| Full name: solute carrier family 2 member 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 6517 | HGNC ID: HGNC:11009 | Ensembl Gene: ENSG00000181856 | OMIM ID: 138190 |
| Drug and gene relationship at DGIdb | |||
SLC2A4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of SLC2A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC2A4 | 6517 | 206603_at | 0.0201 | 0.9497 | |
| GSE20347 | SLC2A4 | 6517 | 206603_at | -0.0319 | 0.6477 | |
| GSE23400 | SLC2A4 | 6517 | 206603_at | -0.0892 | 0.0000 | |
| GSE26886 | SLC2A4 | 6517 | 206603_at | -0.0493 | 0.6197 | |
| GSE29001 | SLC2A4 | 6517 | 206603_at | 0.0072 | 0.9672 | |
| GSE38129 | SLC2A4 | 6517 | 206603_at | -0.1865 | 0.0031 | |
| GSE45670 | SLC2A4 | 6517 | 206603_at | -0.0746 | 0.5584 | |
| GSE53622 | SLC2A4 | 6517 | 72870 | -2.8126 | 0.0000 | |
| GSE53624 | SLC2A4 | 6517 | 12064 | -1.5243 | 0.0000 | |
| GSE63941 | SLC2A4 | 6517 | 206603_at | -0.0425 | 0.7025 | |
| GSE77861 | SLC2A4 | 6517 | 206603_at | -0.1459 | 0.1076 | |
| GSE97050 | SLC2A4 | 6517 | A_32_P151263 | -2.3307 | 0.0866 | |
| SRP007169 | SLC2A4 | 6517 | RNAseq | -0.0708 | 0.9232 | |
| SRP064894 | SLC2A4 | 6517 | RNAseq | -1.1657 | 0.0091 | |
| SRP133303 | SLC2A4 | 6517 | RNAseq | -1.0099 | 0.1304 | |
| SRP159526 | SLC2A4 | 6517 | RNAseq | -1.3294 | 0.0647 | |
| SRP193095 | SLC2A4 | 6517 | RNAseq | -0.4567 | 0.0171 | |
| SRP219564 | SLC2A4 | 6517 | RNAseq | -1.2220 | 0.2703 | |
| TCGA | SLC2A4 | 6517 | RNAseq | -1.4537 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SLC2A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC2A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC2A4 | 6517 | 4 | 2 | 24 | |
| GSE20123 | SLC2A4 | 6517 | 4 | 3 | 23 | |
| GSE43470 | SLC2A4 | 6517 | 1 | 4 | 38 | |
| GSE46452 | SLC2A4 | 6517 | 34 | 1 | 24 | |
| GSE47630 | SLC2A4 | 6517 | 7 | 1 | 32 | |
| GSE54993 | SLC2A4 | 6517 | 4 | 3 | 63 | |
| GSE54994 | SLC2A4 | 6517 | 5 | 8 | 40 | |
| GSE60625 | SLC2A4 | 6517 | 4 | 0 | 7 | |
| GSE74703 | SLC2A4 | 6517 | 1 | 2 | 33 | |
| GSE74704 | SLC2A4 | 6517 | 2 | 1 | 17 | |
| TCGA | SLC2A4 | 6517 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of SLC2A4:
Generating mutation plots.
Highly correlated genes for SLC2A4:
Showing top 20/1057 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC2A4 | ASB5 | 0.863983 | 3 | 0 | 3 |
| SLC2A4 | CLEC3B | 0.851484 | 3 | 0 | 3 |
| SLC2A4 | SLMAP | 0.845073 | 3 | 0 | 3 |
| SLC2A4 | CYP21A2 | 0.836502 | 3 | 0 | 3 |
| SLC2A4 | VMAC | 0.800252 | 3 | 0 | 3 |
| SLC2A4 | XKR4 | 0.799007 | 4 | 0 | 4 |
| SLC2A4 | SORCS1 | 0.776413 | 4 | 0 | 4 |
| SLC2A4 | OGN | 0.771711 | 4 | 0 | 4 |
| SLC2A4 | MYOCD | 0.770886 | 4 | 0 | 3 |
| SLC2A4 | RBPMS2 | 0.768425 | 4 | 0 | 4 |
| SLC2A4 | ANGPTL1 | 0.765642 | 4 | 0 | 3 |
| SLC2A4 | SYNPO2 | 0.763152 | 4 | 0 | 3 |
| SLC2A4 | MRVI1 | 0.752606 | 4 | 0 | 3 |
| SLC2A4 | ACTBL2 | 0.752251 | 3 | 0 | 3 |
| SLC2A4 | SH3D19 | 0.746845 | 3 | 0 | 3 |
| SLC2A4 | RAB9B | 0.744372 | 4 | 0 | 3 |
| SLC2A4 | PTCHD1 | 0.741681 | 3 | 0 | 3 |
| SLC2A4 | AMIGO1 | 0.740879 | 3 | 0 | 3 |
| SLC2A4 | CCL14 | 0.740679 | 3 | 0 | 3 |
| SLC2A4 | PPP1R12C | 0.739713 | 3 | 0 | 3 |
For details and further investigation, click here
