| Full name: nascent polypeptide associated complex subunit alpha | Alias Symbol: NACA1 | ||
| Type: protein-coding gene | Cytoband: 12q23-q24.1 | ||
| Entrez ID: 4666 | HGNC ID: HGNC:7629 | Ensembl Gene: ENSG00000196531 | OMIM ID: 601234 |
Screen Evidence:
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Expression of NACA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NACA | 4666 | 208635_x_at | -0.3164 | 0.1246 | |
| GSE20347 | NACA | 4666 | 200735_x_at | -0.2899 | 0.0017 | |
| GSE23400 | NACA | 4666 | 208635_x_at | -0.1418 | 0.0175 | |
| GSE26886 | NACA | 4666 | 200735_x_at | 0.0907 | 0.6464 | |
| GSE29001 | NACA | 4666 | 208635_x_at | -0.6384 | 0.0439 | |
| GSE38129 | NACA | 4666 | 208635_x_at | -0.1498 | 0.0305 | |
| GSE45670 | NACA | 4666 | 208635_x_at | -0.2779 | 0.0008 | |
| GSE63941 | NACA | 4666 | 208635_x_at | 0.3774 | 0.0683 | |
| GSE77861 | NACA | 4666 | 208635_x_at | -0.2871 | 0.0558 | |
| GSE97050 | NACA | 4666 | A_23_P162228 | -0.6896 | 0.1293 | |
| SRP007169 | NACA | 4666 | RNAseq | -0.3867 | 0.2533 | |
| SRP008496 | NACA | 4666 | RNAseq | -0.1564 | 0.5267 | |
| SRP064894 | NACA | 4666 | RNAseq | -0.6990 | 0.0001 | |
| SRP133303 | NACA | 4666 | RNAseq | -0.5724 | 0.0007 | |
| SRP159526 | NACA | 4666 | RNAseq | -0.9366 | 0.0001 | |
| SRP193095 | NACA | 4666 | RNAseq | -1.1573 | 0.0000 | |
| SRP219564 | NACA | 4666 | RNAseq | -0.6911 | 0.0226 | |
| TCGA | NACA | 4666 | RNAseq | -0.0069 | 0.8611 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NACA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NACA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NACA | 4666 | 7 | 2 | 21 | |
| GSE20123 | NACA | 4666 | 7 | 1 | 22 | |
| GSE43470 | NACA | 4666 | 3 | 0 | 40 | |
| GSE46452 | NACA | 4666 | 8 | 1 | 50 | |
| GSE47630 | NACA | 4666 | 10 | 2 | 28 | |
| GSE54993 | NACA | 4666 | 0 | 5 | 65 | |
| GSE54994 | NACA | 4666 | 4 | 1 | 48 | |
| GSE60625 | NACA | 4666 | 0 | 0 | 11 | |
| GSE74703 | NACA | 4666 | 3 | 0 | 33 | |
| GSE74704 | NACA | 4666 | 4 | 1 | 15 | |
| TCGA | NACA | 4666 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of NACA:
Generating mutation plots.
Highly correlated genes for NACA:
Showing top 20/782 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NACA | OGN | 0.732012 | 3 | 0 | 3 |
| NACA | RPL29 | 0.723488 | 10 | 0 | 8 |
| NACA | NOA1 | 0.716316 | 3 | 0 | 3 |
| NACA | TGFBR3 | 0.71343 | 4 | 0 | 4 |
| NACA | RPL6 | 0.712989 | 11 | 0 | 11 |
| NACA | MACROD2 | 0.707863 | 3 | 0 | 3 |
| NACA | ZMAT1 | 0.707688 | 4 | 0 | 4 |
| NACA | RPL11 | 0.703855 | 11 | 0 | 11 |
| NACA | FAM214A | 0.701327 | 3 | 0 | 3 |
| NACA | HEIH | 0.696286 | 3 | 0 | 3 |
| NACA | YAP1 | 0.687725 | 3 | 0 | 3 |
| NACA | RPL10A | 0.687348 | 9 | 0 | 8 |
| NACA | ITGA9 | 0.686109 | 3 | 0 | 3 |
| NACA | PFDN5 | 0.685839 | 10 | 0 | 9 |
| NACA | SH3BGRL2 | 0.685238 | 4 | 0 | 4 |
| NACA | CCNDBP1 | 0.683853 | 4 | 0 | 4 |
| NACA | GNAQ | 0.683752 | 4 | 0 | 3 |
| NACA | TAB3 | 0.678642 | 4 | 0 | 4 |
| NACA | CYP3A43 | 0.677941 | 3 | 0 | 3 |
| NACA | ZBTB16 | 0.677916 | 3 | 0 | 3 |
For details and further investigation, click here
