| Full name: zinc finger and BTB domain containing 16 | Alias Symbol: PLZF | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 7704 | HGNC ID: HGNC:12930 | Ensembl Gene: ENSG00000109906 | OMIM ID: 176797 |
| Drug and gene relationship at DGIdb | |||
ZBTB16 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of ZBTB16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZBTB16 | 7704 | 205883_at | -2.0924 | 0.1406 | |
| GSE20347 | ZBTB16 | 7704 | 205883_at | -0.4268 | 0.0294 | |
| GSE23400 | ZBTB16 | 7704 | 205883_at | -0.9809 | 0.0000 | |
| GSE26886 | ZBTB16 | 7704 | 205883_at | 0.4803 | 0.1005 | |
| GSE29001 | ZBTB16 | 7704 | 205883_at | -0.5788 | 0.0573 | |
| GSE38129 | ZBTB16 | 7704 | 205883_at | -1.6239 | 0.0001 | |
| GSE45670 | ZBTB16 | 7704 | 205883_at | -2.4082 | 0.0000 | |
| GSE53622 | ZBTB16 | 7704 | 11263 | -0.8417 | 0.0000 | |
| GSE53624 | ZBTB16 | 7704 | 11263 | -0.6607 | 0.0000 | |
| GSE63941 | ZBTB16 | 7704 | 205883_at | 0.0957 | 0.5934 | |
| GSE77861 | ZBTB16 | 7704 | 205883_at | -0.0763 | 0.4388 | |
| GSE97050 | ZBTB16 | 7704 | A_23_P104804 | -0.5559 | 0.1450 | |
| SRP064894 | ZBTB16 | 7704 | RNAseq | -1.2666 | 0.0406 | |
| SRP133303 | ZBTB16 | 7704 | RNAseq | -2.8999 | 0.0003 | |
| SRP159526 | ZBTB16 | 7704 | RNAseq | -2.2436 | 0.0002 | |
| SRP219564 | ZBTB16 | 7704 | RNAseq | -0.2465 | 0.7643 | |
| TCGA | ZBTB16 | 7704 | RNAseq | -2.1258 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ZBTB16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZBTB16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZBTB16 | 7704 | 0 | 13 | 17 | |
| GSE20123 | ZBTB16 | 7704 | 0 | 13 | 17 | |
| GSE43470 | ZBTB16 | 7704 | 2 | 7 | 34 | |
| GSE46452 | ZBTB16 | 7704 | 3 | 26 | 30 | |
| GSE47630 | ZBTB16 | 7704 | 2 | 19 | 19 | |
| GSE54993 | ZBTB16 | 7704 | 10 | 0 | 60 | |
| GSE54994 | ZBTB16 | 7704 | 5 | 19 | 29 | |
| GSE60625 | ZBTB16 | 7704 | 0 | 3 | 8 | |
| GSE74703 | ZBTB16 | 7704 | 1 | 5 | 30 | |
| GSE74704 | ZBTB16 | 7704 | 0 | 9 | 11 | |
| TCGA | ZBTB16 | 7704 | 6 | 49 | 41 |
Total number of gains: 29; Total number of losses: 163; Total Number of normals: 296.
Somatic mutations of ZBTB16:
Generating mutation plots.
Highly correlated genes for ZBTB16:
Showing top 20/992 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZBTB16 | RECK | 0.833675 | 3 | 0 | 3 |
| ZBTB16 | ANAPC16 | 0.827933 | 3 | 0 | 3 |
| ZBTB16 | EIF4E3 | 0.809855 | 4 | 0 | 4 |
| ZBTB16 | ADAMTS9-AS2 | 0.802132 | 3 | 0 | 3 |
| ZBTB16 | FBXL3 | 0.795889 | 3 | 0 | 3 |
| ZBTB16 | FILIP1 | 0.794169 | 4 | 0 | 4 |
| ZBTB16 | GPIHBP1 | 0.786922 | 3 | 0 | 3 |
| ZBTB16 | KCNT2 | 0.785187 | 4 | 0 | 4 |
| ZBTB16 | TCF21 | 0.783355 | 8 | 0 | 8 |
| ZBTB16 | SVEP1 | 0.780623 | 5 | 0 | 5 |
| ZBTB16 | CHRDL1 | 0.7774 | 9 | 0 | 8 |
| ZBTB16 | ADAD2 | 0.776267 | 3 | 0 | 3 |
| ZBTB16 | C3orf70 | 0.774642 | 5 | 0 | 5 |
| ZBTB16 | SLC8A1 | 0.768165 | 3 | 0 | 3 |
| ZBTB16 | MAP1LC3A | 0.765959 | 3 | 0 | 3 |
| ZBTB16 | NR3C2 | 0.758423 | 8 | 0 | 7 |
| ZBTB16 | FHL5 | 0.757889 | 7 | 0 | 6 |
| ZBTB16 | TCEAL1 | 0.754293 | 6 | 0 | 6 |
| ZBTB16 | MTURN | 0.751937 | 3 | 0 | 3 |
| ZBTB16 | PDZRN4 | 0.748614 | 8 | 0 | 8 |
For details and further investigation, click here
