SOCS7

 

Full name: suppressor of cytokine signaling 7 Alias Symbol: NAP4|NCKAP4
Type: protein-coding gene Cytoband: 17q12
Entrez ID: 30837 HGNC ID: HGNC:29846 Ensembl Gene: ENSG00000274211 OMIM ID: 608788
Drug and gene relationship at DGIdb

 

SOCS7 involved pathways:

KEGG pathway Description View
hsa04630Jak-STAT signaling pathway
hsa04917Prolactin signaling pathway

 

Expression of SOCS7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SOCS7 30837 228662_at 0.8544 0.0250
GSE20347 SOCS7 30837 214015_at 0.0672 0.5176
GSE23400 SOCS7 30837 214015_at -0.0624 0.0765
GSE26886 SOCS7 30837 228662_at -0.0055 0.9885
GSE29001 SOCS7 30837 214015_at 0.0634 0.5524
GSE38129 SOCS7 30837 214015_at 0.0574 0.5511
GSE45670 SOCS7 30837 228662_at 0.4131 0.0869
GSE53622 SOCS7 30837 121983 0.1112 0.2118
GSE53624 SOCS7 30837 121983 0.4690 0.0000
GSE63941 SOCS7 30837 228662_at 0.7249 0.1593
GSE77861 SOCS7 30837 226572_at 0.4339 0.0347
GSE97050 SOCS7 30837 A_24_P367211 0.2187 0.6771
SRP007169 SOCS7 30837 RNAseq 1.2699 0.0129
SRP008496 SOCS7 30837 RNAseq 0.9028 0.0090
SRP064894 SOCS7 30837 RNAseq 0.1042 0.6527
SRP133303 SOCS7 30837 RNAseq -0.1250 0.4734
SRP159526 SOCS7 30837 RNAseq 0.3728 0.0598
SRP193095 SOCS7 30837 RNAseq 0.3095 0.0014
SRP219564 SOCS7 30837 RNAseq -0.1865 0.4741
TCGA SOCS7 30837 RNAseq -0.2062 0.0154

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SOCS7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SOCS7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SOCS7 30837 6 1 23
GSE20123 SOCS7 30837 6 1 23
GSE43470 SOCS7 30837 2 0 41
GSE46452 SOCS7 30837 34 0 25
GSE47630 SOCS7 30837 8 1 31
GSE54993 SOCS7 30837 3 3 64
GSE54994 SOCS7 30837 8 5 40
GSE60625 SOCS7 30837 4 0 7
GSE74703 SOCS7 30837 1 0 35
GSE74704 SOCS7 30837 3 1 16
TCGA SOCS7 30837 19 9 68

Total number of gains: 94; Total number of losses: 21; Total Number of normals: 373.  

 

Somatic mutations of SOCS7:

 

Generating mutation plots.

 

Highly correlated genes for SOCS7:

 

Showing top 20/638 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SOCS7RRAS20.816707303
SOCS7ITGB40.795503303
SOCS7ZNF6440.792336303
SOCS7ORC20.788201303
SOCS7PDE7A0.782344303
SOCS7R3HDM20.781059303
SOCS7YWHAG0.77753403
SOCS7ADRM10.774308303
SOCS7EIF5A20.772773303
SOCS7ANKRD400.768855303
SOCS7TRMT1120.766503303
SOCS7SCAF40.763719303
SOCS7NUDC0.75785303
SOCS7IFFO20.755192303
SOCS7GPR1530.744103303
SOCS7PET1170.743891303
SOCS7LIPT10.743612303
SOCS7ALKBH60.74345303
SOCS7NCOA60.742952303
SOCS7TP53I130.742092404

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