| Full name: rhomboid 5 homolog 1 | Alias Symbol: EGFR-RS|FLJ2235|Dist1|iRhom1 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 64285 | HGNC ID: HGNC:20561 | Ensembl Gene: ENSG00000007384 | OMIM ID: 614403 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RHBDF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RHBDF1 | 64285 | 218686_s_at | -0.4634 | 0.5119 | |
| GSE20347 | RHBDF1 | 64285 | 218686_s_at | -0.8464 | 0.0000 | |
| GSE23400 | RHBDF1 | 64285 | 218686_s_at | -0.2849 | 0.0000 | |
| GSE26886 | RHBDF1 | 64285 | 218686_s_at | -1.4094 | 0.0000 | |
| GSE29001 | RHBDF1 | 64285 | 218686_s_at | -0.4337 | 0.1523 | |
| GSE38129 | RHBDF1 | 64285 | 218686_s_at | -0.6108 | 0.0000 | |
| GSE45670 | RHBDF1 | 64285 | 218686_s_at | -0.1514 | 0.3216 | |
| GSE53622 | RHBDF1 | 64285 | 7876 | 0.0055 | 0.9528 | |
| GSE53624 | RHBDF1 | 64285 | 7876 | -0.1572 | 0.0305 | |
| GSE63941 | RHBDF1 | 64285 | 218686_s_at | -1.2139 | 0.0118 | |
| GSE77861 | RHBDF1 | 64285 | 218686_s_at | -0.4976 | 0.0794 | |
| GSE97050 | RHBDF1 | 64285 | A_23_P163682 | 0.2798 | 0.3001 | |
| SRP007169 | RHBDF1 | 64285 | RNAseq | -1.7152 | 0.0000 | |
| SRP008496 | RHBDF1 | 64285 | RNAseq | -1.1958 | 0.0001 | |
| SRP064894 | RHBDF1 | 64285 | RNAseq | -0.2480 | 0.2021 | |
| SRP133303 | RHBDF1 | 64285 | RNAseq | -0.4607 | 0.0007 | |
| SRP159526 | RHBDF1 | 64285 | RNAseq | -0.5536 | 0.0465 | |
| SRP193095 | RHBDF1 | 64285 | RNAseq | -0.0314 | 0.7873 | |
| SRP219564 | RHBDF1 | 64285 | RNAseq | -0.1265 | 0.7124 | |
| TCGA | RHBDF1 | 64285 | RNAseq | 0.0879 | 0.2117 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RHBDF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RHBDF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RHBDF1 | 64285 | 5 | 5 | 20 | |
| GSE20123 | RHBDF1 | 64285 | 5 | 4 | 21 | |
| GSE43470 | RHBDF1 | 64285 | 3 | 7 | 33 | |
| GSE46452 | RHBDF1 | 64285 | 38 | 1 | 20 | |
| GSE47630 | RHBDF1 | 64285 | 12 | 7 | 21 | |
| GSE54993 | RHBDF1 | 64285 | 3 | 5 | 62 | |
| GSE54994 | RHBDF1 | 64285 | 4 | 10 | 39 | |
| GSE60625 | RHBDF1 | 64285 | 4 | 0 | 7 | |
| GSE74703 | RHBDF1 | 64285 | 3 | 5 | 28 | |
| GSE74704 | RHBDF1 | 64285 | 3 | 2 | 15 | |
| TCGA | RHBDF1 | 64285 | 20 | 15 | 61 |
Total number of gains: 100; Total number of losses: 61; Total Number of normals: 327.
Somatic mutations of RHBDF1:
Generating mutation plots.
Highly correlated genes for RHBDF1:
Showing top 20/1089 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RHBDF1 | CAPN7 | 0.823118 | 3 | 0 | 3 |
| RHBDF1 | PITHD1 | 0.81788 | 3 | 0 | 3 |
| RHBDF1 | HDHD2 | 0.813911 | 3 | 0 | 3 |
| RHBDF1 | KIAA2026 | 0.802993 | 3 | 0 | 3 |
| RHBDF1 | DAPL1 | 0.772646 | 3 | 0 | 3 |
| RHBDF1 | NBR1 | 0.763856 | 3 | 0 | 3 |
| RHBDF1 | COMMD1 | 0.762461 | 3 | 0 | 3 |
| RHBDF1 | MTIF3 | 0.762333 | 3 | 0 | 3 |
| RHBDF1 | CYSRT1 | 0.759483 | 3 | 0 | 3 |
| RHBDF1 | BLOC1S2 | 0.759276 | 3 | 0 | 3 |
| RHBDF1 | NKTR | 0.758733 | 3 | 0 | 3 |
| RHBDF1 | A2ML1 | 0.753349 | 3 | 0 | 3 |
| RHBDF1 | CCNYL1 | 0.75295 | 5 | 0 | 4 |
| RHBDF1 | CEPT1 | 0.750767 | 4 | 0 | 3 |
| RHBDF1 | RABGAP1 | 0.750093 | 3 | 0 | 3 |
| RHBDF1 | GPCPD1 | 0.749233 | 3 | 0 | 3 |
| RHBDF1 | TMEM19 | 0.748383 | 4 | 0 | 4 |
| RHBDF1 | SERPINB1 | 0.746553 | 6 | 0 | 6 |
| RHBDF1 | JDP2 | 0.746387 | 3 | 0 | 3 |
| RHBDF1 | ZFP3 | 0.745592 | 3 | 0 | 3 |
For details and further investigation, click here
