| Full name: actin filament associated protein 1 | Alias Symbol: AFAP-110|AFAP | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 60312 | HGNC ID: HGNC:24017 | Ensembl Gene: ENSG00000196526 | OMIM ID: 608252 |
| Drug and gene relationship at DGIdb | |||
Expression of AFAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFAP1 | 60312 | 203563_at | 0.2842 | 0.2071 | |
| GSE20347 | AFAP1 | 60312 | 203563_at | 0.1202 | 0.1984 | |
| GSE23400 | AFAP1 | 60312 | 203563_at | 0.0393 | 0.1605 | |
| GSE26886 | AFAP1 | 60312 | 203563_at | 0.5428 | 0.0044 | |
| GSE29001 | AFAP1 | 60312 | 203563_at | 0.3638 | 0.0459 | |
| GSE38129 | AFAP1 | 60312 | 203563_at | 0.0245 | 0.8890 | |
| GSE45670 | AFAP1 | 60312 | 203563_at | -0.2312 | 0.3799 | |
| GSE53622 | AFAP1 | 60312 | 29573 | 0.5386 | 0.0000 | |
| GSE53624 | AFAP1 | 60312 | 29573 | 0.5178 | 0.0000 | |
| GSE63941 | AFAP1 | 60312 | 203563_at | -1.7638 | 0.0049 | |
| GSE77861 | AFAP1 | 60312 | 203563_at | 0.2303 | 0.1506 | |
| GSE97050 | AFAP1 | 60312 | A_23_P72387 | -0.0712 | 0.8362 | |
| SRP007169 | AFAP1 | 60312 | RNAseq | 2.1688 | 0.0000 | |
| SRP008496 | AFAP1 | 60312 | RNAseq | 2.3325 | 0.0000 | |
| SRP064894 | AFAP1 | 60312 | RNAseq | 0.4030 | 0.0911 | |
| SRP133303 | AFAP1 | 60312 | RNAseq | 0.6700 | 0.0042 | |
| SRP159526 | AFAP1 | 60312 | RNAseq | 0.2932 | 0.4424 | |
| SRP193095 | AFAP1 | 60312 | RNAseq | 0.9763 | 0.0000 | |
| SRP219564 | AFAP1 | 60312 | RNAseq | 0.1569 | 0.7658 | |
| TCGA | AFAP1 | 60312 | RNAseq | -0.0496 | 0.3994 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by AFAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AFAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFAP1 | 60312 | 0 | 18 | 12 | |
| GSE20123 | AFAP1 | 60312 | 0 | 18 | 12 | |
| GSE43470 | AFAP1 | 60312 | 0 | 17 | 26 | |
| GSE46452 | AFAP1 | 60312 | 1 | 36 | 22 | |
| GSE47630 | AFAP1 | 60312 | 1 | 19 | 20 | |
| GSE54993 | AFAP1 | 60312 | 10 | 0 | 60 | |
| GSE54994 | AFAP1 | 60312 | 3 | 12 | 38 | |
| GSE60625 | AFAP1 | 60312 | 0 | 0 | 11 | |
| GSE74703 | AFAP1 | 60312 | 0 | 13 | 23 | |
| GSE74704 | AFAP1 | 60312 | 0 | 10 | 10 | |
| TCGA | AFAP1 | 60312 | 8 | 47 | 41 |
Total number of gains: 23; Total number of losses: 190; Total Number of normals: 275.
Somatic mutations of AFAP1:
Generating mutation plots.
Highly correlated genes for AFAP1:
Showing top 20/1097 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFAP1 | PIGC | 0.808342 | 4 | 0 | 4 |
| AFAP1 | RRAGB | 0.756204 | 3 | 0 | 3 |
| AFAP1 | SLC39A3 | 0.742741 | 3 | 0 | 3 |
| AFAP1 | PCGF3 | 0.737736 | 3 | 0 | 3 |
| AFAP1 | ADAM9 | 0.725848 | 3 | 0 | 3 |
| AFAP1 | MSRB2 | 0.724937 | 3 | 0 | 3 |
| AFAP1 | NBR1 | 0.72344 | 3 | 0 | 3 |
| AFAP1 | ATP10A | 0.722721 | 5 | 0 | 5 |
| AFAP1 | FKBP7 | 0.714021 | 6 | 0 | 5 |
| AFAP1 | DGCR2 | 0.710185 | 3 | 0 | 3 |
| AFAP1 | KRTCAP2 | 0.70979 | 4 | 0 | 4 |
| AFAP1 | PDCD2L | 0.706848 | 3 | 0 | 3 |
| AFAP1 | PODN | 0.705395 | 3 | 0 | 3 |
| AFAP1 | RAB34 | 0.699252 | 3 | 0 | 3 |
| AFAP1 | CLCN7 | 0.697807 | 3 | 0 | 3 |
| AFAP1 | TMTC4 | 0.69726 | 4 | 0 | 4 |
| AFAP1 | GOLGA3 | 0.697246 | 4 | 0 | 4 |
| AFAP1 | CCDC18 | 0.69626 | 3 | 0 | 3 |
| AFAP1 | TOMM40L | 0.696071 | 3 | 0 | 3 |
| AFAP1 | SLC37A3 | 0.695113 | 5 | 0 | 4 |
For details and further investigation, click here
