ITGA9

 

Full name: integrin subunit alpha 9 Alias Symbol: RLC|ITGA4L|ALPHA-RLC
Type: protein-coding gene Cytoband: 3p22.2
Entrez ID: 3680 HGNC ID: HGNC:6145 Ensembl Gene: ENSG00000144668 OMIM ID: 603963
Drug and gene relationship at DGIdb

 

ITGA9 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton

 

Expression of ITGA9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITGA9 3680 227297_at -1.7289 0.0962
GSE20347 ITGA9 3680 206009_at -0.0403 0.7642
GSE23400 ITGA9 3680 206009_at -0.1874 0.0000
GSE26886 ITGA9 3680 227297_at 0.3137 0.4270
GSE29001 ITGA9 3680 206009_at -0.0512 0.8226
GSE38129 ITGA9 3680 206009_at -0.3257 0.0046
GSE45670 ITGA9 3680 227297_at -2.6472 0.0000
GSE53622 ITGA9 3680 60819 -1.6088 0.0000
GSE53624 ITGA9 3680 60819 -1.1195 0.0000
GSE63941 ITGA9 3680 206009_at 0.0121 0.9634
GSE77861 ITGA9 3680 206009_at -0.0972 0.6005
GSE97050 ITGA9 3680 A_23_P252193 -1.0574 0.0844
SRP007169 ITGA9 3680 RNAseq 1.2508 0.0131
SRP008496 ITGA9 3680 RNAseq 1.9389 0.0001
SRP064894 ITGA9 3680 RNAseq -1.1216 0.0012
SRP133303 ITGA9 3680 RNAseq -0.9795 0.0374
SRP159526 ITGA9 3680 RNAseq -0.0600 0.9320
SRP193095 ITGA9 3680 RNAseq -0.0366 0.8767
SRP219564 ITGA9 3680 RNAseq -1.0980 0.1970
TCGA ITGA9 3680 RNAseq -1.0276 0.0001

Upregulated datasets: 2; Downregulated datasets: 5.  


 

Survival by ITGA9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ITGA9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGA9 3680 0 19 11
GSE20123 ITGA9 3680 0 19 11
GSE43470 ITGA9 3680 0 20 23
GSE46452 ITGA9 3680 2 17 40
GSE47630 ITGA9 3680 1 25 14
GSE54993 ITGA9 3680 6 3 61
GSE54994 ITGA9 3680 1 32 20
GSE60625 ITGA9 3680 5 0 6
GSE74703 ITGA9 3680 0 16 20
GSE74704 ITGA9 3680 0 13 7
TCGA ITGA9 3680 0 72 24

Total number of gains: 15; Total number of losses: 236; Total Number of normals: 237.  


 

Somatic mutations of ITGA9:

 

Generating mutation plots.

 

Highly correlated genes for ITGA9:

 

Showing top 20/1222 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGA9MSRB30.854613505
ITGA9MAMDC20.852152505
ITGA9SYNPO20.845464606
ITGA9NEGR10.83268505
ITGA9NEXN0.831365606
ITGA9UBXN100.829079303
ITGA9C1QTNF70.828933505
ITGA9MRVI10.822495605
ITGA9MACROD20.820651303
ITGA9TIMP30.81308303
ITGA9CACNB20.805349606
ITGA9EIF4E30.801119505
ITGA9CYP4V20.799469303
ITGA9RNF1500.796451606
ITGA9LRFN50.794976404
ITGA9CLEC3B0.791719303
ITGA9TNFSF120.791277303
ITGA9MAGI2-AS30.786319404
ITGA9FBXL30.782467303
ITGA9FHL10.779562706

For details and further investigation, click here