| Full name: dehydrodolichyl diphosphate synthase subunit | Alias Symbol: HDS|FLJ13102|DS|RP59|hCIT | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 79947 | HGNC ID: HGNC:20603 | Ensembl Gene: ENSG00000117682 | OMIM ID: 608172 |
| Drug and gene relationship at DGIdb | |||
Expression of DHDDS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHDDS | 79947 | 218547_at | -0.3098 | 0.4290 | |
| GSE20347 | DHDDS | 79947 | 218547_at | -0.3940 | 0.0001 | |
| GSE23400 | DHDDS | 79947 | 218547_at | -0.2459 | 0.0000 | |
| GSE26886 | DHDDS | 79947 | 218547_at | -0.4533 | 0.0155 | |
| GSE29001 | DHDDS | 79947 | 218547_at | -0.4218 | 0.0695 | |
| GSE38129 | DHDDS | 79947 | 218547_at | -0.3801 | 0.0000 | |
| GSE45670 | DHDDS | 79947 | 218547_at | 0.0218 | 0.9071 | |
| GSE53622 | DHDDS | 79947 | 70849 | -0.4643 | 0.0000 | |
| GSE53624 | DHDDS | 79947 | 70849 | -0.4995 | 0.0000 | |
| GSE63941 | DHDDS | 79947 | 218547_at | -0.8461 | 0.0068 | |
| GSE77861 | DHDDS | 79947 | 218547_at | -0.3662 | 0.0117 | |
| GSE97050 | DHDDS | 79947 | A_33_P3340792 | 0.0441 | 0.8758 | |
| SRP007169 | DHDDS | 79947 | RNAseq | -1.2074 | 0.0017 | |
| SRP008496 | DHDDS | 79947 | RNAseq | -1.3171 | 0.0000 | |
| SRP064894 | DHDDS | 79947 | RNAseq | -0.1769 | 0.1661 | |
| SRP133303 | DHDDS | 79947 | RNAseq | -0.1396 | 0.3507 | |
| SRP159526 | DHDDS | 79947 | RNAseq | -0.6512 | 0.0077 | |
| SRP193095 | DHDDS | 79947 | RNAseq | -0.3602 | 0.0000 | |
| SRP219564 | DHDDS | 79947 | RNAseq | -0.3430 | 0.2731 | |
| TCGA | DHDDS | 79947 | RNAseq | -0.1427 | 0.0049 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DHDDS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHDDS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHDDS | 79947 | 0 | 6 | 24 | |
| GSE20123 | DHDDS | 79947 | 0 | 5 | 25 | |
| GSE43470 | DHDDS | 79947 | 2 | 6 | 35 | |
| GSE46452 | DHDDS | 79947 | 5 | 1 | 53 | |
| GSE47630 | DHDDS | 79947 | 8 | 3 | 29 | |
| GSE54993 | DHDDS | 79947 | 2 | 1 | 67 | |
| GSE54994 | DHDDS | 79947 | 10 | 4 | 39 | |
| GSE60625 | DHDDS | 79947 | 0 | 0 | 11 | |
| GSE74703 | DHDDS | 79947 | 1 | 4 | 31 | |
| GSE74704 | DHDDS | 79947 | 0 | 0 | 20 | |
| TCGA | DHDDS | 79947 | 9 | 24 | 63 |
Total number of gains: 37; Total number of losses: 54; Total Number of normals: 397.
Somatic mutations of DHDDS:
Generating mutation plots.
Highly correlated genes for DHDDS:
Showing top 20/1090 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHDDS | ZFC3H1 | 0.760671 | 4 | 0 | 4 |
| DHDDS | TTC39B | 0.754964 | 3 | 0 | 3 |
| DHDDS | TMEM220 | 0.754257 | 3 | 0 | 3 |
| DHDDS | DPY19L3 | 0.751137 | 3 | 0 | 3 |
| DHDDS | PIGB | 0.746785 | 3 | 0 | 3 |
| DHDDS | STOML1 | 0.733832 | 3 | 0 | 3 |
| DHDDS | PODN | 0.729258 | 3 | 0 | 3 |
| DHDDS | UBQLN1 | 0.72893 | 3 | 0 | 3 |
| DHDDS | NBR1 | 0.725479 | 3 | 0 | 3 |
| DHDDS | ATP8B2 | 0.720986 | 3 | 0 | 3 |
| DHDDS | CCDC12 | 0.715 | 5 | 0 | 5 |
| DHDDS | MAML2 | 0.712989 | 4 | 0 | 4 |
| DHDDS | TMEM8B | 0.707183 | 3 | 0 | 3 |
| DHDDS | ADCY7 | 0.70578 | 3 | 0 | 3 |
| DHDDS | KRT33B | 0.699878 | 3 | 0 | 3 |
| DHDDS | IQCC | 0.697947 | 3 | 0 | 3 |
| DHDDS | GPR108 | 0.69222 | 4 | 0 | 3 |
| DHDDS | CMTR2 | 0.691299 | 3 | 0 | 3 |
| DHDDS | ACY1 | 0.690734 | 3 | 0 | 3 |
| DHDDS | FNBP1 | 0.689295 | 3 | 0 | 3 |
For details and further investigation, click here
