| Full name: NADH:ubiquinone oxidoreductase subunit B3 | Alias Symbol: B12 | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 4709 | HGNC ID: HGNC:7698 | Ensembl Gene: ENSG00000119013 | OMIM ID: 603839 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of NDUFB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDUFB3 | 4709 | 203371_s_at | -0.2403 | 0.4848 | |
| GSE20347 | NDUFB3 | 4709 | 203371_s_at | -0.2505 | 0.0443 | |
| GSE23400 | NDUFB3 | 4709 | 203371_s_at | -0.1815 | 0.0107 | |
| GSE26886 | NDUFB3 | 4709 | 203371_s_at | -0.4610 | 0.0000 | |
| GSE29001 | NDUFB3 | 4709 | 203371_s_at | -0.2933 | 0.0661 | |
| GSE38129 | NDUFB3 | 4709 | 203371_s_at | -0.0184 | 0.9058 | |
| GSE45670 | NDUFB3 | 4709 | 203371_s_at | 0.0824 | 0.5967 | |
| GSE53622 | NDUFB3 | 4709 | 23191 | -0.4762 | 0.0000 | |
| GSE53624 | NDUFB3 | 4709 | 23191 | -0.2592 | 0.0000 | |
| GSE63941 | NDUFB3 | 4709 | 203371_s_at | -0.2690 | 0.5829 | |
| GSE77861 | NDUFB3 | 4709 | 203371_s_at | -0.5146 | 0.0227 | |
| GSE97050 | NDUFB3 | 4709 | A_33_P3413597 | -0.3569 | 0.2525 | |
| SRP007169 | NDUFB3 | 4709 | RNAseq | -1.4652 | 0.0003 | |
| SRP008496 | NDUFB3 | 4709 | RNAseq | -1.2452 | 0.0000 | |
| SRP064894 | NDUFB3 | 4709 | RNAseq | -0.6852 | 0.0008 | |
| SRP133303 | NDUFB3 | 4709 | RNAseq | -0.2086 | 0.1924 | |
| SRP159526 | NDUFB3 | 4709 | RNAseq | -0.5751 | 0.0822 | |
| SRP193095 | NDUFB3 | 4709 | RNAseq | -1.0104 | 0.0000 | |
| SRP219564 | NDUFB3 | 4709 | RNAseq | -0.8832 | 0.0107 | |
| TCGA | NDUFB3 | 4709 | RNAseq | 0.0578 | 0.3131 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by NDUFB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDUFB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDUFB3 | 4709 | 6 | 4 | 20 | |
| GSE20123 | NDUFB3 | 4709 | 6 | 4 | 20 | |
| GSE43470 | NDUFB3 | 4709 | 1 | 1 | 41 | |
| GSE46452 | NDUFB3 | 4709 | 1 | 4 | 54 | |
| GSE47630 | NDUFB3 | 4709 | 4 | 5 | 31 | |
| GSE54993 | NDUFB3 | 4709 | 0 | 3 | 67 | |
| GSE54994 | NDUFB3 | 4709 | 10 | 8 | 35 | |
| GSE60625 | NDUFB3 | 4709 | 0 | 3 | 8 | |
| GSE74703 | NDUFB3 | 4709 | 1 | 1 | 34 | |
| GSE74704 | NDUFB3 | 4709 | 3 | 2 | 15 | |
| TCGA | NDUFB3 | 4709 | 22 | 10 | 64 |
Total number of gains: 54; Total number of losses: 45; Total Number of normals: 389.
Somatic mutations of NDUFB3:
Generating mutation plots.
Highly correlated genes for NDUFB3:
Showing top 20/904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDUFB3 | MAMDC4 | 0.760157 | 3 | 0 | 3 |
| NDUFB3 | ATP6V0D1 | 0.755037 | 3 | 0 | 3 |
| NDUFB3 | MRPL35 | 0.750553 | 3 | 0 | 3 |
| NDUFB3 | TBRG1 | 0.742407 | 3 | 0 | 3 |
| NDUFB3 | NIPSNAP3A | 0.742148 | 5 | 0 | 5 |
| NDUFB3 | XKR6 | 0.73603 | 3 | 0 | 3 |
| NDUFB3 | ZNF585A | 0.731919 | 3 | 0 | 3 |
| NDUFB3 | ABHD14B | 0.731365 | 3 | 0 | 3 |
| NDUFB3 | MTF1 | 0.727022 | 3 | 0 | 3 |
| NDUFB3 | EIF1AY | 0.724908 | 4 | 0 | 3 |
| NDUFB3 | F7 | 0.722589 | 3 | 0 | 3 |
| NDUFB3 | TP53RK | 0.720291 | 3 | 0 | 3 |
| NDUFB3 | HDHD2 | 0.720048 | 4 | 0 | 4 |
| NDUFB3 | FUCA1 | 0.71067 | 3 | 0 | 3 |
| NDUFB3 | HEMK1 | 0.707898 | 4 | 0 | 3 |
| NDUFB3 | CCNDBP1 | 0.706424 | 6 | 0 | 5 |
| NDUFB3 | SAMD3 | 0.703763 | 3 | 0 | 3 |
| NDUFB3 | PDZD11 | 0.701246 | 4 | 0 | 3 |
| NDUFB3 | TLR8-AS1 | 0.700508 | 3 | 0 | 3 |
| NDUFB3 | CAPNS1 | 0.698796 | 3 | 0 | 3 |
For details and further investigation, click here
