| Full name: cytochrome P450 family 2 subfamily A member 6 | Alias Symbol: CPA6|CYP2A | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 1548 | HGNC ID: HGNC:2610 | Ensembl Gene: ENSG00000255974 | OMIM ID: 122720 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2A6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2A6 | 1548 | 207244_x_at | -0.0749 | 0.7326 | |
| GSE20347 | CYP2A6 | 1548 | 207244_x_at | -0.1176 | 0.1915 | |
| GSE23400 | CYP2A6 | 1548 | 1494_f_at | -0.1750 | 0.0000 | |
| GSE26886 | CYP2A6 | 1548 | 207244_x_at | -0.0989 | 0.2916 | |
| GSE29001 | CYP2A6 | 1548 | 211295_x_at | -0.1758 | 0.2635 | |
| GSE38129 | CYP2A6 | 1548 | 207244_x_at | -0.2356 | 0.0194 | |
| GSE45670 | CYP2A6 | 1548 | 207244_x_at | -0.1003 | 0.2479 | |
| GSE53622 | CYP2A6 | 1548 | 40924 | 0.1097 | 0.3630 | |
| GSE53624 | CYP2A6 | 1548 | 40924 | 0.3329 | 0.0035 | |
| GSE63941 | CYP2A6 | 1548 | 207244_x_at | 0.1548 | 0.2931 | |
| GSE77861 | CYP2A6 | 1548 | 207244_x_at | -0.2111 | 0.0923 | |
| SRP133303 | CYP2A6 | 1548 | RNAseq | 0.4760 | 0.1672 | |
| TCGA | CYP2A6 | 1548 | RNAseq | 0.1555 | 0.8693 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP2A6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2A6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2A6 | 1548 | 4 | 5 | 21 | |
| GSE20123 | CYP2A6 | 1548 | 4 | 4 | 22 | |
| GSE43470 | CYP2A6 | 1548 | 3 | 11 | 29 | |
| GSE46452 | CYP2A6 | 1548 | 48 | 1 | 10 | |
| GSE47630 | CYP2A6 | 1548 | 9 | 5 | 26 | |
| GSE54993 | CYP2A6 | 1548 | 17 | 4 | 49 | |
| GSE54994 | CYP2A6 | 1548 | 7 | 10 | 36 | |
| GSE60625 | CYP2A6 | 1548 | 9 | 0 | 2 | |
| GSE74703 | CYP2A6 | 1548 | 3 | 7 | 26 | |
| GSE74704 | CYP2A6 | 1548 | 4 | 2 | 14 | |
| TCGA | CYP2A6 | 1548 | 14 | 16 | 66 |
Total number of gains: 122; Total number of losses: 65; Total Number of normals: 301.
Somatic mutations of CYP2A6:
Generating mutation plots.
Highly correlated genes for CYP2A6:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2A6 | PHLDB1 | 0.736617 | 6 | 0 | 6 |
| CYP2A6 | CCDC87 | 0.717425 | 4 | 0 | 4 |
| CYP2A6 | HEYL | 0.714462 | 6 | 0 | 6 |
| CYP2A6 | ECE2 | 0.712286 | 5 | 0 | 5 |
| CYP2A6 | IGH | 0.702854 | 6 | 0 | 5 |
| CYP2A6 | PSG1 | 0.701978 | 6 | 0 | 5 |
| CYP2A6 | FRMPD4 | 0.700043 | 4 | 0 | 3 |
| CYP2A6 | FSHR | 0.699904 | 4 | 0 | 4 |
| CYP2A6 | PTPRN2 | 0.698064 | 4 | 0 | 4 |
| CYP2A6 | GDF5 | 0.698021 | 4 | 0 | 4 |
| CYP2A6 | ASIP | 0.695809 | 3 | 0 | 3 |
| CYP2A6 | UBE2D4 | 0.695646 | 3 | 0 | 3 |
| CYP2A6 | GAS8 | 0.695013 | 6 | 0 | 6 |
| CYP2A6 | SLC18A1 | 0.692551 | 6 | 0 | 5 |
| CYP2A6 | UNC5B | 0.691411 | 4 | 0 | 3 |
| CYP2A6 | RORC | 0.691082 | 6 | 0 | 6 |
| CYP2A6 | CEACAM3 | 0.691082 | 5 | 0 | 4 |
| CYP2A6 | KLF1 | 0.689966 | 4 | 0 | 4 |
| CYP2A6 | ACSL6 | 0.689936 | 3 | 0 | 3 |
| CYP2A6 | CIITA | 0.688018 | 5 | 0 | 4 |
For details and further investigation, click here
