ZNF260 | 0.729136 | 3 | 0 | 3 |
| MUS81 | KIAA1257 | 0.728127 | 3 | 0 | 3 |
| MUS81 | SLC39A3 | 0.727351 | 4 | 0 | 4 |
| MUS81 | EVI5L | 0.727228 | 3 | 0 | 3 |
| MUS81 | NUFIP2 | 0.722973 | 4 | 0 | 4 |
| MUS81 | CRYBB2 | 0.720165 | 3 | 0 | 3 |
| MUS81 | KRTCAP2 | 0.719369 | 5 | 0 | 5 |
| MUS81 | RILPL1 | 0.718058 | 4 | 0 | 4 |
| MUS81 | RAB28 | 0.714724 | 3 | 0 | 3 |
| MUS81 | SOCS7 | 0.704531 | 4 | 0 | 3 |
| MUS81 | R3HDM2 | 0.703417 | 4 | 0 | 3 |
| MUS81 | SLC39A13 | 0.703151 | 6 | 0 | 6 |
| MUS81 | FAM193A | 0.700247 | 3 | 0 | 3 |
For details and further investigation, click here
