GNAQ

 

Full name: G protein subunit alpha q Alias Symbol: G-ALPHA-q|GAQ
Type: protein-coding gene Cytoband: 9q21.2
Entrez ID: 2776 HGNC ID: HGNC:4390 Ensembl Gene: ENSG00000156052 OMIM ID: 600998
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 22/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

GNAQ involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of GNAQ:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNAQ 2776 202615_at -0.5919 0.1054
GSE20347 GNAQ 2776 202615_at -0.6517 0.0000
GSE23400 GNAQ 2776 202615_at -0.3285 0.0000
GSE26886 GNAQ 2776 202615_at -1.1142 0.0000
GSE29001 GNAQ 2776 202615_at -0.5445 0.0116
GSE38129 GNAQ 2776 202615_at -0.7953 0.0000
GSE45670 GNAQ 2776 202615_at -0.8401 0.0000
GSE53622 GNAQ 2776 143376 -0.7697 0.0000
GSE53624 GNAQ 2776 143376 -0.6971 0.0000
GSE63941 GNAQ 2776 202615_at -0.8741 0.0686
GSE77861 GNAQ 2776 202615_at -0.2434 0.1150
GSE97050 GNAQ 2776 A_33_P3343155 -0.6302 0.1049
SRP007169 GNAQ 2776 RNAseq -0.7902 0.1121
SRP008496 GNAQ 2776 RNAseq -0.7823 0.0014
SRP064894 GNAQ 2776 RNAseq -0.5463 0.0041
SRP133303 GNAQ 2776 RNAseq -0.6110 0.0004
SRP159526 GNAQ 2776 RNAseq -0.7443 0.0003
SRP193095 GNAQ 2776 RNAseq -0.7433 0.0000
SRP219564 GNAQ 2776 RNAseq -0.7669 0.0756
TCGA GNAQ 2776 RNAseq -0.3053 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by GNAQ expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNAQ:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNAQ 2776 5 10 15
GSE20123 GNAQ 2776 5 10 15
GSE43470 GNAQ 2776 6 5 32
GSE46452 GNAQ 2776 6 14 39
GSE47630 GNAQ 2776 1 18 21
GSE54993 GNAQ 2776 4 2 64
GSE54994 GNAQ 2776 4 12 37
GSE60625 GNAQ 2776 0 0 11
GSE74703 GNAQ 2776 5 4 27
GSE74704 GNAQ 2776 3 7 10
TCGA GNAQ 2776 18 29 49

Total number of gains: 57; Total number of losses: 111; Total Number of normals: 320.  

 

Somatic mutations of GNAQ:

 

Generating mutation plots.

 

Highly correlated genes for GNAQ:

 

Showing top 20/1417 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNAQFAM120AOS0.808397303
GNAQSLC25A270.801581303
GNAQLETMD10.797239303
GNAQLRFN50.766771303
GNAQANGPTL10.760893504
GNAQFPGT0.753769303
GNAQALDH1A20.749847303
GNAQRHBDF10.739753404
GNAQMACROD20.738023404
GNAQPREX20.731946303
GNAQTHAP20.728207303
GNAQRASSF30.717069505
GNAQGGA30.715778303
GNAQEIF4E30.715282705
GNAQPARP160.714912404
GNAQID40.713116909
GNAQSCARB20.71306303
GNAQPARD3B0.710138403
GNAQRBM200.706719505
GNAQDOCK10.705705403

For details and further investigation, click here