| Full name: NBR1 autophagy cargo receptor | Alias Symbol: CA125|KIAA0049|1A1-3B | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 4077 | HGNC ID: HGNC:6746 | Ensembl Gene: ENSG00000188554 | OMIM ID: 166945 |
| Drug and gene relationship at DGIdb | |||
Expression of NBR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NBR1 | 4077 | 201384_s_at | -0.2386 | 0.4221 | |
| GSE20347 | NBR1 | 4077 | 201384_s_at | -0.2508 | 0.0613 | |
| GSE23400 | NBR1 | 4077 | 201384_s_at | -0.0587 | 0.3903 | |
| GSE26886 | NBR1 | 4077 | 201384_s_at | -0.5230 | 0.0949 | |
| GSE29001 | NBR1 | 4077 | 201384_s_at | -0.2226 | 0.4350 | |
| GSE38129 | NBR1 | 4077 | 201384_s_at | -0.2356 | 0.0955 | |
| GSE45670 | NBR1 | 4077 | 201384_s_at | -0.2546 | 0.0263 | |
| GSE53622 | NBR1 | 4077 | 126842 | -0.2394 | 0.0001 | |
| GSE53624 | NBR1 | 4077 | 126842 | -0.2364 | 0.0001 | |
| GSE63941 | NBR1 | 4077 | 201384_s_at | -1.0230 | 0.0020 | |
| GSE77861 | NBR1 | 4077 | 201384_s_at | 0.1536 | 0.6996 | |
| GSE97050 | NBR1 | 4077 | A_23_P207399 | -0.2979 | 0.2110 | |
| SRP007169 | NBR1 | 4077 | RNAseq | 0.2022 | 0.6583 | |
| SRP008496 | NBR1 | 4077 | RNAseq | 0.2672 | 0.2609 | |
| SRP064894 | NBR1 | 4077 | RNAseq | -0.4375 | 0.0014 | |
| SRP133303 | NBR1 | 4077 | RNAseq | -0.2118 | 0.1058 | |
| SRP159526 | NBR1 | 4077 | RNAseq | -0.2702 | 0.3639 | |
| SRP193095 | NBR1 | 4077 | RNAseq | -0.5172 | 0.0000 | |
| SRP219564 | NBR1 | 4077 | RNAseq | -0.3915 | 0.0983 | |
| TCGA | NBR1 | 4077 | RNAseq | -0.1254 | 0.0020 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NBR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NBR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NBR1 | 4077 | 6 | 2 | 22 | |
| GSE20123 | NBR1 | 4077 | 6 | 2 | 22 | |
| GSE43470 | NBR1 | 4077 | 1 | 2 | 40 | |
| GSE46452 | NBR1 | 4077 | 34 | 0 | 25 | |
| GSE47630 | NBR1 | 4077 | 8 | 1 | 31 | |
| GSE54993 | NBR1 | 4077 | 3 | 4 | 63 | |
| GSE54994 | NBR1 | 4077 | 8 | 5 | 40 | |
| GSE60625 | NBR1 | 4077 | 4 | 0 | 7 | |
| GSE74703 | NBR1 | 4077 | 1 | 1 | 34 | |
| GSE74704 | NBR1 | 4077 | 4 | 1 | 15 | |
| TCGA | NBR1 | 4077 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of NBR1:
Generating mutation plots.
Highly correlated genes for NBR1:
Showing top 20/763 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NBR1 | ANTXR2 | 0.814041 | 3 | 0 | 3 |
| NBR1 | ANO6 | 0.809 | 3 | 0 | 3 |
| NBR1 | ZNF547 | 0.806077 | 3 | 0 | 3 |
| NBR1 | FKBP7 | 0.794997 | 4 | 0 | 4 |
| NBR1 | ANKHD1 | 0.772423 | 3 | 0 | 3 |
| NBR1 | DPY19L3 | 0.76659 | 3 | 0 | 3 |
| NBR1 | RHBDF1 | 0.763856 | 3 | 0 | 3 |
| NBR1 | ZNF564 | 0.755433 | 3 | 0 | 3 |
| NBR1 | NR2C2 | 0.754695 | 3 | 0 | 3 |
| NBR1 | C20orf194 | 0.753964 | 3 | 0 | 3 |
| NBR1 | SNX18 | 0.752901 | 3 | 0 | 3 |
| NBR1 | MGAT5 | 0.746114 | 3 | 0 | 3 |
| NBR1 | TBC1D28 | 0.743373 | 3 | 0 | 3 |
| NBR1 | CSNK1A1 | 0.736047 | 3 | 0 | 3 |
| NBR1 | RSAD2 | 0.734186 | 3 | 0 | 3 |
| NBR1 | UBE4B | 0.733997 | 4 | 0 | 4 |
| NBR1 | CDC42EP3 | 0.728104 | 4 | 0 | 4 |
| NBR1 | DHDDS | 0.725479 | 3 | 0 | 3 |
| NBR1 | AFAP1 | 0.72344 | 3 | 0 | 3 |
| NBR1 | PBX2 | 0.721129 | 3 | 0 | 3 |
For details and further investigation, click here
