| Full name: transforming growth factor beta receptor 3 | Alias Symbol: betaglycan|BGCAN | ||
| Type: protein-coding gene | Cytoband: 1p22.1 | ||
| Entrez ID: 7049 | HGNC ID: HGNC:11774 | Ensembl Gene: ENSG00000069702 | OMIM ID: 600742 |
| Drug and gene relationship at DGIdb | |||
Expression of TGFBR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TGFBR3 | 7049 | 226625_at | -2.1011 | 0.0624 | |
| GSE20347 | TGFBR3 | 7049 | 204731_at | -1.2183 | 0.0012 | |
| GSE23400 | TGFBR3 | 7049 | 204731_at | -1.2781 | 0.0000 | |
| GSE26886 | TGFBR3 | 7049 | 226625_at | 0.0753 | 0.8526 | |
| GSE29001 | TGFBR3 | 7049 | 204731_at | -1.4772 | 0.0005 | |
| GSE38129 | TGFBR3 | 7049 | 204731_at | -1.8253 | 0.0000 | |
| GSE45670 | TGFBR3 | 7049 | 226625_at | -3.0128 | 0.0000 | |
| GSE53622 | TGFBR3 | 7049 | 89272 | -2.5506 | 0.0000 | |
| GSE53624 | TGFBR3 | 7049 | 22421 | -2.3384 | 0.0000 | |
| GSE63941 | TGFBR3 | 7049 | 226625_at | -2.7373 | 0.0361 | |
| GSE77861 | TGFBR3 | 7049 | 226625_at | 0.1750 | 0.6960 | |
| GSE97050 | TGFBR3 | 7049 | A_23_P200780 | -2.1327 | 0.0465 | |
| SRP007169 | TGFBR3 | 7049 | RNAseq | 0.5820 | 0.2198 | |
| SRP064894 | TGFBR3 | 7049 | RNAseq | -1.6393 | 0.0003 | |
| SRP133303 | TGFBR3 | 7049 | RNAseq | -1.8497 | 0.0003 | |
| SRP159526 | TGFBR3 | 7049 | RNAseq | -1.8575 | 0.0000 | |
| SRP193095 | TGFBR3 | 7049 | RNAseq | -0.7092 | 0.0159 | |
| SRP219564 | TGFBR3 | 7049 | RNAseq | -0.7794 | 0.4452 | |
| TCGA | TGFBR3 | 7049 | RNAseq | -0.8447 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by TGFBR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TGFBR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TGFBR3 | 7049 | 0 | 8 | 22 | |
| GSE20123 | TGFBR3 | 7049 | 0 | 8 | 22 | |
| GSE43470 | TGFBR3 | 7049 | 2 | 5 | 36 | |
| GSE46452 | TGFBR3 | 7049 | 1 | 1 | 57 | |
| GSE47630 | TGFBR3 | 7049 | 8 | 5 | 27 | |
| GSE54993 | TGFBR3 | 7049 | 0 | 1 | 69 | |
| GSE54994 | TGFBR3 | 7049 | 6 | 6 | 41 | |
| GSE60625 | TGFBR3 | 7049 | 0 | 0 | 11 | |
| GSE74703 | TGFBR3 | 7049 | 1 | 4 | 31 | |
| GSE74704 | TGFBR3 | 7049 | 0 | 5 | 15 | |
| TCGA | TGFBR3 | 7049 | 6 | 24 | 66 |
Total number of gains: 24; Total number of losses: 67; Total Number of normals: 397.
Somatic mutations of TGFBR3:
Generating mutation plots.
Highly correlated genes for TGFBR3:
Showing top 20/1396 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TGFBR3 | CLEC3B | 0.881561 | 3 | 0 | 3 |
| TGFBR3 | KCNB1 | 0.868028 | 4 | 0 | 4 |
| TGFBR3 | CYP21A2 | 0.846339 | 3 | 0 | 3 |
| TGFBR3 | XKR4 | 0.831348 | 5 | 0 | 5 |
| TGFBR3 | ANGPTL1 | 0.821346 | 6 | 0 | 5 |
| TGFBR3 | RAB9B | 0.805764 | 6 | 0 | 6 |
| TGFBR3 | FBXL3 | 0.802228 | 3 | 0 | 3 |
| TGFBR3 | GFRA1 | 0.799689 | 6 | 0 | 6 |
| TGFBR3 | PREX2 | 0.79737 | 4 | 0 | 4 |
| TGFBR3 | SLC2A12 | 0.795331 | 3 | 0 | 3 |
| TGFBR3 | SLMAP | 0.783804 | 5 | 0 | 5 |
| TGFBR3 | SYNPO2 | 0.774442 | 7 | 0 | 6 |
| TGFBR3 | HLF | 0.772438 | 10 | 0 | 9 |
| TGFBR3 | DAAM2 | 0.769496 | 6 | 0 | 6 |
| TGFBR3 | LONRF2 | 0.767487 | 5 | 0 | 4 |
| TGFBR3 | PPP1R12B | 0.766551 | 10 | 0 | 9 |
| TGFBR3 | PRELP | 0.762534 | 7 | 0 | 7 |
| TGFBR3 | GPIHBP1 | 0.761385 | 3 | 0 | 3 |
| TGFBR3 | ZNF407 | 0.758957 | 3 | 0 | 3 |
| TGFBR3 | FENDRR | 0.758152 | 5 | 0 | 5 |
For details and further investigation, click here
