| Full name: PBX homeobox 2 | Alias Symbol: G17|HOX12|PBX2MHC | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 5089 | HGNC ID: HGNC:8633 | Ensembl Gene: ENSG00000204304 | OMIM ID: 176311 |
| Drug and gene relationship at DGIdb | |||
Expression of PBX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PBX2 | 5089 | 202876_s_at | -0.0155 | 0.9732 | |
| GSE20347 | PBX2 | 5089 | 202876_s_at | -0.1933 | 0.0527 | |
| GSE23400 | PBX2 | 5089 | 202876_s_at | -0.1255 | 0.0998 | |
| GSE26886 | PBX2 | 5089 | 202876_s_at | -0.3862 | 0.1157 | |
| GSE29001 | PBX2 | 5089 | 202876_s_at | 0.0155 | 0.9686 | |
| GSE38129 | PBX2 | 5089 | 202876_s_at | -0.1598 | 0.4156 | |
| GSE45670 | PBX2 | 5089 | 202876_s_at | -0.1014 | 0.3756 | |
| GSE53622 | PBX2 | 5089 | 78939 | -0.4442 | 0.0000 | |
| GSE53624 | PBX2 | 5089 | 78939 | -0.3579 | 0.0000 | |
| GSE63941 | PBX2 | 5089 | 202876_s_at | 0.9835 | 0.0685 | |
| GSE77861 | PBX2 | 5089 | 202876_s_at | -0.2882 | 0.0240 | |
| GSE97050 | PBX2 | 5089 | A_23_P214658 | -0.8675 | 0.0781 | |
| SRP007169 | PBX2 | 5089 | RNAseq | -0.6755 | 0.0577 | |
| SRP008496 | PBX2 | 5089 | RNAseq | -0.7265 | 0.0002 | |
| SRP064894 | PBX2 | 5089 | RNAseq | 0.0117 | 0.8993 | |
| SRP133303 | PBX2 | 5089 | RNAseq | -0.3303 | 0.0424 | |
| SRP159526 | PBX2 | 5089 | RNAseq | -0.0983 | 0.6134 | |
| SRP193095 | PBX2 | 5089 | RNAseq | -0.0548 | 0.6442 | |
| SRP219564 | PBX2 | 5089 | RNAseq | -0.1087 | 0.6080 | |
| TCGA | PBX2 | 5089 | RNAseq | -0.0046 | 0.9248 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PBX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PBX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PBX2 | 5089 | 5 | 1 | 24 | |
| GSE20123 | PBX2 | 5089 | 5 | 1 | 24 | |
| GSE43470 | PBX2 | 5089 | 5 | 1 | 37 | |
| GSE46452 | PBX2 | 5089 | 1 | 10 | 48 | |
| GSE47630 | PBX2 | 5089 | 7 | 4 | 29 | |
| GSE54993 | PBX2 | 5089 | 2 | 1 | 67 | |
| GSE54994 | PBX2 | 5089 | 11 | 4 | 38 | |
| GSE60625 | PBX2 | 5089 | 0 | 1 | 10 | |
| GSE74703 | PBX2 | 5089 | 5 | 0 | 31 | |
| GSE74704 | PBX2 | 5089 | 2 | 0 | 18 | |
| TCGA | PBX2 | 5089 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of PBX2:
Generating mutation plots.
Highly correlated genes for PBX2:
Showing top 20/334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PBX2 | PPP1R11 | 0.808462 | 3 | 0 | 3 |
| PBX2 | ZNF614 | 0.781167 | 3 | 0 | 3 |
| PBX2 | FRA10AC1 | 0.77924 | 3 | 0 | 3 |
| PBX2 | ZRANB2 | 0.739269 | 3 | 0 | 3 |
| PBX2 | ELMO1 | 0.73694 | 3 | 0 | 3 |
| PBX2 | KCTD6 | 0.735027 | 4 | 0 | 4 |
| PBX2 | FBXO10 | 0.728007 | 3 | 0 | 3 |
| PBX2 | NBR1 | 0.721129 | 3 | 0 | 3 |
| PBX2 | USP20 | 0.719119 | 4 | 0 | 3 |
| PBX2 | TMCO4 | 0.713693 | 4 | 0 | 3 |
| PBX2 | SETD2 | 0.711631 | 3 | 0 | 3 |
| PBX2 | IFT88 | 0.705871 | 3 | 0 | 3 |
| PBX2 | ZNF436 | 0.70472 | 3 | 0 | 3 |
| PBX2 | ZNF470 | 0.702715 | 4 | 0 | 3 |
| PBX2 | ZNF879 | 0.699083 | 4 | 0 | 4 |
| PBX2 | CWC27 | 0.698523 | 3 | 0 | 3 |
| PBX2 | JADE3 | 0.689477 | 3 | 0 | 3 |
| PBX2 | UBE3B | 0.687729 | 4 | 0 | 4 |
| PBX2 | UFC1 | 0.685806 | 3 | 0 | 3 |
| PBX2 | VRK3 | 0.683682 | 4 | 0 | 3 |
For details and further investigation, click here
