| Full name: Yes associated protein 1 | Alias Symbol: YAP65 | ||
| Type: protein-coding gene | Cytoband: 11q22.1 | ||
| Entrez ID: 10413 | HGNC ID: HGNC:16262 | Ensembl Gene: ENSG00000137693 | OMIM ID: 606608 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
YAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of YAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | YAP1 | 10413 | 224894_at | -0.9439 | 0.0357 | |
| GSE20347 | YAP1 | 10413 | 213342_at | -0.0585 | 0.9312 | |
| GSE23400 | YAP1 | 10413 | 213342_at | -0.0848 | 0.6930 | |
| GSE26886 | YAP1 | 10413 | 224894_at | -0.7196 | 0.0079 | |
| GSE29001 | YAP1 | 10413 | 213342_at | -0.9934 | 0.0322 | |
| GSE38129 | YAP1 | 10413 | 213342_at | -0.0095 | 0.9848 | |
| GSE45670 | YAP1 | 10413 | 224894_at | -0.2812 | 0.3361 | |
| GSE63941 | YAP1 | 10413 | 224894_at | -1.2628 | 0.1456 | |
| GSE77861 | YAP1 | 10413 | 224894_at | -0.4734 | 0.0882 | |
| GSE97050 | YAP1 | 10413 | A_23_P104762 | -0.1911 | 0.6635 | |
| SRP007169 | YAP1 | 10413 | RNAseq | 1.3803 | 0.1421 | |
| SRP008496 | YAP1 | 10413 | RNAseq | -0.9569 | 0.0006 | |
| SRP064894 | YAP1 | 10413 | RNAseq | -0.5928 | 0.0284 | |
| SRP133303 | YAP1 | 10413 | RNAseq | -0.6503 | 0.0012 | |
| SRP159526 | YAP1 | 10413 | RNAseq | -1.0017 | 0.0009 | |
| SRP193095 | YAP1 | 10413 | RNAseq | -0.8520 | 0.0000 | |
| SRP219564 | YAP1 | 10413 | RNAseq | -0.0354 | 0.9497 | |
| TCGA | YAP1 | 10413 | RNAseq | -0.0864 | 0.1445 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by YAP1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of YAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | YAP1 | 10413 | 5 | 8 | 17 | |
| GSE20123 | YAP1 | 10413 | 5 | 8 | 17 | |
| GSE43470 | YAP1 | 10413 | 6 | 5 | 32 | |
| GSE46452 | YAP1 | 10413 | 5 | 24 | 30 | |
| GSE47630 | YAP1 | 10413 | 2 | 19 | 19 | |
| GSE54993 | YAP1 | 10413 | 9 | 2 | 59 | |
| GSE54994 | YAP1 | 10413 | 6 | 18 | 29 | |
| GSE60625 | YAP1 | 10413 | 0 | 3 | 8 | |
| GSE74703 | YAP1 | 10413 | 4 | 4 | 28 | |
| GSE74704 | YAP1 | 10413 | 5 | 4 | 11 | |
| TCGA | YAP1 | 10413 | 11 | 44 | 41 |
Total number of gains: 58; Total number of losses: 139; Total Number of normals: 291.
Somatic mutations of YAP1:
Generating mutation plots.
Highly correlated genes for YAP1:
Showing top 20/740 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| YAP1 | PRDX2 | 0.797682 | 3 | 0 | 3 |
| YAP1 | BECN1 | 0.77899 | 3 | 0 | 3 |
| YAP1 | CRIM1 | 0.761955 | 3 | 0 | 3 |
| YAP1 | SRP14 | 0.761625 | 4 | 0 | 3 |
| YAP1 | MBNL3 | 0.756826 | 3 | 0 | 3 |
| YAP1 | ARL4A | 0.747801 | 4 | 0 | 3 |
| YAP1 | CUL4B | 0.742438 | 4 | 0 | 4 |
| YAP1 | TET2 | 0.737519 | 3 | 0 | 3 |
| YAP1 | SPIN4 | 0.73534 | 3 | 0 | 3 |
| YAP1 | BDKRB1 | 0.734381 | 3 | 0 | 3 |
| YAP1 | BIRC2 | 0.733025 | 8 | 0 | 7 |
| YAP1 | SLC16A14 | 0.732034 | 3 | 0 | 3 |
| YAP1 | KLHL9 | 0.731659 | 3 | 0 | 3 |
| YAP1 | TMPRSS11B | 0.7312 | 3 | 0 | 3 |
| YAP1 | XK | 0.731038 | 3 | 0 | 3 |
| YAP1 | HSPB8 | 0.72999 | 4 | 0 | 4 |
| YAP1 | PIAS1 | 0.727401 | 4 | 0 | 4 |
| YAP1 | SPG11 | 0.726676 | 3 | 0 | 3 |
| YAP1 | SNX3 | 0.724258 | 4 | 0 | 4 |
| YAP1 | STT3B | 0.723972 | 4 | 0 | 3 |
For details and further investigation, click here
